Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

Honary, S; Zahir, F

doi:10.4314/tjpr.v12i2.20

Cited by 495 publications

(603 citation statements)

References 29 publications

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“…Nanoparticles of this size not only can be internalized by endocytosis but also are large enough to be maintained in circulation for a long period (Anselmo & Mitragotri, 2016). More negative (À) or positive (+) electricity prevented the particles from aggregation due to the repelling interaction (Honary & Zahir, 2013;Gossmann et al, 2015). Zeta potential values of drug-loaded NPs and unloaded ones were À23.45 ± 1.54 and À22.73 ± 1.63 mV, respectively, indicating the stability of NUC-PLGA-NPs in suspension.…”

Section: Size and Zeta Potentialmentioning

confidence: 99%

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

Liu¹,

Wu²,

Mi³

et al. 2017

Drug Delivery

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This article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid accumulation. NUC-loaded poly lactic-co-glycolic acid nanoparticles (NUC-PLGANPs) were prepared according to a solid/oil/water (s/o/w) emulsion technique due to the waterinsolubility of NUC. PLGA exhibited excellent loading capacity for NUC with adjustable dosing ratios. The drug loading and encapsulation efficiency of optimized formulation were 8.89 ± 0.71 and 88.54 ± 7.08%, respectively. NUC-PLGA-NPs exhibited a spherical morphology with average size of 150.83 ± 5.72 nm and negative charge of À22.73 ± 1.63 mV, which are suitable for oral administration. A sustained NUC released from NUC-PLGA-NPs with an initial exponential release owing to the surface associated drug followed by a slower release of NUC, which was entrapped in the core. In addition, $77 ± 6.67% was released in simulating intestinal juice, while only about 45.95 ± 5.2% in simulating gastric juice. NUC-PLGA-NPs are more efficient against oleic acid (OA)-induced hepatic steatosis in HepG 2 cells when compared to naked NUC (n-NUC, *p50.05). The oral bioavailability of NUC-PLGA-NPs group was significantly higher (**p50.01) and a significantly decreased serum levels of total cholesterol (TC), triglycerides (TG) and lowdensity lipoprotein cholesterol (LDL-C), as well as a higher concentration of high-density lipoprotein cholesterol (HDL-C) was observed, compared with that of n-NUC treated group. These findings suggest that NUC-PLGA-NPs hold great promise for sustained and controlled drug delivery with improved bioavailability to alleviating lipogenesis.

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Section: Size and Zeta Potentialmentioning

confidence: 99%

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

Liu¹,

Wu²,

Mi³

et al. 2017

Drug Delivery

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“…As a nonionic surfactant, Tween 80 can maintain the stability of the single layer nanoemulsion. As a standard, zeta potential values above±30 mV indicate good stability in a nanoemulsion [14]. The zeta potential value obtained for the nanoemulsion gel was −27.1 mV.…”

Section: Discussionmentioning

confidence: 98%

Physical Stability and Antioxidant Activity Assay of a Nanoemulsion Gel Formulation Containing Tocotrienol

Suminar

Jufri

2017

Int J App Pharm

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Objective: Tocotrienols have an antioxidant potential higher than that of tocopherols. Nanoemulsion gel can deliver tocotrienols into the skin to prevent skin damage caused by free radicals and improve the stability of the dosage form. The present study aimed to determine the physical stability and antioxidant activity of a nanoemulsion gel formulation containing tocotrienol. Methods:The tocotrienol nanoemulsion was made using tocotrienols, oleic acid, Tween 80, 96% ethanol, and propylene glycol. The gel base was made using a carbomer and triethanolamine. A physical stability test was conducted at three different temperatures, namely, low temperature (4±2°C), room temperature (27±2°C), and high temperature (40±2°C). The antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl method for determining inhibitory concentration (IC 50 ) values.Results: Formula 1 demonstrated the best physical stability, with a pH of 6.2. The droplet size of the tocotrienol nanoemulsion gel was 596 nm, with a zeta potential value of −27.1 nm. The IC 50 of the tocotrienol nanoemulsion gel was 6252.14 ppm. Conclusion:The nanoemulsion gel formulation retained antioxidant activity and was physically stable for 8 weeks.

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“…Furthermore, zeta potential is an important feature in relation to the interaction of nanoparticles with cell membranes which is influenced by the surface charge of the nanoparticles [55]. The overall surface charge of cancer cells is normally negative [53] and positively charged nanoparticles strongly bind to the negatively charged cell membrane. Furthermore, positive nanoparticles have a much greater cytotoxicity compared to neutral nanoparticles due to being more efficient at penetrating and crossing the cell membrane of the cancer cell through endocytosis [55][56][57].…”

Section: Plga Nanoparticlesmentioning

confidence: 99%

“…When the surface charge is high there is a strong electrostatic repulsion between the nanoparticles, which results in reduced aggregation [53][54]. The minimum zeta potential required for stability is ±30 mV and all of the nanoparticles were positively charged with a zeta potential range of +35.2 to +57.5mV (Table 2).…”

Section: Plga Nanoparticlesmentioning

confidence: 99%

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

Najlah

Ahmed

Iqbal

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer in both men and women. A recent phase IIb study demonstrated that disulfiram (DSF) in combination with cisplatin and vinorelbine was well tolerated and prolonged the survival of patients with newly diagnosed NSCLC. However, DSF is rapidly (4 minutes) metabolised in the bloodstream and it is this issue which is limiting its anticancer application in the clinic. We have recently demonstrated that a low dose of DSF-loaded PLGA nanoparticles supplemented with oral Cu inhibited tumour growth and reduced metastasis in a xenograft mouse lung cancer model. Here we demonstrate the influence of PLGA polymer, stabilizer loading and molecular weight as well as sonication time on the characteristics, including DSF release and the cytotoxicity of 10% w/w DSF-loaded PLGA nanoparticles. The paper demonstrates that the choice of PLGA as no significant influence on the characteristics of the nanoparticles apart from their DSF release, which is due to the differing degradation rates of the polymers. However, increasing the loading and molecular weight of the stabilizer as well as the sonication time reduced the size of the nanoparticles, reduced their ability to protect the DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity. Additionally, increasing the sonication time resulted in the premature degradation of the PLGA, which increased the permeability of the nanoparticles further decreasing their ability to protect DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity.

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Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

Abstract: The zeta potential (ZP)

Cited by 495 publications

References 29 publications

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

Physical Stability and Antioxidant Activity Assay of a Nanoemulsion Gel Formulation Containing Tocotrienol

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

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