Rapid automated total arsenic and arsenic speciation by inductively coupled plasma mass spectrometry

Abstract

Rapid automated analysis of total arsenic and arsenic species by LC-ICP-MS. One- and two-column separation methods were developed and validated for arsenic speciation in urine samples.

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…Procedures for the fast separation of As species in urine by HPLC-ICP-MS were further investigated by Quarles et al 85 This group proposed a method (A) based on anion-exchange chromatography, that would allow the separation of As III , As V , AB, AC, DMA and MMA, within 2 min, as well as an alternative procedure (B), using an additional C18 column, for the determination of TMAO in addition to the other species, within a slightly longer time frame (4.5 min). In both cases, an automated system (prepFAST IC, Elemental Scientific) was used, that included an autosampler, the ability to dilute standards and samples inline to the ICP-MS and to switch the sample introduction between different options (no column, one column, two columns).…”

“…Low sensitivity was observed for GC-EI-MS/MS, despite its higher selectivity, and this method could not be recommended for routine use. Two rapid automated arsenic speciation methods in urine were developed by Quarles et al 85 One separated and detected six As species using a single column with an impressive separation time of around 2 min, while the second method utilised an additional column to also separate TMAO, which increased the separation time to approximately 4.5 min. In urine, LODs ranged from 2.8 to 9.1 ng L −1 and recoveries for the As species were between 94% and 107%.…”

Atomic spectrometry update: review of advances in elemental speciation

“…However, the separations are often lengthy or do not resolve all the species of interest. Quarles et al 28 have developed methodology for the rapid separation of AB, As III , As V , DMA, AC, MMA, and TMAO using an automated two column system, with (NH 4 ) 2 CO 3 as the eluent and ICP-MS detection, for the separation of As III , As V , DMA, AC, MMA. This separation was optimised to 2 minutes using a gradient step of 0.5 mmol L −1 ammonium carbonate followed by 80 mmol L −1 ammonium carbonate with AEC.…”

Towards Automated and High-Throughput Quantitative Sizing and Isotopic Analysis of Nanoparticles via Single Particle-ICP-TOF-MS

“…Xu et al utilized a novel sample introduction platform to minimize sample volumes of plutonium metal samples by approximately 90% by introducing the sample via syringe drive in conjunction with a sample loop (as opposed to traditional aspiration), while improving the method detection limit (by approximately 50×) [9]. Aside from nuclear analytical chemistry [10,11], other applications emphasizing improved automation and sample delivery have been particularly useful in terms of ICP-MS-based analysis, including speciation [12], stable isotope analysis [13], and clinical studies [14,15].…”