LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes

Köse, Leyla Polat; Gülçın, İlhami; Goren, Ahmet C.; Namieśnik, Jacek; Martínez-Ayala, Alma Leticia; Gorinstein, Shela

doi:10.1016/j.indcrop.2015.05.034

Cited by 233 publications

(98 citation statements)

References 85 publications

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“…Hence, there is a growing interest in exploring, purifying, and characterization of natural sources of natural and safer antioxidants for food and pharmaceutical applications. [20][21][22] Origanum minutiflorum is an endemic plant found in the mountains of southern Turkey. It is used as a spice for seasoning, as a herbal tea, and also as a medicinal herb for curing stomach-aches and respiratory colds.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

Elmastaş

Celik

Genç

et al. 2018

International Journal of Food Properties

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Origanum species are significant aromatic and medicinal plants used in food and pharmaceutical industries. Isolation of bioactive compounds was executed on n-butanol extract to yield the compounds responsible for the activities. Tricosan-1-ol (1), (8E,16E)-tetracosa-8,16-diene-1,24-diol (2), azepan-2-one (3), 3,4-dihydroxybenzoic acid (4), apigenin (5), eriodictyol (6), globoidnan-A (7), luteolin (8), rosmarinic acid (9), apigenin-7-O-glucuronide (10), and vicenin-2 (11) were isolated by chromatographic methods (column chromatography and semi-preparative High Performance Liquid Chromatography (HPLC) and structures were elucidated on the basis of spectroscopic techniques including 1D/2D nuclear magnetic resonance (NMR) and Liquid chromatography/Time-of-flight/Mass spectrometry (LC-TOF/MS). The isolated compounds and extracts were applied for antioxidant assays including 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS •+ ) scavenging, reducing power, and cuprac techniques. 3,4-Dihydroxy benzoic acid (4), eriodictyol (6), luteolin (8), and rosmarinic acid (9) revealed the considerable antioxidant activities. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

Elmastaş

Celik

Genç

et al. 2018

International Journal of Food Properties

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“…Galangal also used as traditional medicine. It could treat gastrointestinal disordes, eliminate bloating, infection, and potential for curing cancer because of its antioxidant activity (chemoprevention) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Optimation of Ethanol Concentration in Extraction of Eugenol From Galangal Rhizome

Yugatama

Ardiyati

Yulianti

2017

Asian J Pharm Clin Res

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Objective: The main objective of this study was to determine the optimal ethanol concentration as solvent for extracting eugenol from galangal.Methods: Galangal rhizome extraction was conducted with kinetic maceration at 50°C with various ethanol concentration as solvent (0%, 30%, 50%, 70%, and 96%). A 1:10 ratio of rhizome and ethanol was applied. The extract was obtained, then its eugenol concentration was analyzed qualitatively and quantitatively by thin-layer chromatography-densitometer with n-hexane:ethyl acetate (4:1) by using mobile phase and silica gel 60 F 254 as stationary phase and applying a wavelength of 283 nm. Results:The result of qualitative analysis showed that extract of 70% and 96% ethanol had a spot with Rf value 0.63, which was equal to the Rf value of standard eugenol. Standard curve equation for the 70% ethanol extract was y=89318x+656.07 (r=0.9993) and for the 96% ethanol extract was y=8658x+1743 (r=0.9999). The result of the quantitative analysis showed that the 70% and 96% ethanol extract contained 4.85% and 4.79% eugenol, respectively. Conclusion:Extraction of galangal rhizome in 70% and 96% ethanol was positively containing eugenol. Highest eugenol concentration (4.85%) was obtained from galangal rhizome extraction in 70% ethanol.

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“…Acetylcholinesterase (AChE) is a crucial enzyme used for transmission control between neurons [36] when the process is either mediated or modulated by the neurotransmitter acetylcholine (ACh). ACh is released by the axon terminal or varicosities of the transmitter neuron into the extracellular space to interact with the receptors of the other neuron.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan β-Lactam Derivatives

Genc

Kalın

Köksal

et al. 2016

IJMS

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β-Lactams are pharmacologically important compounds because of their various biological uses, including antibiotic and so on. β-Lactams were synthesized from benzylidene-inden derivatives and acetoxyacetyl chloride. The inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The results reveal that β-lactams are inhibitors of hCA I, II and AChE. The Ki values of β-lactams (2a–k) were 0.44–6.29 nM against hCA I, 0.93–8.34 nM against hCA II, and 0.25–1.13 nM against AChE. Our findings indicate that β-lactams (2a–k) inhibit both carbonic anhydrases (CA) isoenzymes and AChE at low nanomolar concentrations.

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LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes

Cited by 233 publications

References 85 publications

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

Optimation of Ethanol Concentration in Extraction of Eugenol From Galangal Rhizome

Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan β-Lactam Derivatives

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