Carcinome myoépithélial malin mammaire : difficultés diagnostiques et thérapeutiques

Poret, H.; Cormier, Béatrice; Marret, H.; Body, G.; Ouldamer, Lobna

doi:10.1016/j.gyobfe.2012.07.032

Cited by 3 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Myoepithelial carcinoma has an aggressive course, with locally invasive and widespread metastatic potential to several organs, commonly the liver and lungs, and the tendency to recur, even with clear resection margins. The treatment of choice is surgical, namely wide tumor excision or mastectomy with regional lymph node excision ( 5 , 10 , 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Myoepithelial carcinoma is generally a solitary lesion, characterized by an infiltrating proliferation of plump atypical spindle cells with easily identifiable mitotic figures and without an epithelial component, dispersed in a collagenous stroma ( 1 , 8 – 10 ). Myoepithelial cells are usually prominent in ducts and ductules in the periphery of the lesion.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant myoepithelioma of the breast: A case report and review of the literature

Papazian

Kalantzis

Galanopoulos

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Malignant myoepithelioma of the breast is an extremely rare tumor composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation. Only a limited number of case reports have been descibed to date; therefore the biological behavior and treatment outcomes of this rare tumor have not been clearly determined. Herein, we present a case of a 74-year-old woman who was admitted with inflammatory-like cancer of the breast, presenting with invasion of the chest wall and axillary lymph node metastasis at the time of diagnosis. The histological examination revealed a tumor composed of epithelioid and spindle cells with moderate to marked nuclear atypia, with foci of hemorrhage and necrosis. The tumor cells were immunoreactive for vimentin, p63, p53, CD10, cytokeratin (CK)8/18, CKAE1-3 and S-100. Finally, a diagnosis of myoepithelial carcinoma of the breast was established. Neoadjuvant chemotherapy was first administered and proved to be ineffective. Due to locoregional progression that was associated with the development of an abscess and subsequent excessive bleeding, a palliative mastectomy was performed. Postoperatively, one more cycle of systemic chemotherapy was administered. However, the patient experienced an early relapse to the chest wall and succumbed to septic shock due to persistent local infection. The aggressiveness and chemoresistance of the tumor in this case was consistent with the existing bibliography.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%