Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate

Chakraborty, Manjusha; Dasgupta, Sudip; Bose, Poulomi; Misra, Akhilesh Kumar; Mandal, Tapan Kumar; Mitra, M.K.; Chakraborty, Jayanta; Basu, Debabrata

doi:10.1016/j.jpcs.2011.03.012

Cited by 29 publications

(19 citation statements)

References 23 publications

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“…53 Regarding the low wavenumber region of the spectrum (400-800 cm −1 ), it is expected that bands correspond to metal-oxygen and metalhydroxyl vibration modes in the LDH sheets. [54][55][56] These bands confirm the Zn-Al LDH structure. 57 In the spectrum of the ZnAl-CD LDH nanohybrid ( Figure 3B), the characteristic peak associated with the parent LDH-like hydroxide group, which also arises from the phenolic hydroxides, appears at 3,390.4 cm −1 , which, together with the emergence of bands below 1,000 cm −1 , indicates that the layers structure of LDH has not changed during the intercalation process.…”

Section: Physicochemical Characterization Of Cd-ldh Nanohybrid Xrdsupporting

confidence: 59%

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Khan¹,

Alamry²,

Alyahyawi³

et al. 2018

IJN

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BackgroundThe intercalation of an antibiotic drug, cefadroxil (CD), into the inter-gallery of Zn, Al nitrate-layered double hydroxide (LDH) was accomplished using a co-precipitation method. This formed a nanostructured organic–inorganic hybrid material that can be exploited for the preparation of a controlled release formulation.Materials and methodsThe drug–LDH nanohybrid was characterized by using field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) thermogravimetric (TG) analysis, X-ray powder diffraction (XRD) and UV–visible (UV–vis) absorption spectroscopy, which confirmed the intercalation process. Release tests of nanohybrid in the presence or absence of NaCl or poly-acrylamide (PAM) were performed in vitro in gastric (pH 1.2), lysosomal (pH 4.0), intestinal (pH 6.8) and blood (pH 7.4) simulated fluid using UV–vis spectroscopy.ResultsAt pH 1.2, LDH was dissolved and intercalated antibiotic released from ZnAl-CD in a molecular form, which led to a significant increase in the antibiotic’s solubility. Results showed that the release of drug from nanohybrid at pH 4.0, 6.8 and 7.4 was a sustained process.ConclusionThis material might reduce side effects by the release of the drug in a controlled manner. However, it was found that the presence of Cl or PAM species in the release media has a negative impact on the release behavior. The weathering mechanism is responsible for the release of CD from the nanocomposite at pH 1.2, while the mechanism of anion exchange may be responsible for the release behavior at pH 4.0, 6.8 and 7.4. A number of kinetic models were chosen to gain more insights into the mechanisms of drug release. At pH 1.2, the zero-order model most satisfactorily explained the release kinetics of CD, while the release data of CD at pH 4.0, 6.8 and 7.4 were governed by Bhaskar kinetics.

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Section: Physicochemical Characterization Of Cd-ldh Nanohybrid Xrdsupporting

confidence: 59%

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Khan¹,

Alamry²,

Alyahyawi³

et al. 2018

IJN

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“…The same is reported in the literature also . It corresponds to a gallery height of 2.75 Å in pristine LDH with carbonate ions as the main species in the interlayer where the brucite like LDH main layer have a thickness of 4.8 Å, but when under intense ultra‐sonication LDH interlayer is intercalated by acrylamide monomers the basal spacing shifts from 7.55 Å to 7.65 Å. Further, under intense ultra‐sonication and assisted by the presence of catalyst and polymerization initiator the acrylamide in the interlayer positions undergo further polymerization as a result the basal spacing shifts further.…”

Section: Resultsmentioning

confidence: 99%

Prospects use of hybrid layered double hydroxides‐polyacrylamide as controlled release media for antibiotic molecules

Allou

Bordoloi

Goswamee

2017

J of Applied Polymer Sci

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Some controlled‐release media containing two commercial antibiotic molecules, viz. Amoxicillin (AMX) and Ampicillin (AMP), were prepared using layered double hydroxides (LDH) intercalated and extended by polyacrylamide. The polycarylamide was prepared in situ by polymerization of acrylamide monomer intercalated in the interlayers of LDH. The LDH‐polyacrylamide‐antibiotic hybrid nanocomposites were characterized by various techniques like Fourier transform infrared (FT‐IR), powder X‐ray diffraction (XRD), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FE‐SEM). The results from these characterizations have shown the successful incorporation of the antibiotics in the interlayers and provided important information regarding their interlayer structure. The nanocomposites showed increased thermal stability in TGA. The loading of antibiotic in the PAM/Mg‐Al nanocomposite was found to be 36.33% for AMX and 52.38% for AMP. The improved antibacterial activity of hybrid nanocomposite was evaluated against Escherichia coli using the wells diffusion technique. The aliquot samples in agar media drug release study were found to be highly effective against microorganisms. The sustained release of antibiotic drug from the hybrid nanocomposite was also verified. The release rate at pH 7.4 phosphate buffer was found slower than that at pH 4.6. It can be concluded that hybrid nanocomposites of LDH extended by in situ polymerized acrylamide are very suitable materials to host different antibiotics and their controlled release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45442.

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“…Riaz and Ashaf [ 85 ] have given a short review of recent research into the intercalation and delivery of anti-cancer drugs using LDHs. To date, LDHs have been utilized as nanocarriers for many anti-cancer drugs, such as folinic acid [ 48 ], methotrexate [ 48 , 50 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ], 5-flourouracil [ 94 , 95 , 96 , 97 ] and doxifluridine [ 17 ], comptothecin [ 98 , 99 , 100 ], K 7 [PTiW 10 O 40 ]·6H 2 O [ 101 ], podophyllotoxin [ 102 ], and doxorubicin [ 103 ].…”

Section: Drug–ldh Ddsmentioning

confidence: 99%

“…In the meantime, Chakraborty and Ghosh [ 88 , 89 , 90 , 91 , 92 ] also prepared MTX–LDH by different methods and studied the particle dissolution and subsequent drug release properties from the matrix in PBS solution. A striking enhancement in efficacy/sensitivity of MTX against HCT-116 cells was obtained when intercalated within the LDH host, as revealed by the attainment of the half maximal inhibitory concentration of MTX–LDH nanohybrid after only 48 h, whereas bare MTX required 72 h to achieve the same effect.…”

Section: Drug–ldh Ddsmentioning

confidence: 99%

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

2014

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Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.

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Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate

Cited by 29 publications

References 23 publications

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Prospects use of hybrid layered double hydroxides‐polyacrylamide as controlled release media for antibiotic molecules

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

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Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate

Cited by 29 publications

References 23 publications

Controlled release of organic&ndash;inorganic nanohybrid:cefadroxil intercalated Zn&ndash;Al-layered double hydroxide

Controlled release of organic&ndash;inorganic nanohybrid:cefadroxil intercalated Zn&ndash;Al-layered double hydroxide

Prospects use of hybrid layered double hydroxides‐polyacrylamide as controlled release media for antibiotic molecules

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

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Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide