Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Abstract

Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state‐of‐the‐art achievements are summarized for the first time. The potential of LDHs‐based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs‐based scaffold design are proposed for facilitated clinical translation.

Recent advances using MXenes in biomedical applications

“…Environmentally-responsive 2D materials with a broad range of biomedical applications have been developed in previous studies. 17–21 For example, Shen and co-workers have shown that cobalt-molybdenum-based 2D layered double hydroxide (LDH) nanosheets (CoMo-LDH) can be used for photo-responsive dynamic therapy for cancer treatment. The CoMo-LDH nanosheets contain, by design, defects in the structure that enhance their photocatalytic and electrocatalytic activities.…”

Coordination-induced and tunable layered rare-earth hydroxide-complex intercalated nanohybrid phosphorescent photosensitizer and therapy

“…5,6 Among the myriad of matrixes, layered double hydroxides (LDHs, hydrotalcites) are widely selected as a two-dimensional host matrix to construct multicolor host-guest luminescent materials. [7][8][9] Hydrotalcites possesses the following advantages:…”

Highly Crystalline Copper Aluminum-Layered Double Hydroxides with Intrinsic Fenton-Like Catalytic Activity for Robust Oral Health Management

“…Layered double hydroxides (LDHs) are a new type of inorganic functional materials in which hydroxyl groups can coordinate with both divalent and trivalent metal cations . By virtue of their versatility in chemical composition and structure, good biocompatibility, and highly tunable distance between host layers, LDHs have gained widespread attention in vaccine preparation, bioimaging, tissue repair, and the treatments of infection, bone disease, and cancer. − Notably, the interlayer spacing and specific surface area of LDHs can be altered on purpose toward the storage of chemicals, drugs, or biomolecules, promising their ideal role in the delivery of guest molecules. − Moreover, LDHs and their composites with different morphologies and charges can be prepared by regulating the raw materials . Given their admirable performances, we envision that the combination of noniron valence-variable metals into LDHs may trigger Fenton-like reactions and achieve high antibacterial efficacy.…”