Le myoépithéliome du sein. Difficultés diagnostiques et thérapeutiques. À propos d’un cas

Kdous, Moez; Hachicha, Rim; Gamoudi, A.; Rahal, Khaled

doi:10.1016/j.gyobfe.2003.11.004

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…This tumor is rarely reported before [6][7][8][9][10][11][12][13][14][15], this paper is a report of an 8-year-old girl who presented iso sexual precocious puberty and works which are done to find the underlying cause ended up in Juvenile granulosa and theca cell tumor of the ovary. 3 IU/lit), luteinizing hormone was 1.9 (0.1 -5 IU/lit), stradiol was 120.9 (6 -27 pg/ml), serum cortisol of 8 AM was 15 μg/dl (5 -23 μg/dl).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Cause of Precocious Puberty in an 8-Year-Old Girl Ended up in Juvenile Granulosa and Theca Cell Tumor of the Ovary

Ordooei¹,

Karimi-Zarchi²,

Malekzadeh³

et al. 2013

JCT

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Isosexual precocious puberty in girls has several etiologies. Juvenile granulose cell tumor is one of the rarest causes that only stands for 1.5% of ovarian cancers. This tumor mostly encounters in first 2 decades of life. This paper is a report of an 8-year-old girl with precocious puberty that within five months developed breast enlargement followed by menarche. Works which are done to find the underlying cause of precocious puberty revealed juvenile granulosa cell tumor in her left ovary. She then under went laparoscopic surgery and 3 courses of chemotherapy. She did not experience any vaginal bleeding after that and the serum level of estradiol lay among its normal ranges, but after that the tumor relapsed and presented as abdominal pain and a huge mass which under went resection of all afflicted tissues. After 2 courses of chemotherapy, her status deteriorated and unfortunately she died after 6 months from the time of diagnosis. Treatment for this disease is consists of resection surgery and chemotherapy. If this tumor is diagnosed in its early stages, it will be curable, but in its advanced stages, up to 80% of patients die from recurrent tumors. The reported patient was diagnosed at stage IIIC that had poor prognosis.

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