Lc/Icp‐ms and Complementary Techniques in Bespoke and Nontargeted Speciation Analysis of Elements in Food Samples

Abstract

Chemical elements speciation analysis of food samples has been among the most important scientific topics over the last decades. Food samples are comprised of high variety of chemical compounds, from which many can interact with metals and metalloids, forming complex elemental species with various influence on the human body. It is particularly important not only to determine the amount of certain chemical element in food sample but also to identify the form in which given element occurs in given sample. Employment of bespoke and nontargeted speciation methods, with the use of liquid chromatography inductively coupled plasma mass spectrometry (LC/ICP-MS) and complementary techniques, provides more complete picture on the metals and metalloids speciation in food. This review discusses issues concerning speciation analysis of metals and metalloids in food samples with the use of LC/ ICP-MS as a leading technique in elemental speciation nowadays and a complimentary technique intended for their identification.

A vision on the ‘foodture’ role of dietary exposure sciences in the interplay between food safety and nutrition

“…(Patriarca et al, 2021)), the implementation and application in monitoring laboratories is still lagging behind (Lehotay & Chen, 2018). In the area of trace elements, the capability to distinguish species with markedly different biological and toxicological properties (e.g., by LC-ICP-MS (Lorenc et al, 2020)) is still largely limited to expert laboratories whereas in these cases speciation analysis is key for both risk assessment and risk management.…”

Elution with 1,2-Hexanediol Enables Coupling of ICPMS with Reversed-Phase Liquid Chromatography under Standard Conditions

“…Furthermore, the increased complexity and reduced convenience associated with the organic ICPMS mode has apparently been a deterring factor in many nontargeted analysis studies where low organic content mobile phases were employed, , and for some elements, this has likely lead to a gap (i.e., low column recovery) between the total elemental content and the sum of the individual species detected. − It is plausible that the inclusion of mobile phases with higher elution strength in nontargeted screening speciation analyses using high-performance liquid chromatography (HPLC)-ICPMS on a routine basis would enable the identification of more novel compounds.…”

Rapid automated total arsenic and arsenic speciation by inductively coupled plasma mass spectrometry

“…4 Arsenic is or has been used in pesticides, herbicides, food additives, drugs, poisons, and chemical weapons. [4][5][6] Arsenic can be found in many different chemical forms. The inorganic forms, arsenite (As(III)) or arsenate (As(V)), are more toxic due to higher bioavailability.…”