Toxic Effects of Heavy Metals on Bone Tissue

Akbal, Ayla; Reşorlu, Hatice; Savaş, Yılmaz

doi:10.4274/tod.31644

Tod

2015

DOI: 10.4274/tod.31644

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Toxic Effects of Heavy Metals on Bone Tissue

Ayla Akbal¹,

Hatice Reşorlu²,

Yılmaz Savaş³

Abstract: Ağır metaller doğada yaygın olarak bulunur. Çevresel ve mesleki nedenlerle ağır metallere maruz kalındığı zaman çeşitli sistemlerde toksik etkiler ortaya çıkabilir. Ağır metallere akut ve kronik maruziyette farklı klinik bulgular ortaya çıkar. Birçok ağır metalin primer doku organı kemiktir ve kronik maruziyette kemik dokuda toksik etkiler oluşturur. Bu makalede maruziyetine sık rastlanan ağır metallerin kemik üzerine toksik etkilerinin gözden geçirilmesi amaçlandı. (

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Cited by 4 publications

(1 citation statement)

References 32 publications

(34 reference statements)

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“…Of concern, heavy metals (e.g., cadmium (Cd) and lead (Pb)) were cumulative bone-toxicants with the contribution to musculoskeletal disease [9]. Compelling toxicological evidence showed that heavy metals were linked to two major pathological changes of OA, including joint damage and inflammation [10,11]. For example, cadmium chloride treatment caused cartilage loss and inflammation in a 3D culture model of human chondrocytes [12].…”

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confidence: 99%

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Chen

Zhao

Liu

et al. 2022

BMC Med

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Background Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk factors. This study aims to evaluate the associations of urinary metals with OA risk and the mediated effect of biological aging. Methods Nine urinary metal concentrations were detected among 12,584 U.S. adults based on the National Health and Nutrition Examination Survey (NHANES), including barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), and uranium (Tu). Multivariable logistic regression and weighted quantile sum (WQS) regression were used to explore the associations of single metal and mixed metals with OA risk, respectively. Furthermore, biological aging was measured from different perspectives, including cell senescence (telomere length) and whole-body aging (phenotypic age and biological age). Mediation analyses were conducted to investigate the mediated effects of aging on the associations of metals with OA risk. Results In the single-exposure model, Cd, Co, and Cs were identified to be positively associated with OA risk, with odds ratios (OR) ranging from 1.48 to 1.64 (all P < 0.05). Mixed-exposure analyses showed consistent associations (OR 1.23, 95%CI 1.10 to 1.37) and highlighted that Cd, Co, and Cs were responsible for the outcomes. Additionally, Cd, Co, Cs, Pb, and Tl were positively associated with biological aging markers, while all biological aging markers had significant associations with OA risk. Further mediation analyses showed that the associations of single metal (mainly Cd and Cs) and mixed metals with OA risk parallelly mediated by the above biological aging markers, with the proportion of mediation ranging from 16.89 to 69.39% (all P < 0.05). Moreover, such associations were also serially mediated through telomere length-biological age path and telomere length-phenotypic age path (the proportion of mediation: 4.17–11.67%), indicating that metals accelerated cell senescence to lead to whole-body aging and finally aggravated OA progress. Conclusions These findings suggested that exposure to metals increased OA risk, which was possibly and partly mediated by biological aging.

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mentioning

confidence: 99%

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Chen

Zhao

Liu

et al. 2022

BMC Med

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Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999–2018

Chen

Sun²,

Peng

et al. 2022

Chemosphere

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Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells

Ulutas

Coşan

Mutlu

2020

Journal of Basic and Clinical Physiology and Pharmacology

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ObjectivesExposure to cadmium (Cd), which causes environmental and industrial pollution, causes toxicity in many tissues and organs, especially bone, lung and kidney. Hormones, growth factors and other stimuli act on bone tissue through osteoblasts. In this study, it was aimed to determine the effects of Cd on hFOB1.19 osteoblast cells and the protective and healing potentials of estrogen, androgen and vitamin D against the inhibitory effect of Cd on the proliferation.MethodshFOB1.19 cells were cultivated in our laboratory using Dulbecco’s Modified Eagle’s Medium-F12, HEPES medium, containing 10% fetal bovine serum, 1% penicillin/streptomycin in 34.5 °C 5%CO2 incubator. To determine its protective potentials for the toxicity of CdCl2, it was previously applied 1,25(OH) 2D vitamin, 17β-estradiol, and 5α-androstane for 72 h to cells. To determine their curative potential, osteoblast cells, which were previously exposed to CdCl2 for 72 h, were administered 1,25(OH) 2D vitamin, 17β-estradiol, and 5α-androstane. Following these applications were determined proliferation by XTT analysis and, the amounts of androgen receptor, estrogen receptor, vitamin D receptor, alkaline phosphatase, osteocalcin and osteoprotegerin by ELISA analysis.ResultsVitamin D has been both preventive and curative effective to increase cell proliferation, which Cd reduces. Interestingly, estrogen had a preventive effect and androgen had a curative effect.ConclusionsIn addition to showing the negative effects of cadmium on the proliferation of osteoblast cells, this study provides an overview of the effects of hormone and vitamin D applications before and after Cd, and these results may serve as a guide for future studies.

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Toxic Effects of Heavy Metals on Bone Tissue

Cited by 4 publications

References 32 publications

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999–2018

Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells

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