Role of Virus on Oral Biofilm: Inducer or Eradicator?

Ray, Rina Rani

doi:10.1007/s12010-023-04639-y

Cited by 2 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Soft tissues, such as the gums and cheeks, facilitate colonization by pathogens. The oral biome is a dynamic environment with not only host–pathogen interactions, but also between different pathogens [ 25 ]. The first contact and infection of many pathogens occurs during childhood.…”

Section: Discussionmentioning

confidence: 99%

Molecular Detection of HPV, EBV, HSV-1, HCMV, and H. pylori Pathogens: An Evaluation among Polish Children with Molar Incisor Hypomineralization (MIH)

Tynior,

Świętek,

Hudy

et al. 2024

Pathogens

View full text Add to dashboard Cite

Molar incisor hypomineralization (MIH) is a congenital disorder of the enamel tissue, characterized by a quantitative deficiency. In childhood, infections such as EBV, HSV-1, HCMV, or H. pylori may occur and cause various diseases. This study aimed to investigate the prevalence of HPV, EBV, HSV-1, HCMV, and H. pylori infections in two groups of children: children with molar incisor hypomineralization (MIH) and a control group, using molecular methods. The study group included 47 children aged between 6–13 years who had been diagnosed with MIH. The control group consisted of 42 children. The study found that, in the MIH group, the prevalence of HPV-16 was 6.38%, HPV-18 was 4.26%, EBV was 31.91%, HSV-1 was 4.26%, HCMV was 4.26%, and H. pylori was 12.77%. There were no significant differences in the prevalence of any of tested pathogens between the study and the control group (p > 0.05). However, the study found a higher prevalence of EBV infection in children who had smallpox/pneumonia by the age of 3 years. Ten children were found to have at least two pathogens present. Moreover, both groups had a high prevalence and activity of EBV. These findings provide new insights into the carriage of pathogens among children with MIH, providing new information for parents, scientists, and healthcare professionals.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular Detection of HPV, EBV, HSV-1, HCMV, and H. pylori Pathogens: An Evaluation among Polish Children with Molar Incisor Hypomineralization (MIH)

Tynior,

Świętek,

Hudy

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

“…The formation of such exostructures is optional and present only in certain species and strains of bacteria. The role of capsules and the biofilm matrix in the interactions of bacteria with their viruses, bacteriophages, have been extensively studied and recently reviewed elsewhere [6][7][8]. In Gram-negative bacteria, the actual outer surface of cells consists of an outer membrane (OM), which in most cases is covered by an additional polysaccharide structure termed an O antigen or O polysaccharide (OPS).…”

Section: Ops Can Serve As Physical Barriers To Phage Adsorption 1exop...mentioning

confidence: 99%

Bacterial Virus Forcing of Bacterial O-Antigen Shields: Lessons from Coliphages

Letarov

2023

IJMS

View full text Add to dashboard Cite

In most Gram-negative bacteria, outer membrane (OM) lipopolysaccharide (LPS) molecules carry long polysaccharide chains known as the O antigens or O polysaccharides (OPS). The OPS structure varies highly from strain to strain, with more than 188 O serotypes described in E. coli. Although many bacteriophages recognize OPS as their primary receptors, these molecules can also screen OM proteins and other OM surface receptors from direct interaction with phage receptor-binding proteins (RBP). In this review, I analyze the body of evidence indicating that most of the E. coli OPS types robustly shield cells completely, preventing phage access to the OM surface. This shield not only blocks virulent phages but also restricts the acquisition of prophages. The available data suggest that OPS-mediated OM shielding is not merely one of many mechanisms of bacterial resistance to phages. Rather, it is an omnipresent factor significantly affecting the ecology, phage–host co-evolution and other related processes in E. coli and probably in many other species of Gram-negative bacteria. The phages, in turn, evolved multiple mechanisms to break through the OPS layer. These mechanisms rely on the phage RBPs recognizing the OPS or on using alternative receptors exposed above the OPS layer. The data allow one to forward the interpretation that, regardless of the type of receptors used, primary receptor recognition is always followed by the generation of a mechanical force driving the phage tail through the OPS layer. This force may be created by molecular motors of enzymatically active tail spikes or by virion structural re-arrangements at the moment of infection.

show abstract

Role of Virus on Oral Biofilm: Inducer or Eradicator?

Cited by 2 publications

References 71 publications

Molecular Detection of HPV, EBV, HSV-1, HCMV, and H. pylori Pathogens: An Evaluation among Polish Children with Molar Incisor Hypomineralization (MIH)

Molecular Detection of HPV, EBV, HSV-1, HCMV, and H. pylori Pathogens: An Evaluation among Polish Children with Molar Incisor Hypomineralization (MIH)

Bacterial Virus Forcing of Bacterial O-Antigen Shields: Lessons from Coliphages

Contact Info

Product

Resources

About