LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies

Revilla, Giovanna; Cedó, Lídia; Tondo, Mireia; Moral, Antonio; Peŕez, José Ignacio Arias; Corcoy, Rosa; Lerma, Enrique; Fusté, Victòria; Reddy, S; Blanco‐Vaca, Francisco; Mato, Eugènia; Escolà‐Gil, Joan Carles

doi:10.1016/j.semcancer.2020.11.012

Cited by 36 publications

(30 citation statements)

References 329 publications

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“…Cholesterol plays a critical role in cancer progression by enhancing cell proliferation, migration, and invasion [ 10 ]. High-density lipoprotein (HDL) is the predominant lipoprotein cholesterol that transports cholesterol into major steroidogenic organs [ 11 , 12 ]. The anticancer action of HDL is attributed to its pleiotropic properties, including its anti-oxidative action, modulation of cytokine production, inhibition of apoptosis, as well as promotion of cell growth and migration [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

et al. 2021

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Background Intraductal papillary mucinous neoplasms (IPMNs) can potentially undergo malignant transformation. Studies have shown that high-density lipoprotein cholesterol (HDL-c) was associated with the risk of cancer. In this study, the association between HDL-c and the incidence of malignancy in IPMNs was investigated. Materials and methods 226 patients with histologically proven IPMNs who underwent surgery were included in the present study. Patients were assigned to a training group (n = 151) and validation group (n = 75). Patients’ demographic information, clinical data, and histopathological evaluation findings were obtained from medical records. Malignant IPMNs were defined as lesions that showed high grade dysplasia and invasive carcinoma. Logistic regression analyses were used to show the association between HDL-c and malignant IPMNs. Receiver operating characteristic (ROC) curves were generated to analyze predictive performance. Results The prevalence of low HDL-c levels was higher in patients with malignant IPMNs than in those with non-malignant IPMNs (P < 0.01) in both the training group and validation group. The prevalence of malignant IPMNs decreased with an increase in HDL-c levels both in patients with all types of IPMNs, as well as in those with branch-duct IPMNs (BD-IPMNs).Logistic analysis showed that low HDL-c levels were associated with malignant IPMNs (odds ratio (OR) = 20.56, 95 % confidence interval (CI): 2.58–163.64, P < 0.01) in all types of IPMNs and BD-IPMNs (OR = 17.6, 95 %CI: 1.16–268.46, P = 0.02 ).The predictive performance of mural nodules plus low HDL-c levels was higher than that of mural nodules alone or mural nodules plus cyst size for the identification of malignant BD-IPMNs. Conclusions HDL-c levels may serve a potential biomarker for identifying malignant IPMNs and improve the predictive ability of malignancy in BD-IPMNs.

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Section: Introductionmentioning

confidence: 99%

Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

et al. 2021

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“…An inverse relationship between serum total cholesterol levels and cancer risk has been reported [24][25][26]. Moreover, the associations between HDL-c and cancer risk, disease free survival (DFS) or overall survival (OS) have been reported in many malignancies [11,[16][17][18][19][20][21][22]27]. Low HDL-C levels were associated with high TNM stage and occurrence of distant metastasis [28].…”

Section: Discussionmentioning

confidence: 99%

“…The association between high density lipoprotein-cholesterol (HDL-c) and cancer risk was also reported, including breast cancer [11,16], prostate and ovarian cancer [11]. In addition, similar correlation was also found between HDL-c levels and risk of gastrointestinal cancer, such as liver cancer [17,18], biliary tract cancer [19,20] and pancreatic cancer [11,21,22]. However, to the best of our knowledge, the role of HDL-c in IPMNs has not been investigated.…”

Section: Introductionmentioning

confidence: 88%

“…HDL potentially antagonizing two main hallmarks of cancer progression via its potent antioxidant and anti-in ammatory properties [14,15]. The association between high density lipoprotein-cholesterol (HDL-c) and cancer risk was also reported, including breast cancer [11,16], prostate and ovarian cancer [11]. In addition, similar correlation was also found between HDL-c levels and risk of gastrointestinal cancer, such as liver cancer [17,18], biliary tract cancer [19,20] and pancreatic cancer [11,21,22].…”

Section: Introductionmentioning

confidence: 90%

“…Cholesterol plays a critical role in cancer progression by enhancing cell proliferation, migration, and invasion [9]. High-density lipoprotein (HDL) is the main lipoprotein cholesterol transporter to the major steroidogenic organs [10,11]. HDL protects against cancer development through its pleiotropic properties, including anti-oxidation and modulating cytokine production, and by blocking apoptosis, cell-growth stimulation and migration [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Low HDL-Cholesterol is Associated with Malignant Intraductal Papillary Mucinous Neoplasms: A Multicenter Study

Wang¹,

Lin²,

Wang³

et al. 2021

Preprint

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Background: Intraductal papillary mucinous neoplasms (IPMNs) has the potential of malignant transformation. Previous studies showed that HDL-c was related to risk of cancer. In this study, we showed the association between HDL-c and the incidence of malignancy in IPMNs.Material and methods: 226 patients with histologically proven IPMNs who underwent surgery were included in the present study. 151 patients were assigned to training group andother 75 patients was set as a validation. Patients’ demographic information, clinical data, and pathological features were obtained from medical records. Those with high grade dysplasia and invasive carcinoma were defined as malignant IPMNs. Logistic regression analyses were used to show the association between HDL-cand malignant IPMNs. Receiver operating characteristic (ROC) curves were performed to show the predictive performance. Results: Prevalence of low HDL-c in patients with malignant IPMNs was higher than those with non-malignant IPMNs (p < 0.01) both in training group and validation group. Prevalence of malignant IPMNs was decreased with the increase of HDL-c both in all IPMNs and Branch-Duct IPMNs (BD-IPMNs).Logistic analysis showed that low HDL-c was associated with malignant IPMNs (OR =20.56, 95% CI:2.58 - 163.64) in all IPMNs and BD-IPMNs (OR = 17.6, 95%CI: 1.16-268.46).The predictive performance of mural nodule plus low HDL-c was higher than that of mural nodule alone or mural nodule plus cyst size in identifying malignant BD-IPMNs.Conclusion: HDL-c may be a potential biomarker for identifying malignant IPMNs. Moreover, HDL-c may improve the predictive ability of malignancy in BD-IPMNs.

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Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Yin

Song

et al. 2022

Cancer Communications

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Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5-year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection. Surgical resection represents the only chance for cure, but treatment options are limited for advanced diseases, such as distant metastatic or locally progressive tumors. Although adjuvant chemotherapy has improved long-term outcomes in advanced cancer patients, its response rate is low. So, exploring other new treatments is urgent. In recent years, increasing

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LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies

Cited by 36 publications

References 329 publications

Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: A multicenter study

Low HDL-Cholesterol is Associated with Malignant Intraductal Papillary Mucinous Neoplasms: A Multicenter Study

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

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