Leaching of nickel, chromium, and beryllium ions from base metal alloy in an artificial oral environment

Tai, Y. F.; Long, Ralph De; Goodkind, Richard J.; Douglas, William H.

doi:10.1016/0022-3913(92)90388-q

Cited by 49 publications

(27 citation statements)

References 14 publications

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“…However, Be ions, which were released at levels from four to six times those of the bulk alloy compositions, are regarded as having high toxicities (Covington et al, 1985). The elevated release of Be ions found in this study agreed well with previous reports of elevated Be ion release from other Be-containing alloys in other physiological solutions (Geis-Gerstorfer and Weber, 1987;Covington et al, 1985;Tai et al, 1992).…”

Section: Mnsupporting

confidence: 93%

“…Cr released from the alloys was very low, especially compared with the release of Mo and Mn ions. Similarly low Cr release data have been reported for Ni-Cr alloys in artificial saliva, lactic acid, and saline solutions (Geis-Gerstorfer and Weber, 1987;Tai et al, 1992). The reason for the increased release of Mo and Mn ions from the alloys, compared with Cr, is not known at this time.…”

Section: Mnmentioning

confidence: 71%

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Cellular Response to Metallic Ions Released from Nickel-Chromium Dental Alloys

1995

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Concerns exist over the potential release of elevated levels of metal ions such as Ni and Be from Ni-Cr dental casting alloys, due to their susceptibility to accelerated corrosion. In this investigation, we evaluated the release of metal ions from four commercial Ni-Cr alloys, representing a range of compositions, in three-day cell culture tests. Metal ion release, as measured by atomic absorption spectroscopy, was correlated to changes in cellular morphology, viability, and proliferation. The results showed that the test alloys and their corrosion products did not affect cellular morphology or viabilities, but did decrease cellular proliferation. The types and amounts of metal ions released, which corresponded to the alloys' reported surface and corrosion properties, also correlated to observed decreases in cellular proliferation after 72 h. Neptune, which caused the smallest decrease in cellular proliferation as compared with control cells, released the lowest amount of corrosion products, due to its corrosion-resistant, high-Cr-Mo-containing, homogeneous surface oxide. The other test alloys, which were susceptible to accelerated corrosion processes, released higher levels of metal ions that correlated to larger decreases in thymidine incorporation. Metal ion levels increased with test time for all alloys but were not proportional to bulk alloy compositions. Ni ions were released at slightly higher than bulk alloy compositions, while Be was released at from four to six times that of bulk alloy compositions. The elevated release of Be ions was associated with reduced cellular proliferation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Mnsupporting

confidence: 93%

Section: Mnmentioning

confidence: 71%

Cellular Response to Metallic Ions Released from Nickel-Chromium Dental Alloys

1995

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“…Noble and high-noble alloys were, in general, much more resistant to corrosion and released a very low amount of zinc. In addition, Tai et al [26] found that nickel and beryllium were released in vitro both by dissolution and occlusal wear from nickelechromium alloy after a simulated oneyear period of mastication.…”

Section: Ion Releasementioning

confidence: 98%

“…Ion release from dental alloys has been evaluated mainly by in vitro studies, in which the alloy is subjected to different settings: galvanism [19], electrolyte bath [14], oral proteins [24], different pH levels [18], brushing with toothpaste [25], artificial oral environment capable of reproducing three-dimensional forcemovement cycles of human mastication [26].…”

Section: Ion Releasementioning

confidence: 99%

Biocompatibility of dental alloys used in dental fixed prosthodontics

Elshahawy

Watanabe

2014

Tanta Dental Journal

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Many different types of alloys are now available in the market to be used for dental restorations and fixed prostheses. The common criterion for all these fixed prosthodontic materials is the permanent existence of them in the oral cavity for prolonged time without the ability to be removed by the patient. Therefore, knowledge about the biocompatibility of dental alloys is of great importance. This article presents a literature review on the biocompatibility of dental alloys. A PubMed database search was conducted for studies pertaining to the biocompatibility of dental alloys. The search was limited to peer-reviewed articles published in English between 1985 and 2013. Available data revealed that substances are released from alloys into the surrounding tissues; mainly nickel, zinc, and copper. Some alloys such as nickelechromium alloy have shown to be cytotoxic in vitro. Also, elements released from gold alloy showed in vitro cytotoxic effect. Therefore, clinicians should give up assuming that gold alloy is completely inert and biocompatible with oral tissues. The clinical relevance of these findings remains unclear. Further in vitro studies, as well as controlled clinical trials, are needed due to possible exceptions.

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“…The artificial saliva used in this study was a modified Meyer's solution whose chloride content and corrosive activity have been demonstrated to be similar to natural saliva. 27 Each arch wire was placed in a section of clear tygon surgical grade tubing. Each end of the tube was sealed by an ultra high-molecular-weight polyethylene stopper.…”

Section: Mechanical Testsmentioning

confidence: 99%