Lead Poisoning and Asthma

Myers, Scott A.; Rowell, Bruce; Binns, Helen J.

doi:10.1001/archpedi.156.9.863

Cited by 17 publications

(3 citation statements)

References 26 publications

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“…These findings are also supported by the results of a previous study showing higher prevalence of respiratory symptoms for phlegm, shortness of breath and diagnosed asthma in industrial workers exposed with lead (6). However, there was no increased likelihood of asthma diagnosis or symptoms among young children with lead poisoning (26). The possible reason for this discrepancy is perhaps the long period of lead exposure in studied workers in the present study.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Symptoms and Pulmonary Function Testes in Lead Exposed Workers

Khazdair

Boskabady

Afshari

et al. 2012

Iran Red Crescent Med J

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BackgroundThe exposure to noxious agwents such as lead my cause lung disorders.ObjectivesIn the present study, pulmonary function tests and self-reported respiratory symptoms in lead exposure workers were compared with matched control subjects.Materials and MethodsThe frequency of respiratory symptoms were evaluated in a sample of 108 lead exposure workers and 100 control subjects with similar age using a questionnaire including questions on respiratory symptoms in the past year. Pulmonary function tests (PFT) were also measured in lead exposure workers and in controls.ResultsMost lead exposure workers (63%) reported work-related respiratory symptoms. Chest tightness (26%), cough (17%) and sputum (16%) were the most common symptoms and only 6% of lead exposure workers reported wheezing (P < 0.001 for all case except wheezing). Most PFT values were also significantly reduced among lead exposure workers (P < 0.05 to P < 0.001 except MEF75, MEF50, MEF25, and MMEF. The lead concentration in urine and serum of lead exposure workers were significantly higher than control (P < 0.001 for both cases).ConclusionsThese results showed that c lead exposure workers have higher frequencies of respiratory symptoms higher serum and urine lead concentration but lower PFT values.

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Section: Discussionmentioning

confidence: 99%

Respiratory Symptoms and Pulmonary Function Testes in Lead Exposed Workers

Khazdair

Boskabady

Afshari

et al. 2012

Iran Red Crescent Med J

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“…One study in Poland found blood lead levels to be inversely associated with FVC in children aged 10–15 years old (Little et al 2017). A study using Missouri Medicaid claims data showed no relationship between diagnosed asthma and elevated lead levels (Rabito et al 2013), nor was there a relationship between elevated lead levels and diagnosed asthma among children seen at a Chicago inner-city health center (Myers et al 2002). In contrast, among 930 kindergarten students in Taiwan, lead levels ≥ 5μg/dL were positively associated with asthma (odds ratio=5.5, 95% CI: 1.7 to 17.9) (Wang et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES)

Madrigal

Persky

Pappalardo

et al. 2018

Environment International

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Introduction: Exposure to cadmium, cobalt, lead, and manganese has been associated with decreased pulmonary function in adults. Little is known about the magnitude of these associations among children in the United States. Objectives: We evaluated cross-sectional associations of blood and urinary concentrations of cadmium, cobalt, lead, and manganese with pulmonary function measures [forced expiratory volume in one second (FEV1; milliliters), forced vital capacity (FVC; milliliters), ratio of FEV1 to FVC (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; milliliters/second)] in a sample of 1,234 6–17 year olds, who participated in the 2011–2012 survey cycle of the National Health and Nutrition Examination Survey (NHANES). Methods: Survey-weighted linear regression was used to estimate beta coefficients and 95% confidence intervals (CIs) for the associations between metal exposure tertiles or quartiles and pulmonary function test parameters, with adjustment for relevant covariates. Results: Blood manganese concentration was inversely associated with FVC (β for highest versus lowest quartile=−97.1, 95% CI=−230.6, 36.4; p for trend=0.03). Urinary manganese was inversely associated with FEV1:FVC and FEF 25–75% (p for trend=0.05 and 0.02, respectively). Urinary lead was inversely associated with FEF 25–75% (p for trend=0.01). The associations between blood manganese and both FEV1 and FVC differed by age (p for interaction=0.04 and 0.04, respectively), indicating an inverse trend that was strongest among older youth. Conclusions: Environmental exposure to manganese and lead may adversely impact the pulmonary function of young people in the United States. Our findings highlight a need to prioritize children’s environmental health and evaluate these associations prospectively.

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“…Short-term PM exposure had indicated Statistical modeling complex health data increased risk of morbidity (hospitalizations and emergency visits) with (lag period 2-3 days) and also increased risk of mortality due to respiratory conditions [13,17,[20][21][22][23][24][25]. Ambient Pb exposure and its association with asthma morbidity, among humans, were not extensively studied except in cases, where lead poisoning related asthma attacks among children in which significant effect was justified [26]. A review article showed that the mechanism that connects lead exposure to asthma was through oxidative stress and immune and inflammatory response alternations [27].…”

Section: Introductionmentioning

confidence: 99%

Statistical modeling of complex health outcomes and air pollution data: Application of air quality health indexing for asthma risk assessment

Weerasinghe

2022

ebph

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Background: Statistical models for complex health outcome data analyses with; zero inflation, autocorrelation, confounding, seasonality and delayed exposures, play an important role in accurately assessing air pollution risk, especially in public health warning using national air quality health indices (NAQHI). NAQHI assessment generalizes model estimates across all geographies and seasons and neglects area and season specific variations. The aim is to develop complex statistical models, specific to the complex data structures and to demonstrate effectiveness of the model estimates in public health massage delivery. Methods: A time series model was fitted to asthma hospital admissions and ambient air pollution data from two sites, Halifax, an urban, traffic and industry polluted site and Sydney, a rural waste disposal polluted site, in the province of Nova Scotia, Canada. I fitted zero inflated, auto regressive, Poisson and Negative Binomial models with lagged effects for sparse asthma admissions and air pollution data and compared the model risk estimates with that of the NAQHI. Results: NAQHI used three pollutants, Nitrogen Dioxide, Ozone and particulate matter. I found Carbon monoxide in the urban site and lead in the waste disposal site as prominent pollutants and there were seasonal differences. The findings demonstrated severe under-assessment of asthma relative risk by NAQHI, when prominent pollutants are neglected and also when auto correlation and zero inflation are ignored. Conclusion: This study demonstrated the importance of complex statistical model use and the consequences of lack of such modelling that accounted for data structures in public health risk assessments.

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Lead Poisoning and Asthma

Abstract: There was no increased likelihood of asthma diagnosis or symptoms among young children with lead poisoning. Children with lead poisoning also had delayed medical care. These data may help guide interventions aimed at preventing or reducing the impact of lead poisoning and asthma.

Cited by 17 publications

References 26 publications

Respiratory Symptoms and Pulmonary Function Testes in Lead Exposed Workers

Respiratory Symptoms and Pulmonary Function Testes in Lead Exposed Workers

Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES)

Statistical modeling of complex health outcomes and air pollution data: Application of air quality health indexing for asthma risk assessment

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