Lead and cadmium exposure, higher thyroid antibodies and thyroid dysfunction in Chinese women

Nie, Xiaomin; Chen, Yi; Chen, Chi; Han, Bing; Li, Qin; Zhu, Chunfang; Xia, Fangzhen; Zhai, Hualing; Wang, Ningjian; Lu, Yingli

doi:10.1016/j.envpol.2017.06.052

Cited by 73 publications

(47 citation statements)

References 31 publications

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“…Novel studies in humans examined the possible role of Cd in autoimmune processes in the thyroid gland. The study based on the 2014 SPECT-China study (including 5628 Chinese adults) showed the relation of blood Cd levels and sera antibodies to thyroid proteins and thyroid dysfunction reflected by total T3, total T4 and TSH levels [ 10 ]. Blood Cd levels positively correlated to higher TSH and hypothyroid status in women and higher antibodies levels in women.…”

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

“…Changes in circulating free T3 and T4 may be due to alterations in the function of Tg, the thyroid hormone binding globulin. Free, unbound, hormone is the active form of the hormone and there is evidence that suggests increases in Tg expression leads to reduced free levels of T3 and T4 [ 10 ]. The positive correlation between Cd and Tg levels was most pronounced in females.…”

Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

“…Moreover, in a study in proestrous rats, it was shown that Cd accumulates in various brain regions responsible for the control of pituitary hormones release [ 83 ]. As previously mentioned, Cd also induces thyroid autoimmunity that can be conjectured to be associated with its ability to activate estrogen receptors [ 10 ], which could be one more Cd-mediated extra-thyroidal toxic mechanism. The study using a rat model of preeclampsia, autoimmunity-related disease supported this hypothesis [ 84 ].…”

Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

“…In recent decades, the prevalence of autoimmune thyroid diseases and thyroid cancers has increased. The elevation of specific antibodies, used as standard laboratory biomarkers for the autoimmune thyroid disease diagnosis, is of great concern nowadays [ 10 ]. A recent study on Danish twins demonstrated that apart from genetic factors, another critical factor responsible for the presence of these biomarkers are environmental factors, which account for 20–30% [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

159

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Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

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Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

159

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“…Excess intake of iodine through seafood consumption is a suspected risk factor for thyroid cancer [355]. Also, some seaweeds are contaminated with arsenic, mercury, cadmium and other heavy metals that have positive association with thyroid hormones in adults [356][357][358][359][360].…”

Section: Thyroid Functionmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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