LDL-C/HDL-C ratio associated with carotid intima-media thickness and carotid plaques in male but not female patients with type 2 diabetes

Du, Rong; Li, Mingxia; Wang, Xi; Wang, Suyuan; Li, Sheyu; Tian, Huayu; Wu, Yunhong; Zhang, Chenghui

doi:10.1016/j.cca.2020.10.014

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…This finding is in line with LDL-C-targeting lipid-lowering trials (23). LDL-C/HDL-C is a good predictor of cardiovascular events and atherosclerosis (24,25). However, few lipid-lowering drugs elevate HDL-C with cardiovascular benefits (26).…”

Section: Discussionsupporting

confidence: 68%

Different Lipid Parameters in Predicting Clinical Outcomes in Chinese Statin-Naïve Patients After Coronary Stent Implantation

Zeng

et al. 2021

Front. Cardiovasc. Med.

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Background: Low-density lipoprotein cholesterol (LDL-C) is a critical surrogate outcome for cardiovascular disease (CVD). Recent observational studies identified different predictive lipid parameters, but these have not been fully validated in the Chinese population. This study aimed to compare the predictive value of lipid parameters for cardiovascular outcomes in Chinese statin-naïve patients who underwent percutaneous coronary intervention (PCI).Methods: We retrospectively recruited statin-naïve patients who underwent PCI for stable angina and acute coronary syndrome at Sichuan Provincial People's Hospital between 1 January 2016 and 31 December 2017. A follow-up was conducted via outpatient visits or telephone. We divided patients into three groups based on lipid parameter tertiles. We calculated the hazard ratios (HRs) of the highest and lowest tertiles for major adverse cardiovascular events (MACEs) using multivariate Cox proportional hazards regression. We compared the association strength of lipid parameters with MACEs using the HR of non-LDL-C lipid parameters relative to LDL-C.Results: Among 445 included patients, the highest LDL-C, LDL-C/high-density lipoprotein cholesterol (HDL-C), atherosclerosis index, and non-HDL-C level tertiles were associated with an average increase of 165% (HR 2.65, confidence interval [CI] 1.26 to 5.61; P = 0.01), 324% (HR 4.24, CI 1.89 to 9.52; P < 0.001), 152% (HR 2.52, CI 1.22 to 5.22; P = 0.01), and 125% (HR 2.25, CI 1.09 to 4.64; P = 0.01) in the hazard of composite CVD, respectively. Lipoprotein (a) levels did not show a significant association with the endpoints. Except for LDL-C/HDL-C, different lipid parameter HR ratios were <1.0; none were statistically significant.Conclusion: Compared with non-LDL-C lipid parameters, LDL-C acts better predictive value for cardiovascular outcomes in general Chinese statin-naïve post-PCI patients.

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Section: Discussionsupporting

confidence: 68%

Different Lipid Parameters in Predicting Clinical Outcomes in Chinese Statin-Naïve Patients After Coronary Stent Implantation

Zeng

et al. 2021

Front. Cardiovasc. Med.

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“…Previous studies described high LDL/HDL ratio is a significant predictor of the degree of carotid atherosclerosis. It also has been suggested that LDL-/HDL ratio showed a positive and linear relationship with the carotid plaques in diabetics 17 . A prospective cohort study also verified that LDL/HDL ratio is a better predictor of carotid intima media thickness progression than either HDL or LDL levels alone 18 .…”

Section: Discussionmentioning

confidence: 98%

Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor

Talat¹,

Shoaib²,

Sabir³

et al. 2021

PJMHS

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Aim: To determine Leptin/Adiponectin ratio, LDL/HDL ratio and AdipoR1 in obese and healthy subjects along with their respective lipid status. Methods: This cross-sectional comparative study was conducted in Sialkot city. One hundred and thirty-two participants took part in this research. Participants were equally divided into two groups containing non-obese and obese subjects. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while non-obese group BMI was 20.5±0.2. Individuals with conditions and history of drugs were excluded. Informed and written consent was obtained prior to fasting blood sampling. Serum extraction and proper storage for later testing was carried out. ELISA method used for Adiponectin, AdiopR1 and leptin estimations while lipid profile was determined by Randox Diagnostics kits, using micro lab. SPSS v. 26. was used for comparison between by Mann-Whitney U tes. Results: Higher levels of Leptin/Adiponectin ratio(0.85±0.1) and LDL/HDL ratio (3.39 ± 0.1), serum Adiponectin (545± 73.3 ug/L), leptin (320.7±50.3 pg/mL) and AdipoR1 (28.9± 2.8 ng/mL) in obese when compared with healthy individuals, Leptin/Adiponectin ratio (0.44 ± 0.07 ) and LDL/HDL ratio (2.56 ± 0.08) Adiponectin (834± 70.6 ug/L), AdiopoR1 (17.8± 1.97 ng/mL), leptin (224.4±168.7 pg/mL). Correlation of adiponectin found positive for AdipoR1(r=0.336,p<0.05) and Leptin(r=0263,p<0.05) in obese subjects. L/A ratio correlated positive with leptin (r=0.644,p<0.05) in obese while in healthy subjects (leptin r=0.409,p<0.05,adiponectin r=-0.408,p<0.05 and HDL r=0.266,p<0.05).. Conclusion: The Leptin/Adiponectin ratio was found higher in obese subjects 0.85 as compared to healthy ones 0.44. Also the LDL/HDL ratio was found higher (3.39) when compared to non-obese (2.56), suggesting these ratios as a suitable marker to estimate metabolic disturbances and underlying dyslipidemia in the obese subjects. Key Words: Adiponectin, LDL/HDL ratio, Leptin, Leptin/Adiponectin ratio, Obesity

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“… 68 – 72 This ratio determination has also been shown to be a better predictor of CIMT advancement than HDL-C or LDL-C alone in a prospective investigation. 73 , 74 …”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia and associated cardiovascular risk factors in HIV-positive and HIV-negative patients visiting ambulatory clinics: A hospital-based study

Woldu

Minzi

Engidawork

2022

JRSM Cardiovascular Disease

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Background Dyslipidemia is a well-known risk factor for cardiovascular disease (CVD), accounting for more than half of all instances of coronary artery disease globally (CAD). Purpose The purpose of this study was to determine lipid-related cardiovascular risks in HIV-positive and HIV-negative individuals by evaluating lipid profiles, ratios, and other related parameters. Methods A hospital-based study was carried out from January 2019 to February 2021 in both HIV + and HIV- ambulatory patients. Results High TG (p = .003), high TC (p = .025), and low HDL (p < .001) were all associated with a two-fold increased risk of CVD in people aged 45 and up. Due to higher TG (p < .001) and lower HDL (p < .001), males were found to have a higher risk of atherogenic dyslipidemia. A twofold increase in the likelihood of higher TG levels has been associated with smoking (p = .032) and alcohol intake (p = .022). A twofold increase in a high TC/HDL ratio and an elevated TG/HDL ratio was observed with an increase in waist-to-height ratio (p = .030) and a high level of FBS (126 mg/dl) and/or validated diabetes (p = .017), respectively. In HIV + participants, central obesity (p < .001), diabetes (p < .001), and high blood pressure (p < .001) were all less common than in HIV- participants. Conclusions Dyslipidemia is linked to advanced age, male gender, diabetes, smoking, alcohol consumption, and increased waist circumference, all of which could lead to an increased risk of CVD, according to the study. The study also revealed that the risks are less common in HIV + people than in HIV-negative ambulatory patients.

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LDL-C/HDL-C ratio associated with carotid intima-media thickness and carotid plaques in male but not female patients with type 2 diabetes

Cited by 14 publications

References 35 publications

Different Lipid Parameters in Predicting Clinical Outcomes in Chinese Statin-Naïve Patients After Coronary Stent Implantation

Different Lipid Parameters in Predicting Clinical Outcomes in Chinese Statin-Naïve Patients After Coronary Stent Implantation

Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor

Dyslipidemia and associated cardiovascular risk factors in HIV-positive and HIV-negative patients visiting ambulatory clinics: A hospital-based study

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