Layperson-Led vs Professional-Led Behavioral Interventions for Weight Loss in Pediatric Obesity

McGavock, Jonathan; Chauhan, Bhupendrasinh F; Rabbani, Rasheda; Dias, Sofia; Klaprat, Nika; Boissoneault, Sara; Lys, Justin; Wierzbowski, Aleksandra; Sakib, Mohammad Nazmus; Zarychanski, Ryan; Abou‐Setta, Ahmed M

doi:10.1001/jamanetworkopen.2020.10364

Cited by 10 publications

(8 citation statements)

References 133 publications

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Section: Conventional Approaches To Behavior Change Are Ineffective F...mentioning

confidence: 99%

“…Changing behaviors among adolescents at risk for or living with T2D is challenging, and the optimal approach for increasing PA among adolescents with T2D remains uncertain. Recent systematic reviews 183–185 suggest that the efficacy of conventional behavioral lifestyle interventions for adolescents living with obesity is modest and rarely sustained. The modest effects may be related to the observation that ~80% of the RCTs of behavioral lifestyle interventions offered only 30 min of support weekly, and only 2 of 35 interventions addressed psychosocial factors 186,187 .…”

Section: Type 2 Diabetes and Exercisementioning

confidence: 99%

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ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes

et al. 2022

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Section: Conventional Approaches To Behavior Change Are Ineffective F...mentioning

confidence: 99%

Section: Type 2 Diabetes and Exercisementioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes

et al. 2022

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“…The comparative safety and efficacy of any two treatment regimens were modeled for each treatment agent relative to the reference treatment agent. We conducted random effects and fixed effects models to pool the network results and selected the preferred model by comparing the deviance information criteria (DIC) ( McGavock et al, 2020 , Spiegelhalter; et al, 2002 ). The models were based on 30,000 iterations after a burn-in of 10,000 iterations.…”

Section: Methodsmentioning

confidence: 99%

Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis

Wang¹,

Wen²,

He³

et al. 2022

International Journal of Infectious Diseases

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“…A consistency model was established to combine direct and indirect comparisons. Random- and fixed-effects models were used to pool the network results and the preferred model by comparing the deviance information criteria (DIC) (Spiegelhalter et al, 2002 ; McGavock et al, 2020 ). The comparative efficacy and safety of any two treatment regimens was modeled such that each drug was relative to the other, and the point estimates [relative risks (RRs), or mean differences (MDs)] and the relevant 95% credible intervals (CrIs) were then obtained from the model.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological Treatment in the Management of Chronic Subdural Hematoma

Wang

Song

et al. 2021

Front. Aging Neurosci.

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Background: Several pharmacological treatments have been used to treat patients with chronic subdural hematoma (CSDH), although little is known about the comparative effectiveness of different classes of medication. We performed a Bayesian network meta-analysis to compare and rank the efficacy and safety of five drug regimens to determine the best treatment for this group of patients.Methods: We systematically searched PubMed, Medline, clinicaltrials.gov, the Cochrane database, and Embase to identify relevant randomized clinical trials (RCTs) comparing drug treatments in adult patients with CSDH. A network meta-analysis was conducted using a Bayesian framework. Random- and fixed-effects models were used to pool the network results, and the preferred model was selected by comparing the deviance information criteria (DIC). Efficacy outcomes included recurrence requiring surgery, changes in hematoma volume, and a good recovery. The safety outcomes were treatment-related adverse events and all-cause mortality.Results: In this Bayesian network meta-analysis, available data were obtained from 12 eligible trials, including 2,098 patients and 5 techniques. Compared to placebo, atorvastatin (RR: 0.45, 95% CrI: 0.24–0.81) and dexamethasone (RR: 0.38, 95% CrI: 0.22–0.63) were similarly effective in reducing recurrence requiring surgery by 55% and 62%, respectively. Dexamethasone (RR: 0.46, 95% CrI: 0.23–0.91) was more effective in reducing recurrence requiring surgery than goreisan. Additionally, atorvastatin reduced the hematoma volume to a greater extent than placebo (MD: −7.44, 95% CrI: −9.49 to −5.43) or goreisan (MD: −14.09, 95% CrI: −23.35 to −4.82). Moreover, tranexamic acid (MD: −12.07, 95% CrI: −21.68 to −2.29) reduced the hematoma volume to a greater extent than goreisan. No significant differences were detected between drugs and placebo with regard to a good recovery. In terms of safety, dexamethasone (RR: 1.96, 95% CrI: 1.20–3.28) increased the risk of mortality compared to placebo.Conclusion: These findings suggest that dexamethasone is the best treatment to reduce recurrence and atorvastatin is the best treatment to reduce hematoma volume in patients with CSDH. However, clinicians should pay close attention to the elevated risk of all-cause mortality and potential adverse events caused by dexamethasone. Future well-designed RCTs with more participants are needed to verify these findings.Clinical Trial Registration:http://osf.io/u9hqp.

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Layperson-Led vs Professional-Led Behavioral Interventions for Weight Loss in Pediatric Obesity

Abstract: This systematic review and meta-analysis investigates the association of professional-led and layperson-led weight loss interventions with short- and long-term weight reduction among children and adolescents with overweight and obesity.

Cited by 10 publications

References 133 publications

ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes

ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes

Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis

Pharmacological Treatment in the Management of Chronic Subdural Hematoma

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