Layered Double Hydroxide-Based Nanocarriers for  Drug Delivery

Bi, Xue; Zhang, Hui; Dou, Liguang

doi:10.3390/pharmaceutics6020298

Cited by 187 publications

(112 citation statements)

References 123 publications

(222 reference statements)

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“…For example, LDHs were used as additives in polymers [9], as adsorbents for water remediation [18], as precursors for functional materials, applied in the synthesis of pharmaceuticals [19], in photochemistry [20] and electrochemistry [21]. Moreover, LDHs prepared directly and their calcined mixed metal oxide (MMOs) products have been widely used as an actual solid base catalyst, and promising precursors or supports of catalysts in a variety of fields including organic synthesis, adsorption of organic wastes or heavy metals ions, and the decomposition of volatile organic compounds [22].…”

Section: Ldh-based Composite Materialsmentioning

confidence: 99%

Polyoxometalate (POM)-Layered Double Hydroxides (LDH) Composite Materials: Design and Catalytic Applications

Miras

Song

2017

Catalysts

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Layered double hydroxides (LDHs) are an important large class of two-dimensional (2D) anionic lamellar materials that possess flexible modular structure, facile exchangeability of inter-lamellar guest anions and uniform distribution of metal cations in the layer. Owing to the modular accessible gallery and unique inter-lamellar chemical environment, polyoxometalates (POMs) intercalated with LDHs has shown a vast array of physical properties with applications in environment, energy, catalysis, etc. Here we describe how polyoxometalate clusters can be used as building components for the construction of systems with important catalytic properties. This review article mainly focuses on the discussion of new synthetic approaches developed recently that allow the incorporation of the element of design in the construction of a fundamentally new class of materials with pre-defined functionalities in catalytic applications. Introducing the element of design and taking control over the finally observed functionality we demonstrate the unique opportunity for engineering materials with modular properties for specific catalytic applications.Keywords: layered double hydroxides; polyoxometalates; intercalated materials Layered Double Hydroxides (LDHs)-Intro BackgroundLayered double hydroxides (LDHs) or hydrotalcite-like compounds are a large family of two-dimensional (2D) anionic clay materials made up of positively charged brucite-like layers with an interlayer region containing charge compensating anions and solvation molecules, which can be represented by the general formula -4]. As shown in Figure 1 and generally in the range of 0.20-0.33, which occupy the space between the layers compensating for the positive charge and inducing stability in the overall structure [5,6]. The M II /M III -based edge shared octahedra are used to construct 2D infinite sheets, whereas hydroxyl groups are organized on the vertices of the octahedra with the hydrogen atoms pointing toward the interlayer region, as a consequence forming a complex network of hydrogen bonds with the interlayer anions and water molecules [1,[7][8][9][10]. LDH-based materials are very attractive systems due to their robust structure,

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Section: Ldh-based Composite Materialsmentioning

confidence: 99%

Polyoxometalate (POM)-Layered Double Hydroxides (LDH) Composite Materials: Design and Catalytic Applications

Miras

Song

2017

Catalysts

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“…Anions may be small, e.g., CO , or large such as methotrexate, 5-fluoruracil, and ibuprofen [4][5][6]. [7]. The x mole fraction of the trivalent cation is normally between 0.2 and 0.4 [8].…”

Section: Layered Double Hydroxidesmentioning

confidence: 99%

Functionalization of Surfaces in Layered Double Hydroxides and Hydroxide Salt Nanoparticles

Arízaga¹,

Jiménez²,

Viruete³

et al. 2016

Functionalized Nanomaterials

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Layered double hydroxides (LDH) and layered hydroxide salts (LHS) are widely studied as matrices to design new materials with applications in several areas of science and technology. Both LDH and LHS are composed of molecular layered units with surfaces fully covered by hydroxyl groups and positive-charge residues within the layers; therefore, anions in the interlayer space are needed. Even though these anions are described as interlayer species without a covalent interaction with the molecular layered units, the substitution of hydroxyl groups is also possible; in other words, the functionalization of the surface could occur. This chapter reviews results previously published related to the functionalization phenomenon in LDH and LHS, which is not considered in most of the scientific reports of new materials derived from these compounds. In this text, the use of copper probes to study electron paramagnetic resonance spectra, reinforced with infrared spectroscopy to confirm functionalization, is described. The occurrence of functionalization instead of a simple anion exchange provides a change of properties in the final nanosized material.

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“…[2,3] LDHs, also known as anionic clays, are found in Nature and many of their representatives belong to the hydrotalcite supergroup. For use, they are mostly synthesised.…”

Section: Introductionmentioning

confidence: 99%

“…These anions can be exchanged to more complex organic anions forming organic-inorganic functional nanocomposites having technological importance in catalysis, [6] nanocomposite materials engineering, [7] medical and pharmaceutical sciences. [3] A number of cardiovascular or anti-inflammatory agents, either carboxylic acids or carboxylic derivates could be ion-exchanged with LDHs to have controlled release. [8][9][10][11] Other drugs have already been introduced between the hydroxide layers [3,12,13] as well.…”

Section: Introductionmentioning

confidence: 99%

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Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides

et al. 2015

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Layered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the uptake of the loaded drug in the cells. In our previous studies, Mössbauer spectroscopy was applied to monitor structural changes occurring during the incorporation of Fe(III) in MgFe-and CaFe-LDHs, and the intercalation of various organic compounds in anionic form. Recently, we have successfully elaborated a protocol for the intercalation and release of indol-2-carboxylate and L-cysteinate in CaFe-LDH. The corresponding structural changes in the LDH samples were studied by XRD, HR-TEM and 57 Fe Mössbauer spectroscopy. The Mössbauer spectra reflected small but significant changes upon both the intercalation and the release of drugs. The changes in the basal distances could be followed by XRD measurements, and HR-TEM images made these changes visible.

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Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

Cited by 187 publications

References 123 publications

Polyoxometalate (POM)-Layered Double Hydroxides (LDH) Composite Materials: Design and Catalytic Applications

Polyoxometalate (POM)-Layered Double Hydroxides (LDH) Composite Materials: Design and Catalytic Applications

Functionalization of Surfaces in Layered Double Hydroxides and Hydroxide Salt Nanoparticles

Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides

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