LC and TLC determination of cinnarizine in pharmaceutical preparations and serum

Hassan, Saad S. M.; Elmosallamy, Mohamed A. F.; Abbas, Alaa B.

doi:10.1016/s0731-7085(01)00662-8

Cited by 26 publications

(11 citation statements)

References 12 publications

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“…The drug concentration for in vitro study was analyzed by validated high-performance liquid chromatography (HPLC) method using a reverse-phase microparticulate C18 (Bondapak C18, particle size 5 µm, 30 cm×4 mm column Waters Associate, Milford, MA, USA) (16). The mobile phase was prepared by mixing acetate buffer (20 ml glacial acetic acid, adjusted to pH 4) and methanol (30:70) at a flow rate of 1.5 ml/min.…”

Section: High-performance Liquid Chromatography Proceduresmentioning

confidence: 99%

In Vitro Release Kinetics and Bioavailability of Gastroretentive Cinnarizine Hydrochloride Tablet

Nagarwal

Ridhurkar²,

Pandit

2010

AAPS PharmSciTech

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Abstract. An oral sustained release dosage form of cinnarizine HCl (CNZ) based on gastric floating matrix tablets was studied. The release of CNZ from different floating matrix formulations containing four viscosity grades of hydroxypropyl methylcellulose, sodium alginate or polyethylene oxide, and gasforming agent (sodium bicarbonate or calcium carbonate) was studied in simulated gastric fluid (pH 1.2). CNZ release data from the matrix tablets were analyzed kinetically using Higuchi, Peppas, Weibull, and Vergnaud models. From water uptake, matrix erosion studies, and drug release data, the overall release mechanism can be explained as a result of rapid hydration of polymer on the surface of the floating tablet and formation of a gel layer surrounding the matrix that controls water penetration into its center. On the basis of in vitro release data, batch HP1 (CNZ, HPMC-K100LV, SBC, LTS, and MgS) was subjected to bioavailability studies in rabbits and was compared with CNZ suspension. It was concluded that the greater bioavailability of HP1 was due to its longer retention in the gastric environment of the test animal. Batch no. HP1 of floating tablet in rabbits demonstrated that the floating tablet CNZ could be a 24-h sustained release formulation.

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Section: High-performance Liquid Chromatography Proceduresmentioning

confidence: 99%

In Vitro Release Kinetics and Bioavailability of Gastroretentive Cinnarizine Hydrochloride Tablet

Nagarwal

Ridhurkar²,

Pandit

2010

AAPS PharmSciTech

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“…2,6,7 (RP-HPLC) methods have been developed for quantitative estimation of CIN. One HPTLC method has been reported for the simultaneous estimation of CIN and Domperidone maleate by Argekar et al In referred scientific literature no HPTLC method has been found for the estimation of CIN as single chemical entitiy.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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High performance thin layer chromatography (HPTLC) offers many advantages over HPLC. It reduces the cost of analysis as compared to HPLC. The mobile phase consumption per sample is extremely low in HPTLC, hence reducing the acquisition and disposal cost. Considering the cost and suitability of analysis for estimation of cinnarizine in bulk and its marketed formulation, HPTLC method was developed and validated. The Camag HPTLC system, employed with software win CATS (ver.1.4.1.8) was used for proposed analytical work. Planar chromatographic development was carried out with the help of Silica Gel 60 F254precoated TLC plates. Sample application was facilitated by Linomat 5 applicator. After sample application plates were subjected for ascending development in twin trough chamber of 10x10 cm dimension, using 10 ml of solvent system. The optimized mobile phase was composed of toluene: ethanol (7.5:2.5 v/v). In post development, the plates were air dried and then scanned densitometrically using a UV detector at 254 nm in absorbance mode. In HPTLC densitogram well defined peak was obtained for cinnarizine with starting position at 0.69 R f , max position at 0.72 R f and end position at 0.75 Rf. The optimal R f value for cinnarizine was found to be 0.72. Performance characteristics of HPTLC method for estimation of cinnarizine in bulk and its marketed dosage form were statistically validated as per recommendations of ICH guidelines of analytical method validation. The HPTLC method was found to be linear across the range 50-400 ng/band. The LOD and LOQ values were found to be 0.05162 and 0.1564 ng/band respectively. The method was found to be accurate, precise, robust and economical for the analysis of cinnarizine from bulk and its formulation.

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“…In addition, some spectrophotometric [6,7] chromatographic [8][9][10][11] methods have been reported in the literature for the determination of either DIM or CIN in pharmaceutical formulations, biological samples and with other drugs in combination. Few methods have been reported for analysis of the cited drugs in their binary mixture, including classical derivative, derivative ratio, Q absorbance ratio and bivariate spectrophotometric methods [12][13][14] and other chromatographic [15,16] methods.…”

Section: Introductionmentioning

confidence: 99%

Development of normalized spectra manipulating spectrophotometric methods for simultaneous determination of Dimenhydrinate and Cinnarizine binary mixture

Lamie

Yehia

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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LC and TLC determination of cinnarizine in pharmaceutical preparations and serum

Cited by 26 publications

References 12 publications

In Vitro Release Kinetics and Bioavailability of Gastroretentive Cinnarizine Hydrochloride Tablet

In Vitro Release Kinetics and Bioavailability of Gastroretentive Cinnarizine Hydrochloride Tablet

Untitled

Development of normalized spectra manipulating spectrophotometric methods for simultaneous determination of Dimenhydrinate and Cinnarizine binary mixture

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