Lead exposure is a risk for worsening bone mineral density in middle-aged male workers

Akbal, Ayla; Tutkun, Engın; Yilmaz, Hınç

doi:10.3109/13685538.2013.836482

Cited by 18 publications

(22 citation statements)

References 17 publications

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“…decreased T-and Z-score, and Pb exposure have been reported (Akbal, Tutkun, & Yilmaz, 2014;Campbell & Auinger, 2007). In this study, similar observations were also found.…”

Section: Effect Interaction Of Cadmium and Lead Co-exposure On Prevsupporting

confidence: 90%

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Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Yan

et al. 2019

J of Applied Toxicology

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Both cadmium (Cd) and lead (Pb) are associated with bone health, but studies exploring the effects of Cd and Pb co‐exposure on bone health are rare. This study aimed to assess the interactive effects of Cd and Pb co‐exposure on bone health. In total, 799 participants, living in the targeted areas (located in southwestern China) for more than 15 years, aged 40‐75 years, and subsisted on homegrown rice and vegetables were investigated. Cd and Pb levels in urine and blood samples, as well as bone mineral density, T‐ and Z‐score were determined. After being adjusted for covariates, the T‐score was negatively correlated with blood Pb in men (P < .05); for women and non‐smoking women, the T‐score was negatively correlated with urinary Pb (P < .05). Moreover, after being adjusted for covariates, the Z‐score was negatively correlated with urinary Pb in non‐smoking women (P < .05). No positive association of prevalence of osteoporosis with Cd and Pb exposure was found. However, at an additive scale, positive interactions of urinary Cd and Pb on the prevalence of osteoporosis for women and non‐smoking women, and the same interactions to blood Cd and Pb for men were found. There was also a positive interaction of urinary Cd and Pb for women at a multiplicative scale. This study suggests Cd and Pb exposure could exert detrimental effects on bone health, with possible underlying interactions. Nevertheless, more studies are needed to explore the interactive effects of heavy metal co‐exposure.

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“…decreased T-and Z-score, and Pb exposure have been reported (Akbal, Tutkun, & Yilmaz, 2014;Campbell & Auinger, 2007). In this study, similar observations were also found.…”

Section: Effect Interaction Of Cadmium and Lead Co-exposure On Prevsupporting

confidence: 90%

“…Pb is mostly accumulated in the skeleton (Skerfving & Bergdahl, ). Moreover, the relationship between the loss of BMD, decreased T ‐ and Z ‐score, and Pb exposure have been reported (Akbal, Tutkun, & Yilmaz, ; Campbell & Auinger, ). In this study, similar observations were also found.…”

Section: Discussionmentioning

confidence: 98%

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Yan

et al. 2019

J of Applied Toxicology

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“…Başka bir çalışmada ise kan kurşun düzeyi yüksek olan bireylerde kemik mineral yoğunluğu değerlerinin azaldığı saptanmıştır (18). Mesleki kurşun maruziyeti olan orta yaştaki erkek bireylerin osteoporoz risk faktörleri ve kemik mineral yoğunluğu açısından değerlendirildiği başka bir çalışmada kan kurşun düzeyi ile kemik mineral yoğunlukları arasında negatif korelasyon ve kemik yıkım markerleri ile pozitif korelasyon saptanmış ve kronik kurşun maruziyetinin kemik yıkımında önemli bir faktör olabileceği vurgulanmıştır (19).…”

Section: Kurşununclassified

Toxic Effects of Heavy Metals on Bone Tissue

Akbal¹,

Reşorlu²,

Savaş³

2015

Tod

Self Cite

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Ağır metaller doğada yaygın olarak bulunur. Çevresel ve mesleki nedenlerle ağır metallere maruz kalındığı zaman çeşitli sistemlerde toksik etkiler ortaya çıkabilir. Ağır metallere akut ve kronik maruziyette farklı klinik bulgular ortaya çıkar. Birçok ağır metalin primer doku organı kemiktir ve kronik maruziyette kemik dokuda toksik etkiler oluşturur. Bu makalede maruziyetine sık rastlanan ağır metallerin kemik üzerine toksik etkilerinin gözden geçirilmesi amaçlandı. (

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“…9 Bone stores about 99% of the body's calcium in the form of hydroxyapatite and experiences the greatest deposition of Pb for extended period of time. 10,11 Lead has been reported to interfere with bone metabolism through multiple mechanisms that may include interferences with bone formation and bone resorption. 12 Biomarkers of osteoblastic bone formation such as total alkaline phosphatase (ALP) and bone-specific alkaline phosphatase (B-ALP) and biomarkers of osteoclastic bone resorption which include urinary calcium (uCa) and urinary deoxypyridinoline (uDPD), have been reported to provide clinically useful evidence of the normal and pathological processes that reflect bone cell activities and can predict changes in bone-Pb dynamics long before changes in bone density are detected in children.…”

Section: Introductionmentioning

confidence: 99%

Urinary calcium: a promising predictive biomarker for early recognition of environmental lead exposure in children

et al. 2019

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Background: In the continuous search for accessible, reliable and sensitive biomarkers for early detection of environmental lead exposure, authors determined the interaction between blood lead level (BLL), the conventional marker of lead exposure, and the indices of calcium and bone metabolism in children.Methods: This cross-sectional study involved 309 apparently healthy children from eight public primary schools in Ibadan, Nigeria who were classified as Elevated BLL (EBLL) and control based on standard cut-off for childhood BLL. BLL, serum Ca (tCa), phosphate, magnesium (Mg), 25-hydroxy-Vitamin D, alkaline phosphatase (ALP), urinary calcium (uCa) and urinary deoxypyridinoline (uDPD) were determined using AAS, HPLC and ELISA as appropriate. Bone-specific ALP (B-ALP) and ionized calcium (iCa) were calculated using standard formulae. Data analyses involved Student’s t-test, Pearson correlation and multivariate regression analysis. p<0.05 was considered statistically significant.Results: BLL and 25-OH-Vitamin D levels were increased in EBLL (0.4±0.1 µmol/L and 60.1±10.7 mmol/L) compared with control (0.2±0.0 µmol/L and 55.1±14.3 mmol/L) p <0.05. No significant differences existed in the levels of ALP, B-ALP, uCa, uDPD, tCa, iCa, phosphate and Mg in both groups (p>0.05). BLL had significant positive correlation with uCa (r=0.176, p=0.002) (p<0.05) but no significant correlation with uDPD, ALP, B-ALP, tCa, iCa, phosphate, Mg and 25-OH-Vitamin D (p>0.05). BLL could be accounted for by uCa by applying the equation, BLL=0.329+0.324uCa.Conclusions: Urinary calcium could be a promising predictive biomarker for early recognition of significant environmental lead exposure in children.

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Lead exposure is a risk for worsening bone mineral density in middle-aged male workers

Abstract: Lead exposure in male workers is an important factor for deterioration in bone mineral density. We should be screening blood lead levels and history of lead exposure in male osteoporosis.

Cited by 18 publications

References 17 publications

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Toxic Effects of Heavy Metals on Bone Tissue

Urinary calcium: a promising predictive biomarker for early recognition of environmental lead exposure in children

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