Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis

COVID-19 and metabolic syndrome

“…Dexamethasone improves outcomes in COVID-19 [63] . However, it raises blood glucose by increasing insulin resistance.…”

Corticosteroids in COVID-19: pros and cons

“…However, the key practical limitation is the lack of large blinded randomized control trials for anti-viral agents (4,19). A number of large trials have shifted the paradigm of the treatment of COVID-19 and recently published systematic reviews/meta-analyses have highlighted the widespread use of corticosteroids, most notably dexamethasone (59,(79)(80)(81), as highlighted in Table 1. These reviews have portrayed the potential of these agents to decrease mortality in hypoxemic patients patients requiring oxygen supplementation (59,(79)(80)(81).…”

“…A number of large trials have shifted the paradigm of the treatment of COVID-19 and recently published systematic reviews/meta-analyses have highlighted the widespread use of corticosteroids, most notably dexamethasone (59,(79)(80)(81), as highlighted in Table 1. These reviews have portrayed the potential of these agents to decrease mortality in hypoxemic patients patients requiring oxygen supplementation (59,(79)(80)(81). The same benefit has not been observed in patients with mild COVID-19 symptoms (59,(79)(80)(81).…”

“…These reviews have portrayed the potential of these agents to decrease mortality in hypoxemic patients patients requiring oxygen supplementation (59,(79)(80)(81). The same benefit has not been observed in patients with mild COVID-19 symptoms (59,(79)(80)(81). A notable example of such investigations is the RECOVERY trial (18).…”