Layer-by-layer assembly of thin organic films on PTFE activated by cold atmospheric plasma

Tóth, A.; Szentmihályi, Klára; Keresztes, Zsófia; Szigyártó, Imola Csilla; Kováčik, Dušan; Černák, Mirko; Kutasi, Kinga

doi:10.1515/chem-2015-0072

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Noteworthy, plasma-treated PTFE surface lacks nitrogen-based groups content, despite the use of air plasma. The absence of nitrogen in the similar experimental conditions was also described in an article published by Tóth et al 41 Considering the concentration of specific chemical bonds achieved from high-resolution C1s spectra (Table S1), concentration of CFx groups was decreasing from initial 96% while reached the minimal amount of 61% after 10 s of plasma treatment. This agrees with the highest obtained oxidation of PTFE after 10 s of treatment, which represents the boundary for the maximal degree of PTFE surface activation.…”

Section: Resultssupporting

confidence: 75%

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Šrámková

Zahoranová

Kelar

et al. 2020

Sci Rep

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Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POxbased copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of "cold" homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days. Surface modification of polymers is crucial in many applications, where material must fulfill specific requirements concerning the surface wettability 1 , stiffness 2 , topology 3 as well as chemical reactivity 4. Adjusting the individual surface properties is critical, especially in medicine. Implantable devices or scaffolds must exhibit not only long-term stability in contact with the biological environment but also provide specific interactions with tissues, possess required mechanical or antibacterial properties, or release drugs on demand. Some applications require the material to be non-adhesive and rigid; in other cases, the good cell adhesion is desirable 5. Such control of the specific surface properties of medical implants or devices can be ensured by surface modification 6. The basic strategy for surface modification of low-cost polymers often used in medicine (polypropylene, polyethylene, polytetrafluoroethylene) includes chemical coating by a thin layer of a biocompatible polymer. Besides the polyethylene glycol (PEG) considered being a gold standard for many biomedical applications including surface modification, poly(2-oxazolines) (POx) are gradually more discussed as an available alternative 7,8. POx are accessible via cationic ring-opening polymerization (CROP), which is well controllable process providing the defined polymers with desired architecture, functional moieties, and adjustable properties. Their relevance for employing as biomedical coatings is supported by extensive biological studies of biocompatibility 9,10 , immunotoxicity 11,12 , and control of protein and cell adhesion 13 with positive results. Up to now, many different modification techniqu...

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Section: Resultssupporting

confidence: 75%

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Šrámková

Zahoranová

Kelar

et al. 2020

Sci Rep

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“…In this work, we present the surface modification of PMMA by Diffuse Coplanar Surface Dielectric Barrier Discharge (DCSDBD) operated in atmospheric pressure air, which was successfully employed in our earlier work for enhancing the hydrophilicity and thus the wettability of polytetrafluoroethylene (PTFE) . The aim of surface modification is to endow antimicrobial properties of the PMMA surface.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐ and catalysts‐free immobilization of tannic acid and polyvinylpyrrolidone onto PMMA surface by DBD plasma

Klébert

Károly

Késmárki

et al. 2017

Plasma Processes & Polymers

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Polyvinylpyrrolidone (PVP) and tannic acid (TAN) macromolecules were attached to polymethyl methacrylate (PMMA) surface in a two-step approach in order to establish a tailored tissue-friendly surface layer. First PMMA surface was activated by an air diffuse coplanar surface barrier discharge plasma and subsequently coated with these macromolecules. PVP and TAN which has antibacterial effects are widely used in food and drug industry, however have never applied for polymer surface modification. Throughout characterization measurements confirm that during plasma treatment oxygen containing functional groups (-OH, -C=O, -COOH) incorporate in the surface. 1HNMR spectroscopy verified the strong H-bonds between PVP and TAN, which rendered the layer-by-layer as- Many researches have been carried out to overcome this shortcoming of polymers including PMMA.A common approach to make the surface more hydrophilic is to modify the surface chemistry. Due to the chemical inertness of the polymeric materials their surface modification means that first they shall undergo surface activation before subsequent covalent functionalisation (Fig.1.). It was found that a hydrophilic surface created by surface modification and formation of new functional groups on the surface by oxygen plasma treatment greatly inhibited bacterial adhesion to PMMA surface [8].The hydrophilic properties, however, usually does not last long due to the ageing effect of such treatment [9]. The speed of ageing is affected by several operating factors of the treatment, includ-

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“…The treatment and modification of surfaces by reactive plasmas is a widespread method. Reactive oxygen and UV radiating plasmas have been suggested for sterilization and decontamination of surfaces, etching, and grafting of polymers, as well as for functionalization, structuring, and activation of surfaces . One of the main targets are the polymers, which find their use in biomedicine .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the flowing afterglow of a surface‐wave microwave discharge in a reactor loaded with a small diameter tube

Kutasi

Korolov

2017

Plasma Processes & Polymers

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Applying the flowing afterglow of an N2O2 surface‐wave microwave discharge it is shown, that using 500–1000 sccm gas flow rates the afterglow can efficiently travel through a 4.5 mm polymer tube placed into the afterglow reactor, as well as simultaneously inside and around the tube. The afterglow along the reactor loaded with a 5 mm I.D. quartz tube is followed through the UV emission of NO(B) molecules created in the three‐body re‐association process of N‐ and O‐atoms, and by modeling calculations. It is shown that by placing the tube into reactor the pressure and the density of species increase. Along the tube the absolute density of atoms decrease due to the pressure drop there, which can be controlled through the system's pumping efficiency.

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Layer-by-layer assembly of thin organic films on PTFE activated by cold atmospheric plasma

Cited by 5 publications

References 27 publications

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Solvent‐ and catalysts‐free immobilization of tannic acid and polyvinylpyrrolidone onto PMMA surface by DBD plasma

Characteristics of the flowing afterglow of a surface‐wave microwave discharge in a reactor loaded with a small diameter tube

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