Development of normalized spectra manipulating spectrophotometric methods for simultaneous determination of Dimenhydrinate and Cinnarizine binary mixture

Lamie, Nesrine T.; Yehia, Ali M.

doi:10.1016/j.saa.2015.05.048

Cited by 27 publications

(12 citation statements)

References 14 publications

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“…This method was then modulated to be simultaneous by coupling with amplitude modulation theory to generate simultaneous derivative ratio method (S 1 DD) [16]. In S 1 DD after division by the normalized spectra of PCT and before the derivatization step took place, the amplitude at isoabsorptive point (263.6 nm) was determined representing the actually concentration of CAF and/or PCT.…”

Section: Resultsmentioning

confidence: 99%

“…Derivative transformation [12], spectrum subtraction [13], amplitude factor [14], advanced absorbance subtraction method (AAS) [15], advanced amplitude modulation method (AAM) [15] and simultaneous derivative ratio (S 1 DD) [16] are well developed method that were successfully adopted for resolution of overlapped spectra of binary mixtures.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

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Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Mohamed

Lotfy

Hegazy

et al. 2017

Chemistry Central Journal

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BackgroundAnalysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different novel and smart spectrophotometric techniques for resolution of severely overlapping spectra were presented in this work utilizing isosbestic points present in different absorption spectra, normalized spectra as a divisor and dual wavelengths. A quaternary mixture of drotaverine (DRO), caffeine (CAF), paracetamol (PCT) and para-aminophenol (PAP) was taken as an example for application of the proposed techniques without any separation steps. The adopted techniques adopted of successive and progressive steps manipulating zero /or ratio /or derivative spectra. The proposed techniques includes eight novel and simple methods namely direct spectrophotometry after applying derivative transformation (DT) via multiplying by a decoding spectrum, spectrum subtraction (SS), advanced absorbance subtraction (AAS), advanced amplitude modulation (AAM), simultaneous derivative ratio (S1DD), advanced ratio difference (ARD), induced ratio difference (IRD) and finally double divisor–ratio difference-dual wavelength (DD-RD-DW) methods.ResultsThe proposed methods were assessed by analyzing synthetic mixtures of the studied drugs. They were also successfully applied to commercial pharmaceutical formulations without interference from other dosage form additives. The methods were validated according to the ICH guidelines, accuracy, precision, repeatability, were found to be within the acceptable limits.ConclusionThe proposed procedures are accurate, simple and reproducible and yet economic. They are also sensitive and selective and could be used for routine analysis of complex most of the binary, ternary and quaternary mixtures and even more complex mixtures.

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Section: Resultsmentioning

confidence: 99%

Section: Theoretical Backgroundmentioning

confidence: 99%

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Mohamed

Lotfy

Hegazy

et al. 2017

Chemistry Central Journal

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“…The normalized spectrum of the divisor is used and hence no need for the tedious step of choosing the optimum concentration of divisor. This method is used in the determination of Orphenadrine and Paracetamol in tablets [24], Dimenhydrinate and Cinnarizine [25] in a combined dosage form.…”

Section: Applicationsmentioning

confidence: 99%

Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Gummadi

Ganapaty

Almas

2018

Int J Pharm Pharm Sci

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The spectrophotometric multi-component analysis involves spectrum recording and mathematical equations. However, spectral interference poses a major limitation when mixture samples are encountered. To overcome this derivative spectrophotometry (DS) has been introduced for the resolution of overlapping peaks. In this review modified methods like derivative quotient spectra, double divisor ratio spectra derivative method, double divisor means centering of ratio spectra method, derivative subtraction coupled with the constant multiplication method (DS-CM), amplitude subtraction (AS), modified amplitude subtraction (MAS), amplitude factor method (P-Factor), amplitude modulation method (AM), amplitude summation method (A-Sum), simultaneous derivative ratio spectrophotometry (S1DD), derivative compensation ratio via regression equation, differential dual wavelength (D1 DWL), differential derivative ratio (D1DR), successive derivative subtraction method (SDS) and derivative transformation (DT) of derivative spectrophotometry theories and applications are reviewed. These methods were applied to solve different complex pharmaceuticals mixtures. These developed methods were simple and cost-effective.

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“…Literature review revealed that several analytical methods were reported for the spectrophotometric determination of CIN in pharmaceutical preparations and biological fluids. These methods include spectrophotometric [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], and spectroflorometric [20][21][22], voltammetry [23], high-performance liquid chromatography (HPLC) [9,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41], high-performance thin-layer chromatography (HPTLC) [9,[41][42][43][44][45], and capillary electrophoresis [46]. Other methods were developed to determination of CIN in combination with PCM which include spectrophotometry [47], high-performance liquid chromatography (HPLC) and high-performance thin layer chromatography, (HPTLC)...…”

Section: Introductionmentioning

confidence: 99%

Validated Spectrophotometric Methods for the Estimation of Cinnarizine in Binary Mixture With Paracetamol in Bulk and Tablets

Al-Ghani

Thabet

2021

Asian J Pharm Clin Res

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Objectives: The aim of this work was to develop and validate new, simple, accurate, and selective spectrophotometric methods (derivative and derivative ratio spectrophotometric methods) for the determination of these drugs. These methods can be used as analytical tools in routine examination in quality control laboratories. Methods: The first method was derivative method in which the first derivative method (1D) for determination of PCM and the second derivative method (2D) for determination of CIN. The second method was the first derivative ratio spectrophotometric method (1DD) for determination of CIN and PCM. Results: In first method, the first derivative spectrum (1D) of PCM where PCM was determined by measuring the amplitude of the valley at 235 nm while CIN showed zero crossing spectrum, and the second derivative spectrum (2D) of CIN where CIN was determined by measuring the amplitude of the peak at 287.5 nm while PCM showed a zero value. In the second method, the first derivative ratio spectrophotometry (1DD) for CIN and PCM determination, where the amplitude at 290 and 291 nm, was selected for the determination of CIN and PCM, respectively. Conclusions: The developed methods were applied for the determination of the cited drugs in tablets containing binary drug mixture. The methods are simple and precise and can be used for routine analysis of the labeled drugs in combined dosage forms in quality control laboratories.

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Development of normalized spectra manipulating spectrophotometric methods for simultaneous determination of Dimenhydrinate and Cinnarizine binary mixture

Cited by 27 publications

References 14 publications

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Validated Spectrophotometric Methods for the Estimation of Cinnarizine in Binary Mixture With Paracetamol in Bulk and Tablets

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