Layer-by-Layer Deposition of Polymeric Microgel Films on Surgical Sutures for Loading and Release of Ibuprofen

Abstract

Surgical sutures capable of drug loading and sustained release are important in wound healing applications. In this work, a facile way to incorporate anti-inflammatory drug of ibuprofen in surgical sutures has been established. First, surgical sutures were deposited with multilayer films containing microgels of chemically cross-linked poly(allylamine hydrochloride) (PAH) and dextran (named PAH-D) by layer-by-layer deposition of PAH-D and hyaloplasm acid (HA). Ibuprofen was then incorporated in the PAH-D/HA films to obtain ibuprofen-loaded sutures. Ibuprofen incorporated in the surgical sutures can be released in 0.9% normal saline in a sustainable way. The successful incorporation of ibuprofen in surgical sutures depends largely on PAH-D microgels, which can deposit directly on the hydrophobic surgical sutures without any surface modification and load ibuprofen based on electrostatic interaction between them. The present study provides a facile and generally applicable way to incorporate drugs in surgical sutures that is highly useful to accelerate the healing of cuts and wounds.

Suture materials — Current and emerging trends

“…Sustained release of drugs at a specific site can allow therapeutically relevant concentration locally for prolonged duration without exceeding toxic limit in the systemic circulation. Drug‐eluting sutures are developed using various procedures including coating the suture surface by dip method, grafting, or by electrospinning process . The challenge in fabricating a drug‐eluting suture is to obtain the required concentration and potency of the drug without compromising on the much important mechanical properties of the suture and this can be achieved by augmenting polymer degradation and controlled drug release strategies.…”

Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

“…Among the developments, the formation of covalent linkages between adjacent layers has been shown to be an effective method for stabilizing the LbL multilayers, allowing them to be used in biologically relevant environments over prolonged periods. [11][12][13] In particular, a number of drug release mechanisms of LbL assembled multilayers have been demonstrated, [14][15][16][17] allowing the loading and release behavior to be repeated over a series of cycles, despite the fact that LbL-assembled multilayers are normally not durable under extreme conditions of pH or ionic strength. 8 Another improvement in controlling retarded release from LbL multilayers has been to include larger amounts of cargo, by using specic building polymers allowing the incorporation of more binding sites, 9 by the construction of thicker lms, 10 or by use of microgels or nanoparticles as drug reservoirs.…”

Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair

“…Consequently, drug was released for 7 days with different loading amounts depending on the immersion time. Ibuprofen was also incorporated into surgical sutures using a layer-by-layer deposition method [161]. In this instance, the surface of the silk surgical suture was first coated with multiple layers of chemically cross-linked poly(allylamine hydrochloride) and dextran microgels.…”