Le « biofilm viral » : un nouveau mode de dissémination des virus ?

Thoulouze, María-Isabel; Alcover, Andrés

doi:10.1051/medsci/2010266-7571

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…Lymphocytes infected with HTLV-1 have also been shown to store viral particles in an unconventional way, as clusters located on the surface of T CD4 + lymphocytes ( Thoulouze and Alcover, 2010 ). These clusters correspond to viral assembly sites and are enriched in carbohydrates and extracellular matrix components including collagen and Agrin, a heparan sulfate proteoglycan ( Pais-Correia et al, 2010 ; Thoulouze and Alcover, 2010 ). High-level expression of the host cell actin-bundling protein fascin is induced by HTLV-1 Tax in infected T-cells ( Kress et al, 2011 ).…”

Section: Modes Of Cell-to-cell Spreadmentioning

confidence: 99%

“…Fascin contributes to cell-to-cell HTLV transmission, and has been suggested to be involved in transport and fitting gag into viral biofilms ( Gross et al, 2016 ). Remarkably, the clusters are transferred from infected cells to recipient cells during cell contact, and it was estimated that 80% of the infectious capacity of HTLV-1 comes from these structures ( Pais-Correia et al, 2010 ; Thoulouze and Alcover, 2010 ). The mechanism shares several similarities with bacterial biofilms, and both improved spread and escape from the immune response might be advantages of this mechanism of viral cell-to-cell spread.…”

Section: Modes Of Cell-to-cell Spreadmentioning

confidence: 99%

“…Antibody resistant cell-to-cell spread of enveloped VACV particles occurs in an actin-dependent or -independent manner likely mediated by protein A33 ( Krupovic et al, 2010 ; Law et al, 2002 ). The formation of viral biofilms by HTLV-1 may also provide a way of physically protecting particles from circulating antibodies which recognize the Env protein ( Pais-Correia et al, 2010 ; Thoulouze and Alcover, 2010 ). For HIV-1, several reports show conflicting results on the role of neutralizing antibodies in inhibiting cell-to-cell transmission, with some studies showing decreased neutralization during cell-to-cell spread and others showing no inhibition of neutralizing antibodies on direct virus transfer.…”

Section: Advantages Of Direct Cell-to-cell Spreadmentioning

confidence: 99%

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Viral cell-to-cell spread: Conventional and non-conventional ways

Cifuentes-Muñoz

Najjar

Dutch

2020

Virus Assembly and Exit Pathways

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A critical step in the life cycle of a virus is spread to a new target cell, which generally involves the release of new viral particles from the infected cell which can then initiate infection in the next target cell. While cell-free viral particles released into the extracellular environment are necessary for long distance spread, there are disadvantages to this mechanism. These include the presence of immune system components, the low success rate of infection by single particles, and the relative fragility of viral particles in the environment. Several mechanisms of direct cell-to-cell spread have been reported for animal viruses which would avoid the issues associated with cell-free particles. A number of viruses can utilize several different mechanisms of direct cell-to-cell spread, but our understanding of the differential usage by these pathogens is modest. Although the mechanisms of cell-to-cell spread differ among viruses, there is a common exploitation of key pathways and components of the cellular cytoskeleton. Remarkably, some of the viral mechanisms of cell-to-cell spread are surprisingly similar to those used by bacteria. Here we summarize the current knowledge of the conventional and non-conventional mechanisms of viral spread, the common methods used to detect viral spread, and the impact that these mechanisms can have on viral pathogenesis.

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Section: Modes Of Cell-to-cell Spreadmentioning

confidence: 99%

Section: Modes Of Cell-to-cell Spreadmentioning

confidence: 99%

Section: Advantages Of Direct Cell-to-cell Spreadmentioning

confidence: 99%

See 1 more Smart Citation

Viral cell-to-cell spread: Conventional and non-conventional ways

Cifuentes-Muñoz

Najjar

Dutch

2020

Virus Assembly and Exit Pathways

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show abstract

“…La synapse immunologique et la polarisation du MTOC sont les conséquences de l'engagement des récepteurs impliqués dans l'activation immunitaire comme le TcR, CD28, LFA-1 (leukocyte function-associated antigen) et CD50 ou ICAM-3 (intercellular cell-adhesion molecule 3) [57]. Au contraire, dans les cellules infectées par HTLV-1, ces évènements sont indépendants de l'activation du TcR, de la voie NF-B [20,30] ou de l'engagement de CD28, CD2 ou CD50 [31].…”

Section: Une Transmission Polarisée Au Niveau Du Point De Contact Celunclassified

“…fait dans la synapse immunologique [57], le MTOC se polarise au point de contact lors de la formation de la synapse virologique [27]. À la différence de la synapse immunologique, cette polarisation a lieu dans la cellule infectée et non dans la cellule cible.…”

Section: Une Transmission Polarisée Au Niveau Du Point De Contact Celunclassified