LC–MS Determination of remifentanil in maternal and neonatal plasma

Remifentanil for cesarean section under general anesthesia: effects on maternal stress hormone secretion and neonatal well-being: a randomized trial

“…Remifentanil plasma concentrations were determined by a validated HPLC-MS method after solid phase extraction. 16 The quantitation range of the assay was 0.5 to 48.0 ng/mL; the estimated limit of detection was 0.18 ng/mL, and the limit of quantitation was 0.5 ng/mL.…”

Determination of remifentanil in human plasma by liquid chromatography–tandem mass spectrometry utilizing micro extraction in packed syringe (MEPS) as sample preparation

“…It is used for obstetric analgesia as a supplement to general anaesthesia during induction and as an analgesic during maintenance of anaesthesia [1,2]. Remifentanil is not metabolised in the liver unlike other compounds from the same family [3].…”

Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography–tandem mass spectrometry

“…Comparison of this method to earlier LC-MS/MS methods revealed that the LOQs obtained here for most of the compounds were essentially at the same level or better [8][9][10][12][13][14][15][16][22][23][24][25][26]. Markedly higher LOQs were obtained for fentanyl (0.0001 mg/L), norfentanyl (0.007 mg/ L), sufentanil (0.0002 mg/L), and 6-monoacetylmorphine (0.003 mg/L), however, for which the earlier reported LOQs values were 0.000025 mg/L [12], 0.00005 mg/L [12,13], 0.00001 mg/L [15], and 0.00025 mg/L [26], respectively.…”

“…In the recent GC-MS methods, solid phase extraction (SPE) and selected ion monitoring (SIM) were applied [4][5][6][7], for which the reported limits of quantification (LOQ) for fentanyl and sufentanil were as low as 0.0025 ng/mL. In the recently described LC-MS/MS methods, the analysis usually included one to four fentanyls [8][9][10][11][12][13][14][15][16]. Only one A method for simultaneous screening and quantification was developed for the fentanyls alfentanil, fentanyl, p-fluorofentanyl, cis-3-methylfentanyl, trans-3-methylfentanyl, alpha-methylfentanyl, norfentanyl, remifentanil, sufentanil, and the other opioid drugs 6-acetylmorphine, buprenorphine, codeine, dextropropoxyphene, ethylmorphine, heroin, methadone, morphine, naloxone, naltrexone, norbuprenorphine, normethadone, oxycodone, pentazocine, pethidine, and tramadol in post-mortem blood and urine samples by LC-MS/MS.…”