Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Abstract

Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5-year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection. Surgical resection represents the only chance for cure, but treatment options are limited for advanced diseases, such as distant metastatic or locally progressive tumors. Although adjuvant chemotherapy has improved long-term outcomes in advanced cancer patients, its response rate is low. So, exploring other new treatments is urgent. In recent years, increasing

Prognostic Value for Perioperative Serum Total Cholesterol Level on Postoperative Long-Term Prognosis of Pancreatic Cancer: A Retrospective Clinical Study

“…Lipid metabolism reprogramming is common in pancreatic cancer tissue and has been identified as an important characteristic of pancreatic cancer. Cholesterol is essential for rapidly expanding pancreatic cancer cells due to its involvement in cell membrane synthesis, signal transduction and energy supply [ 14 ]. Current research has not only revealed the correlation between the progression and drug resistance of pancreatic cancer and cholesterol but also demonstrated that tumors increase the uptake of exogenous cholesterol by increasing LDL receptors on the surface of cancer cells so as to meet their high avidity for cholesterol [ 23 ].…”

“…Its predictive value may be attributed to its close correlation with tumor biological behavior and perioperative nutritional status, perioperative immune function, oxidative stress level and secretion of inflammatory factors such as IL-6 [ 13 ]. As for pancreatic cancer, it has been reported that the occurrence and progression of pancreatic cancer are related to abnormal lipid absorption and metabolism [ 14 ]. Patients with pancreatic cancer usually suffer from malnutrition, major surgical trauma, severe postoperative systemic inflammation and perioperative complications that may affect the serum TC level.…”

ELOVL2, a novel and potential tumor antigen guided mRNA vaccine development for retroperitoneal liposarcoma

“…Aberrant lipid metabolism and lipid metabolism reprogramming are critically involved in drug resistance [6], the adaptation of immune microenvironment [7], energy supplement, cell signaling[8] and regarded as a new hallmark of tumor ecosystem [9]. Emerging evidence indicated that targeting the lipid metabolism pathway was an attractive tumor treatment strategy [10]. Previous studies have indicated that lipid metabolism-associated genes (LMAGs) exhibit potent capability in predicting the prognosis of various tumors [11][12][13][14].…”

Orderly Aggregated Catalytic Hairpin Assembly for Synchronous Ultrasensitive Detecting and High-Efficiency Co-Localization Imaging of Dual-miRNAs in Living Cells

“…12−15 Previous studies have demonstrated that miRNA-196a is significantly upregulated but miRNA-217 is markedly downregulated in PDAC, while miRNA-217 was highly expressed and miRNA-196a was low expressed in normal pancreas. 16 Therefore, exploring simultaneous ultrasensitive detection and precise colocalization imaging of miR-217 and miR-196a in living cells holds immense importance in the early diagnosis of pancreatic cancer and ensure detection specificity. In the same time, synchronous detection of dual-targets avoids the tedious operation of multiple tests and mitigates the expenses associated with detection.…”

“…MicroRNAs (miRNAs) are a kind of single-stranded noncoding RNA composed of 18–24 nucleotides, which participate in the regulation of many physiological processes by controlling mRNA translation. – A great deal of research evidence identify that the imbalance of specific miRNA expression is closely related to the occurrence of cancer or other pathological conditions, so some specific miRNAs have been identified as biomarkers for cancer diagnosis, therapy, and prognosis. – Pancreatic ductal adenocarcinoma (PDAC) is considered to be one of the mortal neoplasms with the worst prognosis, which is difficult to diagnose at an early stage. – Previous studies have demonstrated that miRNA-196a is significantly upregulated but miRNA-217 is markedly downregulated in PDAC, while miRNA-217 was highly expressed and miRNA-196a was low expressed in normal pancreas . Therefore, exploring simultaneous ultrasensitive detection and precise colocalization imaging of miR-217 and miR-196a in living cells holds immense importance in the early diagnosis of pancreatic cancer and ensure detection specificity.…”