Layer-by-layer polyelectrolyte coating of low molecular weight poly(lactic acid) nanoparticles

Hirsjärvi, Samuli; Peltonen, Leena; Hirvonen, Jouni

doi:10.1016/j.colsurfb.2006.03.009

Cited by 42 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Originally the technique was applied to flat surfaces, [66] but it has since also been used to coat polymeric drug nanoparticles. [67] The principle of the LbL coating is electrostatic adsorption of the polyelectrolytes on charged surfaces. The highly charged polymeric layer that is formed on the drug particle surface prevents particle aggregation.…”

Section: Stabilizers Used In Nanomillingmentioning

confidence: 99%

“…Sequential electrostatic LbL adsorption of oppositely charged polyelectrolytes on a charged surface forms ultrathin coating layers with tailored properties. Originally the technique was applied to flat surfaces, [66] but it has since also been used to coat polymeric drug nanoparticles [67] . The principle of the LbL coating is electrostatic adsorption of the polyelectrolytes on charged surfaces.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

Peltonen

Hirvonen

2010

Journal of Pharmacy and Pharmacology

Self Cite

310

194

View full text Add to dashboard Cite

Objectives Wet milling is a common technique to produce drug nanocrystals. Stability of the nanocrystals is a critical question, and different kinds of stabilizers, e.g. polymers, celluloses, surfactants and lipids, have been tested for various drugs. Still, the question about how to select the best stabilizer to a certain drug material and also to a selected process is open. Key findings Many different factors, such as surface energy, hydrophobicity, solubility, viscosity and functional groups, affect the stability of the formed nanosuspensions. Affinity of the stabilizer to the particle surfaces seems to be the most important parameter. This affinity is partly related to the surface energy and hydrophobicity of the surfaces and stabilizers. Summary In this review the most important factors affecting nanocrystal formulation and efficacy of stabilizers are presented. In order to widen understanding of the milling process, the most important variables related to milling techniques and particle fracturing processes during the milling are briefly presented.

show abstract

Section: Stabilizers Used In Nanomillingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

Peltonen

Hirvonen

2010

Journal of Pharmacy and Pharmacology

Self Cite

310

194

View full text Add to dashboard Cite

show abstract

“…Furthermore, faster release of DOX was also observed for the DOXloaded micelles with high density of cross-links (70%), which may have more peripheral drug localization and hence faster release [36]. In another study, layer by layer (LbL) coating technique which produces nanoparticle drug delivery systems with improved biocompatibility and sustained or targeted release of drug was used based on sequential electrostatic layer-bylayer (LbL) adsorption of oppositely charged polyelectrolytes (PEs) on a charged substrate produces ultra-thin PE multilayers with controlled properties [37].…”

Section: Effect Of Zp On Controlled Drug Releasementioning

confidence: 99%

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

Honary¹,

Zahir²

2013

Trop. J. Pharm Res

464

503

View full text Add to dashboard Cite

show abstract

“…Tangential flow filtration (TFF), or cross-flow filtration, has been found as a very practical method to purify nanoparticulate dispersions from these impurities (5,13,(17)(18)(19)(20). It is a more gentle and continuous process and more easily scaled up than, e.g., the traditional dead-end ultrafiltration (21) or ultracentrifugation (22). In TFF, the dispersion is pumped tangentially along the surface of the membrane.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sugars, Surfactant, and Tangential Flow Filtration on the Freeze-Drying of Poly(lactic acid) Nanoparticles

2009

Self Cite

View full text Add to dashboard Cite

Abstract. Poly(D,L-lactic acid) nanoparticles were freeze-dried in this study. With respect to drying, effect of protective excipients and purification from excess surfactant were evaluated. The nanoparticles were prepared by the nanoprecipitation method with or without a surfactant, poloxamer 188. The particles with the surfactant were used as such or purified by tangential flow filtration. The protective excipients tested were trehalose, sucrose, lactose, glucose, poloxamer 188, and some of their combinations. The best freeze-drying results in terms of nanoparticle survival were achieved with trehalose or sucrose at concentrations 5% and 2% and, on the other hand, with a combination of lactose and glucose. Purification of the nanoparticle dispersion from the excess surfactant prior to the freeze-drying by tangential flow filtration ensured better drying outcome and enabled reduction of the amount of the protective excipients used in the process. The excess surfactant, if not removed, was assumed to interact with the protective excipients decreasing their protective mechanism towards the nanoparticles.

show abstract

Layer-by-layer polyelectrolyte coating of low molecular weight poly(lactic acid) nanoparticles

Cited by 42 publications

References 26 publications

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

Effect of Sugars, Surfactant, and Tangential Flow Filtration on the Freeze-Drying of Poly(lactic acid) Nanoparticles

Contact Info

Product

Resources

About