Lead induced ultrastructural changes in the testis of rats

Murthy, Ramesh; Saxena, D. K.; Gupta, S.K.; Chandra, Satya V.

doi:10.1016/s0232-1513(11)80054-x

Cited by 20 publications

(5 citation statements)

References 9 publications

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“…However, it is clear that any alteration in the stem cell population would have an irreversible e!ect on germ cell production and adult fertility, and this is probably the most important consequence of lead toxicity. Oral administration of 250 ppm lead acetate to weaning male rats did not cause marked changes at the light microscopy level in testicular tissue, although ultrastructural changes were revealed in the form of vacuolization in Sertoli cell cytoplasm and increase in the number and size of lysosomes (Murthy et al, 1991). Even without impairment of spermatogenesis, the changes in Sertoli cells may lead to changes in spermatogenesis after chronic exposure.…”

Section: Discussionmentioning

confidence: 83%

Lead Intoxication in Gestational and Lactation Periods Alters the Development of Male Reproductive Organs

Corpas

Castillo

Marquina

et al. 2002

Ecotoxicology and Environmental Safety

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Section: Discussionmentioning

confidence: 83%

Lead Intoxication in Gestational and Lactation Periods Alters the Development of Male Reproductive Organs

Corpas

Castillo

Marquina

et al. 2002

Ecotoxicology and Environmental Safety

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“…In addition to the effects on hormone levels, Assennato et al 52 describe a reduction in sperm concentration by a direct, nonhormonal effect, in sperm production or transport. A direct effect of lead on the testes has also been shown in rodents 55,65 .…”

Section: Leadmentioning

confidence: 85%

Occupational exposure and effects on the male reproductive system

2006

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A significant increase in the incidence of male infertility has been described in the international literature, raising questions about its causes. Part of this effect may result from synthetic toxic substances acting on the endocrine system (endocrine disruptors), many of which are routinely used in work processes. We provide a critical review of the specialized literature on work-related chemical substances capable of causing male infertility. Pesticides such as DDT, linuron, and others, heavy metals like mercury, lead, cadmium, and copper, and substances from various industrial uses and residues such as dioxins, polychlorinated biphenyls (PCBs), ethylene dibromide (EDB), phthalates, polyvinyl chloride (PVC), and ethanol are among the main endocrine disruptors that can cause male infertility. Based on the literature, gonadal dysfunction and congenital malformation are the main alterations caused by these substances in the male reproductive system. We conclude that despite the relative lack of studies on this issue, the relevance of such risk calls for further studies as well as measures to prevent workers' exposure to the various substances.

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“…10,11 However, some have failed to demonstrate morphological changes in the gonads of male animals treated with lead. 12,13 Thus, the present study was designed to see the modulating effects of lead and zinc in altering the metabolic and reproductive capabilities of testis and epididymis.…”

Section: Introductionmentioning

confidence: 99%

Influence of lead and zinc on rat male reproduction at ‘biochemical and histopathological levels’

Batra

Nehru

Bansal

2001

J of Applied Toxicology

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Sequential lead accumulation and biochemical and histopathological changes were observed in rat testis and epididymis after oral administration at varied doses of lead (10, 50 and 200 mg kg(-1) body wt.) for 3 months and also following the concomitant administration of lead with zinc (1 mg kg(-1) body wt. +50 mg Pb kg(-1) body wt.). Accumulation of lead in both testis and epididymis increased with dose. The concomitant administration of zinc reduced the lead levels. Similarly, dose-related changes were seen in the activities of the enzymes alkaline phosphatase and Na(+)-K(+)-ATPase, which decreased with increased dose of lead. A significant improvement in the activities of these enzymes was seen in the groups given both lead and zinc. Histologically, discernible changes were noticed only at higher doses (50 and 200 mg kg(-1) body wt.), which included disorganization and disruption of spermatogenesis with accumulation of immature cells in lumen of tubule. At higher doses of lead, complete arrest of spermatogenesis was seen and a significant decrease in germ cell layer population was evident. Even in epididymis, the histoarchitecture was disrupted only at higher doses of lead both in the caput and corpus regions. The changes included damage of basement membrane, disorganization of epithelium and vacuolization of cells. The tubules were found almost empty, indicating arrest of spermatogenesis. However, with concomitant administration of lead and zinc both testis and epididymis presented a near-normal picture, indicating the protective role of zinc. Hence, the data indicate that the protective effect of zinc on lead toxicity was mediated largely by significant competition between lead and zinc or due to reduction of the available binding sites.

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Lead induced ultrastructural changes in the testis of rats

Cited by 20 publications

References 9 publications

Lead Intoxication in Gestational and Lactation Periods Alters the Development of Male Reproductive Organs

Lead Intoxication in Gestational and Lactation Periods Alters the Development of Male Reproductive Organs

Occupational exposure and effects on the male reproductive system

Influence of lead and zinc on rat male reproduction at ‘biochemical and histopathological levels’

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