Le facteur de transcription ChREBP

Benhamed, Fadila; Poupeau, Audrey; Postic, Catherine

doi:10.1051/medsci/2013298016

Cited by 4 publications

(2 citation statements)

References 34 publications

(47 reference statements)

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“…We can speculate the effects of diet composition on metabolic responses since nutrients can act systemically as cellular signals [26]. The higher amount of sucrose in the high refined carbohydrate diet compared to that in the control diet could promote an increase in the activation of lipogenic enzymes due to the activation of ChREBP as well as an increased inflammatory response and insulin resistance [11, 26]. In addition, De Lima et al (2008) pointed out that high amounts of sucrose in the diet lead to a higher glycemic index, resulting in the elevation of blood glucose and postprandial insulin concentration and favoring fat storage [41].…”

Section: Discussionmentioning

confidence: 99%

“…These macronutrients are responsible for the systemic, chronic low-grade inflammation associated with obesity [10]. Carbohydrates trigger lipogenic enzymes due to the activation of the carbohydrate-responsive element-binding protein (ChREBP), thus favoring the development of obesity [11]. In obesity, the adipocytes release free fatty acids (FFAs) that activate the signaling pathways of inflammation.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice

Soares

Campos

Peña

et al. 2016

Oxidative Medicine and Cellular Longevity

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Obesity is a multifactorial disease with genetic, social, and environmental influences. This study aims at analyzing the effects of the combination of a refined carbohydrate diet and exposure to hyperoxia on the pulmonary oxidative and inflammatory response in mice. Twenty-four mice were divided into four groups: control group (CG), hyperoxia group (HG), refined carbohydrate diet group (RCDG), and refined carbohydrate diet + hyperoxia group (RCDHG). The experimental diet was composed of 10% sugar, 45% standard diet, and 45% sweet condensed milk. For 24 hours, the HG and RCDHG were exposed to hyperoxia and the CG and RCDG to ambient air. After the exposures were completed, the animals were euthanized, and blood, bronchoalveolar lavage fluid, and lungs were collected for analyses. The HG showed higher levels of interferon-γ in adipose tissue as compared to other groups and higher levels of interleukin-10 and tumor necrosis factor-α compared to the CG and RCDHG. SOD and CAT activities in the pulmonary parenchyma decreased in the RCDHG as compared to the CG. There was an increase of lipid peroxidation in the HG, RCDG, and RCDHG as compared to the CG. A refined carbohydrate diet combined with hyperoxia promoted inflammation and redox imbalance in adult mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice

Soares

Campos

Peña

et al. 2016

Oxidative Medicine and Cellular Longevity

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Les FAHFAs, une nouvelle classe de lipides endogènes bioactifs

Benlebna

Balas²,

Casas

et al. 2018

Cahiers de Nutrition et de Diététique

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Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats

Liu

Lian

et al. 2017

Sci Rep

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Chronic treatment with second-generation antipsychotic drugs (SGAs) has been associated with an increased risk of metabolic syndrome. To evaluate the longitudinal changes in glucose-lipid homeostasis after SGA use, we studied the time-dependent effects of olanzapine (OLZ) (3 mg/kg, b.i.d.) or clozapine (CLZ) (20 mg/kg, b.i.d.) treatment on metabolic profiles for 9 weeks in rats. Although only OLZ significantly increased body weight in rats, both OLZ and CLZ elevated blood lipid levels. Chronic OLZ treatment induced significant weight gain leading to a higher fasting insulin level and impaired glucose tolerance, whereas CLZ lowered fasting insulin levels and impaired glucose tolerance independent of weight gain. Treatment with both drugs deranged AKT/GSK phosphorylation and up-regulated muscarinic M3 receptors in the rats’ livers. Consistent with an elevation in lipid levels, both OLZ and CLZ significantly increased the protein levels of nuclear sterol regulatory element-binding proteins (SREBPs) in the liver, which was associated with improvement in hepatic histamine H1R. However, enhanced carbohydrate response element binding protein (ChREBP) signalling was observed in only CLZ-treated rats. These results suggest that SGA-induced glucose-lipid metabolic disturbances could be independent of weight gain, possibly through activation of SREBP/ChREBP in the liver.

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Le facteur de transcription ChREBP

Cited by 4 publications

References 34 publications

The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice

The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice

Les FAHFAs, une nouvelle classe de lipides endogènes bioactifs

Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats

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