Layered double hydroxides as effective carrier for anticancer drugs and tailoring of release rate through interlayer anions

Senapati, Sudipta; Thakur, Ravi; Verma, Swati; Duggal, Shivali; Mishra, Durga Prasad; Das, Parimal; Shripathi, T.; Kumar, Manoj; Rana, Dipak; Maiti, Pralay

doi:10.1016/j.jconrel.2016.01.016

Cited by 129 publications

(75 citation statements)

References 50 publications

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“…The final decomposition products were those obtained by the crystallization of MgO, MgAl 2 O 4 and Al 2 O 3 at a temperature of 550°C. 39 …”

Section: Tgmentioning

confidence: 99%

Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery

Xu¹,

Xu²,

Gu³

et al. 2018

IJN

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Background To enhance ocular bioavailability, the traditional strategies have focused on prolonging precorneal retention and improving corneal permeability by nano-carriers with positive charge, thiolated polymer, absorption enhancer and so on. Glycylsarcosine (GS) as an active target ligand of the peptide tranpsporter-1 (PepT-1), could specific interact with the PepT-1 on the cornea and guide the nanoparticles to the treating site. Purpose The objective of the study was to explore the active targeting intercalated nanocomposites based on chitosan-glutathione-glycylsarcosine (CG-GS) and layered double hydroxides (LDH) as novel carriers for the treatment of mid-posterior diseases. Materials and methods CG-GS-LDH intercalated nanocomposites were prepared by the coprecipitation hydrothermal method. In vivo precorneal retention study, ex vivo fluorescence images, in vivo experiment for distribution and irritation were studied in rabbits. The cytotoxicity and cellular uptake were studied in human corneal epithelial primary cells (HCEpiC). Results CG-GS-LDH nanocomposites were prepared successfully and characterized by FTIR and XRD. Experiments with rabbits showed longer precorneal retention and higher distribution of fluorescence probe/model drug. In vitro cytological study, CG-GS-LDH nanocomposites exhibited enhanced cellular uptake compared to pure drug solution. Furthermore, the investigation of cellular uptake mechanisms demonstrated that both the active transport by PepT-1 and clathrin-mediated endocytosis were involved in the internalization of CG-GS-LDH intercalated nanocomposites. An ocular irritation study and a cytotoxicity test indicated that these nanocomposites produced no significant irritant effects. Conclusions The active targeting intercalated nanocomposites could have great potential for topical ocular drug delivery due to the capacity for prolonging the retention on the ocular surface, enhancing the drug permeability through the cornea, and efficiently delivering the drug to the targeted site.

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“…The final decomposition products were those obtained by the crystallization of MgO, MgAl 2 O 4 and Al 2 O 3 at a temperature of 550°C. 39 …”

Section: Tgmentioning

confidence: 99%

Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery

Xu¹,

Xu²,

Gu³

et al. 2018

IJN

View full text Add to dashboard Cite

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“…The cells were cultured at 37 °C using a CO 2 incubator humidified with 5% CO 2 . Cytotoxicity evaluation of GO, GN, and GS was performed using MTT assay as described according to our previous study . Approximately, 1 × 10 5 mL −1 cells (NIH‐3T3 and HeLa) were seeded in a 96‐well plate and were incubated for 24 h at 37 °C in a CO 2 incubator with 5% CO 2 supply.…”

Section: Methodsmentioning

confidence: 99%

Fluorescent‐functionalized graphene oxide for selective labeling of tumor cells

Senapati

Patel

Ray

et al. 2019

J Biomedical Materials Res

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Fluorescence probe has attracted significant attention for biomedical imaging in recent years due to their high resolution at the cellular level. Organic‐based fluorescent probes with high quantum yield are widely applied in bioimaging, but most of them suffer from a serious obstacle called aggregation‐caused quenching in cellular systems. New fluorophore has been designed through functionalization of graphene oxide which emphatically exhibits aggregation‐induced emission along with pH‐responsive nanoprobe. Significantly higher emission of this material in slightly acidic media helps to detect tumor cell by creating a sharp contrast with the image of normal cells. The reason for pH‐induced enhanced emission phenomenon is revealed through aggregation of sulfonated species in acidic media. Furthermore, the biocompatible nature of the newly developed material is found to be suitable for its application in biomedical imaging for cancer detection with better accuracy at lower cost. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1917–1924, 2019.

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“…The pure drug and the fast release system LP‐R resulted in bile ductular proliferation and congested portal vein in the portal triad in liver tissues (indicated by red arrows) and cloudy degeneration of the tubular epithelial cells in the kidney (indicated by blue arrows). Reproduced with permission . Copyright 2016, Elsevier.…”

Section: Biosafety Evaluationmentioning

confidence: 99%

“…Moreover, while intravenously treated by Cu substituted Mg‐LDH, all mice showed negligible weight changes and none organ injuries were observed from H&E staining images . Senapati et al investigated the effect of type of interlayer anions on in vivo toxicity of LDH nanoparticles by synthesizing raloxifene hydrochloride‐intercalated LDH with interlayer nitrate, carbonate, or phosphate anions (designated as LN‐R, LC‐R, and LP‐R, respectively) . They found that LN‐R exhibited greater interactions with the drug and sustained drug delivery compared to the loosely interacted LP‐R showing fast drug release .…”

Section: Biosafety Evaluationmentioning

confidence: 99%

“…Senapati et al investigated the effect of type of interlayer anions on in vivo toxicity of LDH nanoparticles by synthesizing raloxifene hydrochloride‐intercalated LDH with interlayer nitrate, carbonate, or phosphate anions (designated as LN‐R, LC‐R, and LP‐R, respectively) . They found that LN‐R exhibited greater interactions with the drug and sustained drug delivery compared to the loosely interacted LP‐R showing fast drug release . The fast release system (LR‐R) demonstrated obvious side effects in a breast cancer xenograft mouse model in terms of decreased body weight and damage to liver and kidney, which was not the case in the slow release system (LN‐R) …”

Section: Biosafety Evaluationmentioning

confidence: 99%

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2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

et al. 2019

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2D nanomaterials represent one of the next‐generation biomaterials with versatile physicochemical advantages that allow for diverse biomedical applications in disease diagnosis, prevention, and treatment. In particular, layered double hydroxide (LDH) nanoparticles, as a typical 2D nanomaterial, have recently shown unprecedented advances in controllable and simplified chemical construction, versatile surface engineering, and comprehensive biological investigation. To realize in vivo biomedical applications, recent efforts have been substantially devoted to a few critical aspects of LDH nanomedicine including nanoparticle stability in physiological environments, accumulation at the disease‐targeted site, selective biological response to the nanoparticle, systematic biosafety examination, integration with multiple diagnostic and therapeutic modalities, and the adjuvant activity and suitability for gene‐based and protein‐based vaccines, which are herein comprehensively reviewed. The challenges and future development strategies of LDH nanomedicine are also discussed toward practical biomedical applications to benefit patients.

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Layered double hydroxides as effective carrier for anticancer drugs and tailoring of release rate through interlayer anions

Cited by 129 publications

References 50 publications

Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery

Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery

Fluorescent‐functionalized graphene oxide for selective labeling of tumor cells

2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

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