A case of adenomyoepithelioma with myoepithelial carcinoma of the breast

Ito, Ryota; Ota, Daisuke; Ando, Sumiyo; Mori, Masaya; Fukuuchi, Atsushi

doi:10.1002/ccr3.2100

Cited by 11 publications

(12 citation statements)

References 16 publications

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“…There are no clear treatment guidelines for AME. Lumpectomy with a safety margin or quadrantectomy is often performed, and total mastectomy is sometimes performed for large or suspected malignant tumors[ 5 , 6 , 8 , 11 - 13 , 16 ]. Incomplete resection or malignant transformation is a risk factor for local recurrence, but it is important to note that local recurrence can occur even with clearly negative margins in a benign lesion, as observed in our patient.…”

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report

Oda

Nakagawa

Mori

et al. 2021

WJCC

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BACKGROUND Adenomyoepithelioma (AME) of the breast is a rare type of benign breast tumor. Many AMEs show benign behavior, but reports of the malignant type are rare. We present the case of a patient with AME with repeated local recurrences and further malignant transformation. CASE SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast. A core needle biopsy was performed. The pathological diagnosis was AME. Lumpectomy with a safety margin was performed without axillary lymph node dissection (ALND). Two years later, local recurrence developed, and the patient again underwent lumpectomy with a safety margin. The pathology showed malignant AME, and the margin was negative. Eight months later, local recurrence developed again in the same location, and a total mastectomy was performed without ALND. The pathological diagnosis was malignant AME. The patient was disease-free for three years posttreatment. CONCLUSION The treatment of AME requires caution, as it may exhibit repeated recurrences after local excision as well as malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report

Oda

Nakagawa

Mori

et al. 2021

WJCC

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“…There are no clear treatment guidelines for AME. Partial mastectomy is often performed, but total mastectomy is sometimes performed for large or suspected malignant tumors [6]. Axillary lymph node metastases are rare, and only a few cases of axillary dissection have been reported [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…There may be recurrences even after complete resection with partial mastectomy, as in the present case, and they should be carefully monitored. Ito et al concluded that, based on previous reports, total mastectomy is often performed for tumors larger than 3 cm [6]. It will become clearer as more cases are reported which patients should undergo total mastectomy, and whether reconstruction is possible after resection.…”

Section: Discussionmentioning

confidence: 99%

“…Adenomyoepithelioma (AME) is as very rare type of benign tumor of the breast. Many AMEs have demonstrated benign behavior and are often cured with excision with negative margins, but some have exhibited malignant transformation of the myoepithelium, glandular epithelium, or both [1][2][3][4][5][6]. In this report, the case of a patient with repeated local recurrences and malignant transformation is presented.…”

Section: Introductionmentioning

confidence: 95%

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Adenomyoepithelioma with malignant transformation and repeated local recurrence: A case report

Oda¹,

Nakagawa²,

Sugimoto³

et al. 2020

Preprint

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Background Adenomyoepithelioma (AME) is a rare type of benign breast tumor. Many AMEs have demonstrated benign behavior, but very few cases of malignant AME have been reported. Case presentation A 53-year-old woman visited our hospital with a 16-mm, palpable mass in the right breast. Core needle biopsy was performed. The pathological diagnosis was AME. Partial mastectomy was performed. Two years later, local recurrence developed, and the patient again underwent partial mastectomy. The pathology showed malignant AME, and the margin was negative. Eight months later, local recurrence developed again in the same location, and total mastectomy was performed. The pathological diagnosis was malignant AME. The patient has remained recurrence-free without adjuvant therapy.Conclusions A very rare case of AME with repeated local recurrences and malignant transformation was reported.

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“…AMEs are usually difficult to diagnose and need an experimented pathologist and the using of immunohistochemistry. Sometimes they can be misdiagnosed when the core needle biopsy doesn´t encompass both the epithelial and myoepithelial components [ 1 ]. The management usually consists of a lumpectomy or wide excision if the size is under 3 cm, whereas a mastectomy with axillary lymph node resection is usually performed when the size is bigger [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Benign adenomyoepithelioma of the breast: a case report

Belhaddad¹,

Souabni²,

Nejmaddine³

et al. 2022

Pan Afr Med J

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The diagnosis of adenomyoepitheliomas is difficult and relies on the presence of a double component of epithelial and myoepithelial cells belonging to the breast lobules and ducts. The clinical and imaging characteristics are not specific; thus, the diagnosis is histological. In this article, we present a case of a young female who presented with a 2 cm lump in the breast without other clinical symptoms, which revealed a benign adenomyoepithelioma (AME). We performed a large excisional lumpectomy, and the patient recovered well with no complication or recurrence within two years follow-up. When it comes to adenomyoepitheliomas, the published literature is mainly composed of case reports, so much so that there are no evidence-based guidelines. Our case shows that an excisional lumpectomy is often enough when facing a small size tumor with no signs of malignancy, which contributes to the limited data on the subject.

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A case of adenomyoepithelioma with myoepithelial carcinoma of the breast

Cited by 11 publications

References 16 publications

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report

Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report

Adenomyoepithelioma with malignant transformation and repeated local recurrence: A case report

Benign adenomyoepithelioma of the breast: a case report

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