Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

Wang, Yue; An, Qi; Zhou, Yong; Niu, Yue; Akram, Raheel; Zhang, Yihe; Shi, Feng

doi:10.1039/c4tb01688b

Cited by 26 publications

(19 citation statements)

References 37 publications

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“…This result suggested an enhanced stability of the polyelectrolyte multilayer and corresponded well with our previous report. [5][6][7][8] After introducing a high gravity field to the DAS loading process while keeping other conditions identical, we observed that the absorbance after immersing DAS was thoroughly lower than that under the conventional dipping conditions (Fig. 3b), which was interpreted by the reduced surface roughness of the multilayer in the presence of a high gravity field.…”

Section: Resultsmentioning

confidence: 88%

“…Increasing the rate of mass transport from bulk solution to interface (infiltration rate) is significant for various research areas such as membrane separation, [1][2][3] interfacial chemical reaction, [4][5][6][7][8] thin film fabrication, [9][10][11][12] sensing, [13][14][15] etc. Taking the layer-by-layer assembled multilayer 9,10,[16][17][18][19][20][21] as an example, there is a paradox between increasing the loading amount and enhancing the infiltration rate because the multilayer should grow thick for high loading capacity; 22,23 this results in an increased barrier for infiltration through the multilayer, and thus, a decreased infiltration rate.…”

Section: Introductionmentioning

confidence: 99%

“…The key problem of these phenomena is the low infiltration rate of targeted species from bulk solutions to the desired locations on the interface, especially within thin films. [5][6][7][8] Therefore, it is a general challenge to enhance the interfacial diffusion/infiltration through thin films while maintaining the original film properties or functions such as adsorption behavior, 7 binding affinity, 24 separating efficiency, 26 and so on.…”

Section: Introductionmentioning

confidence: 99%

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Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

et al. 2015

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Loading functional small molecules into nano-thin films is fundamental to various research fields such as membrane separation, molecular imprinting, interfacial reaction, drug delivery etc. Currently, a general demand for enhancing the loading rate without affecting the film structures exists in most infiltration phenomena. To handle this issue, we have introduced a process intensification method of a high gravity technique, which is a versatile energy form of mechanical field well-established in industry, into the investigations on diffusion/infiltration at the molecular level. By taking a polyelectrolyte multilayer as a model thin film and a photo-reactive molecule, 4,4'-diazostilbene-2,2'-disulfonic acid disodium salt (DAS), as a model small functional molecule, we have demonstrated remarkably accelerated adsorption/infiltration of DAS into a poly(allylamine hydrochloride) (PAH)/poly(acrylic acid) (PAA) multilayer by as high as 20-fold; meanwhile, both the film property of the multilayer and photoresponsive-crosslinking function of DAS were not disturbed. Furthermore, the infiltration of DAS and the surface morphology of the multilayer could be tuned based on their high dependence on the intensity of the high gravity field regarding different rotating speeds. The mechanism of the accelerated adsorption/infiltration under the high gravity field was interpreted by the increased turbulence of the diffusing layer with the thinned laminar boundary layer and the stepwise delivery of the local concentration gradient from the solution to the interior of the multilayer. The introduction of mechanical field provides a simple and versatile strategy to address the paradox of the contradictory loading amount and loading rate, and thus to promote applications of various membrane processes.

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Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

et al. 2015

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“…The stability of the multilayers remarkably enhanced after crosslinkage. As shown in Figure S3e,f (Supporting Information), after immersed in NaOH solution (pH 12) for 30 min, the absorbance of the crosslinked multilayer decreased by less than 50%, largely due to the washing away of the residue DAS . In comparison, the absorbance of the uncrosslinked multilayer totally diminished, indicating the complete disassembly of the uncrosslinked film.…”

Section: Resultsmentioning

confidence: 95%

A New Way to Promote Molecular Drug Release during Medical Treatment: A Polyelectrolyte Matrix on a Piezoelectric–Dielectric Energy Conversion Substrate

Zhang

Tong

et al. 2018

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Enhanced drug releases in a timely manner during urgent medical treatments would significantly enhance the prognosis of patients. Inspired by the facilitated molecular transports by the potentials, an enhanced drug release strategy driven by mechanical disturbances that widely exist in medical treatment processes is proposed. This strategy is enabled by a functional material comprised of multilayers of dendrimers as the drug reservoir, which are built on a piezoelectric-dielectric flexible film with reduced graphene oxide fillers. The generated voltages are higher and last longer than that in regular piezoelectric films. Photochemical crosslinking leads to a stable drug matrix which is even sustained in electric fields and high ionic strengths. The device enhances releases of positively, negatively, and zwitterionically charged molecules in response to mechanical stimuli and supports high cell viabilities. An illustrative application is demonstrated by preparing the material on the surface of a gastric lavage tube. The results show that the release of antiemetic drug increased by 200% within 60 min in response to forces mimicking human swallowing. This study contributes an integrative material that can realize electrically triggered releases that are previously only realized using complicated electrochemical setups. It is believed that this material can facilitate medicine applications in various emergent situations.

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“…As a result, a fluorescence based method was used as an alternative for tracking the deposition of PAH/PSS bilayer. For this purpose, acridine orange (AO), which can electrically bind to the PSS layer to form PSS AO [56], was used as a tracking agent. The green fluorescent observed on Alg-Ms (Figure 3A-D) suggested the deposition of PSS, and the fluorescence intensity increased with the increase of bilayer number.…”

Section: Resultsmentioning

confidence: 99%

Layer-by-layer polyelectrolyte coating of alginate microgels for sustained release of sodium benzoate and zosteric acid

Wang

Newby

2018

Journal of Drug Delivery Science and Technology

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The potential of sustaining release of very small (Mw < 250 g/mol) hydrophilic drugs up to several days from layer-by-layer (LbL) polyelectrolyte coated alginate microgels (Alg-Ms) was investigated. One purpose is to minimize post-surgical adhesions, which develop in 12 h to 3 days after surgery. The LbL polyelectrolyte layer would serve as a diffusion barrier for their release. The LbL polyelectrolyte bilayers were prepared using poly(allylamine) (PAH) and poly(styrene sulfonate) (PSS). Sodium benzoate (NaB, Mw = 144 g/mol) and zosteric acid (ZA, Mw = 244 g/mol), two anti-inflammatory and anti-microbial compounds, were used as model drugs. A higher number of PAH/PSS bilayer lead to a greater sustained release of both drugs, and with 4 bilayers, the release of NaB and ZA was prolonged from 24 h to 72 h and 120 h, respectively. Fitting the data to the Ritger-Peppas’ equation showed that as the bilayer number increased, the release constant and/or exponent decreased, indicating the LbL PAH/PSS bilayer effectively reduced the permeability of these two very small hydrophilic drugs. The ability to prolong the release of such small hydrophilic molecules, which has rarely been investigated previously, would find broad applications in fields such as anti-adhesion treatment and antifouling coatings.

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Post-infiltration and subsequent photo-crosslinking strategy for layer-by-layer fabrication of stable dendrimers enabling repeated loading and release of hydrophobic molecules

Cited by 26 publications

References 37 publications

Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

A New Way to Promote Molecular Drug Release during Medical Treatment: A Polyelectrolyte Matrix on a Piezoelectric–Dielectric Energy Conversion Substrate

Layer-by-layer polyelectrolyte coating of alginate microgels for sustained release of sodium benzoate and zosteric acid

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