Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES)

Madrigal, Jessica M.; Persky, Victoria; Pappalardo, Andrea A.; Argos, Maria

doi:10.1016/j.envint.2018.09.045

Cited by 75 publications

(30 citation statements)

References 45 publications

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“…Pulmonary function indices and asthma in children were linked with Pb [ 27 , 28 ], Mn, Ni, and Cr [ 29 , 30 ], as well as Co and Zn [ 31 ]. Likewise, maternal Pb has been reported in association with elevated blood pressure in 5-year-old children [ 32 ] and prenatal exposure to Cd—with an increased risk of obesity at the age of five [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Karakis

Landau

Gat

et al. 2021

Environ Health Prev Med

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Background The majority of studies linking exposure to metals with certain health outcomes focus on known toxic metals. Alternatively, this study assesses the extent to which exposure to a wider range of metals during gestation is associated with childhood morbidity. Methods We analyzed the concentrations of 25 metals found in urine samples of 111 pregnant women of Arab-Bedouin origin collected prior to birth. In addition, we collected medical records on their offspring for six years following birth, including every interaction with HMOs, local hospitals, and pharmacies. Results The main types of morbidities diagnosed and treated during this period were preterm births, malformations, asthma-like morbidity, cardiovascular and behavioral problems, and obesity. Multivariable analysis showed that offspring born before term were more likely to have been exposed to elevated maternal concentrations of zinc, thallium, aluminum, manganese, and uranium, all with adjusted relative risk above 1.40 for an increase by each quintile. Likewise, children with asthma had been exposed to higher levels of magnesium, strontium, and barium at gestation, while behavioral outcomes were associated with elevated biometals, i.e., sodium, magnesium, calcium, selenium, and zinc, as well as higher levels of lithium, cobalt, nickel, strontium, cadmium, vanadium, arsenic, and molybdenum. A heatmap of adjusted relative risk estimates indicates the considerable implications that exposure to metals may have for preterm birth and developmental outcomes. Conclusions The current study shows that perinatal exposure to metals is adversely associated with pediatric morbidity. Further such analyses on additional samples are warranted.

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Section: Introductionmentioning

confidence: 99%

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Karakis

Landau

Gat

et al. 2021

Environ Health Prev Med

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“…Children are particularly vulnerable, in terms of biological effects, when exposed to metal pollution [13][14][15][16][17], mainly due to oxidative damage following chronic exposure [18,19]. In pediatric age, the body burden of metals has been linked with a number of pathologic conditions including nononcologic diseases (i.e., altered growth and development [20], obesity [21,22], and neurologic [23][24][25], cognitive [26], and respiratory [19,27] disorders) and cancer [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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The impact of waste incinerators is usually examined by measuring environmental pollutants. Biomonitoring has been limited, until now, to few metals and to adults. We explored accumulation of a comprehensive panel of metals in children free-living in an urban area hosting two waste incinerators. Children were divided by georeferentiation in exposed and control groups, and toenail concentrations of 23 metals were thereafter assessed. The percentage of children having toenail metal concentrations above the limit of detection was higher in exposed children than in controls for Al, Ba, Mn, Cu, and V. Exposed children had higher absolute concentrations of Ba, Mn, Cu, and V, as compared with those living in the reference area. The Tobit regression identified living in the exposed area as a significant predictor of Ba, Ni, Cu, Mn, and V concentrations, after adjusting for covariates. The concentrations of Ba, Mn, Ni, and Cu correlated with each other, suggesting a possible common source of emission. Exposure to emissions derived from waste incinerators in an urban setting can lead to body accumulation of specific metals in children. Toenail metal concentration should be considered a noninvasive and adequate biomonitoring tool and an early warning indicator which should integrate the environmental monitoring of pollutants.

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“…Those that have studied pulmonary function or respiratory symptoms with measured metal exposures in children have not been consistent. In a previous cross-sectional study of blood and urinary concentrations of cadmium, cobalt, lead, and manganese in a sample of 1234 children aged 6–17 years from the 2011–2012 NHANES, blood manganese concentration was inversely associated with FEV1 and FVC among older youth [ 10 ]. In that same study, urinary manganese concentration was inversely associated with FEV1:FVC and FEF 25–75%, and urinary lead concentration was inversely associated with FEF 25–75% [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…This linkage suggests that reduced exposure to metals may be effective in reducing morbidity from the disease. Investigations of the effects of metals on pulmonary function in children have examined children in general populations [ 10 , 11 , 12 , 13 ], as well as children living near e-waste facilities [ 3 , 14 ], in areas of high arsenic [ 15 ] or lead exposures [ 4 , 7 , 16 , 17 ], and in an area of ferroalloy industries [ 5 ]. However, results from these studies may have varied, in part, due to different patterns of co-exposure or mixtures of metal exposures.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois

Madrigal

Persky

Jackson

et al. 2021

IJERPH

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Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma.

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Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES)

Cited by 75 publications

References 45 publications

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois

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