LC method for the analysis of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension

Morsch, Lisoni Muller; Bittencourt, Celso Figueiredo; Souza, Marinês Jost e; Milano, Julie

doi:10.1016/s0731-7085(02)00343-6

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…This is consistent with many reports about the comparison of PO and IV administrations (Castro et al 2009;Militano et al 2009;Albarellos et al 2011). In the last few years, one of the major advances in the field of antimicrobial therapy has been the cephalosporins, the oral derivatives of the aminocephalosporanic ring (Morsch et al 2002). However, cephalosporins can hardly cross the lipid membranes, such as the intestinal mucosa, due to their poor lipid solubility.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog

Wang

Zhu

Wang

et al. 2014

Eur J Drug Metab Pharmacokinet

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The pharmacokinetic (PK) and pharmacodynamic (PD) properties of intravenously (IV) administered cefetamet-Na and per os (PO) administered cefetamet pivoxil were investigated in eighteen healthy dogs at three different dose levels. The three doses for IV cefetamet-Na were 95, 190 and 380 mg, while those for oral cefetamet pivoxil were 125, 250 and 500 mg (both equivalent to 90, 180 and 360 mg of cefetamet). An efficacy predictor, measured as the ratios of the time that the concentration of the free drug is over the MIC90 (T > MIC90) and the dosing interval (f% T > MIC90) of IV and PO administration were calculated. The PK parameters' maximum concentration (C max), half-life (t 1/2) and area under the curve (AUC0-t ) after three IV doses were 42.85 ± 11.79 μg/mL, 1.66 ± 0.36 h and 80.10 ± 28.92 mg h/L (95 mg); 93.50 ± 30.51 μg/mL, 1.47 ± 0.13 h and 1.47 ± 0.13 mg h/L (190 mg); 185.74 ± 113.83 μg/mL, 1.60 ± 0.38 h and 263.20 ± 73.27 mg h/L (380 mg). After PO administration, the C max, t 1/2 and AUC0-t at three doses were 9.25 ± 1.02 μg/mL, 1.79 ± 0.50 h and 31.90 ± 4.76 mg h/L (125 mg); 9.75 ± 1.77 μg/mL, 1.93 ± 0.65 h and 42.69 ± 8.93 mg h/L (250 mg); 15.55 ± 6.65 μg/mL, 2.02 ± 0.54 h, and 68.72 ± 24.11 mg h/L (500 mg). The IV f% T > MIC90 was greater than PO f% T > MIC90 when MIC90 was within the range of 0.25-256 mg/L.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog

Wang

Zhu

Wang

et al. 2014

Eur J Drug Metab Pharmacokinet

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“…The limit of detection (LOD) and the limit of quantification (LOQ) were separately determined by diluting the standard concentrations [16][17][18]. Accuracy and precision was assessed using three replicates of three concentrations in the range and with six replicates for 100% drug release (i.e., 20 g/ml), in each medium.…”

Section: Methods Validationmentioning

confidence: 99%

Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of oxybutynin immediate-release and controlled-release formulations

Varma

Kaushal

Garg

2004

Journal of Pharmaceutical and Biomedical Analysis

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“…The reviewed methods include analysis of Cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension, spectrophotometric estimation of Cefetamet pivoxil in pharmaceutical formulation and reported few chromatographic methods in bulk, powders and other pharmaceutical dosage forms. [3][4][5] In the present analytical research, an attempt has been made to develop and validate suitable, simple, precise, robust, rugged and accurate chromatographic RP-HPLC method for estimation of Cefetamet pivoxil in bulk and tables. [6][7][8][9] Fig.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic estimation of cefetamet pivoxil in bulk and tablet dosage form: Development and validation approach

Palled¹,

Bhanusali²,

Suryawanshi³

2022

IJPCA

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Cefetamet pivoxil is an oral third generation cephalosporin class of antibiotic which is mainly used in the treatment and management of both upper and lower community acquired respiratory tract infection. Many branded and generic formulations are available in tablet dosage forms in market, hence the quality control of Cefetamet pivoxil play an important role in pharmaceutical industry. In the present research work an attempt has been made to develop and validate cost effective, simple, precise, robust and rugged chromatographic method for estimation of Cefetamet pivoxil in bulk and tablets. Chromatographic method was developed using HPLC instrument. The separation was based on isocratic reverse phase chromatographic mode using C-18 column as stationary phase and mobile phase composed of acetonitrile: water (80:20 v/v) at ambient temperature using UV detection at 251 nm. Developed method was validated by analyzing parameters such as specificity, selectivity, linearity, range, precision, robustness, ruggedness, detection limit, quantification limit and drug recovery. All the method validation reportwas found to be within the acceptance as per ICH guidelines. Linearity was found between the range of 10 – 50 mg/ml. The results obtained from the validation data showed that method was specific, selective, linear, precise, accurate, robust and rugged and hence can be used for estimation of Cefetamet pivoxil in bulk and tablets dosage forms.

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LC method for the analysis of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension

Cited by 8 publications

References 8 publications

Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog

Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog

Rapid and selective UV spectrophotometric and RP-HPLC methods for dissolution studies of oxybutynin immediate-release and controlled-release formulations

Chromatographic estimation of cefetamet pivoxil in bulk and tablet dosage form: Development and validation approach

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