Layer-by-Layer Assembly of Poly(lactic acid) Nanoparticles: A Facile Way to Fabricate Films for Model Drug Delivery

Jiao, Yonghua; Li, Yan; Wang, Shu; Zhang, Kai; Jia, Ying‐Gang; Fu, Yu

doi:10.1021/la101123y

Cited by 29 publications

(19 citation statements)

References 20 publications

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“…The finding can be explained by the slightly negatively surface charge of PLA, due to the presence of residual carboxyl groups, that may electrostatically repel the MMT clay. 35 Hence, from the point of building a multilayer coating on a PLA film, it is clear that the presence of a polycation is required as the primary layer on the PLA film. A polymer other than PLA is also needed in-between the MMT layers to build successfully the multilayer structure.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Transparent Films Based on PLA and Montmorillonite with Tunable Oxygen Barrier Properties

Svagan¹,

et al. 2012

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Polylactide (PLA) is viewed as a potential material to replace synthetic plastics (e.g., poly(ethylene terephthalate) (PET)) in food packaging, and there have been a number of developments in this direction. However, for PLA to be competitive in more demanding uses such as the packaging of oxygen-sensitive foods, the oxygen permeability coefficient (OP) needs to be reduced by a factor of ∼10. To achieve this, a layer-by-layer (Lbl) approach was used to assemble alternating layers of montmorillonite clay and chitosan on extruded PLA film surfaces. When 70 bilayers were applied, the OP was reduced by 99 and 96%, respectively, at 20 and 50% RH. These are, to our knowledge, the best improvements in oxygen barrier properties ever reported for a PLA/clay-based film. The process of assembling such multilayer structures was characterized using a quartz crystal microbalance with dissipation monitoring. Transmission electron microscopy revealed a well-ordered laminar structure in the deposited multilayer coatings, and light transmittance results demonstrated the high optical clarity of the coated PLA films.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Transparent Films Based on PLA and Montmorillonite with Tunable Oxygen Barrier Properties

Svagan¹,

et al. 2012

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“…As a result, the release rate increased gradually . Jiao et al fabricated poly(lactic acid) nanoparticles, which encapsulated pyrene as a model drug, and poly(ethylene imine) (PEI) LbL films as a novel drug‐delivery system. There was an initial burst in the first 20 h. They suggested that the films of poly(lactic acid) nanoparticles were promising for the sustained release of drugs.…”

Section: Resultsmentioning

confidence: 99%

“…The general concept of multilayer formation is electrostatic attraction, and it has been expanded to alternating films stabilized by hydrogen bonding, covalent bonding, hydrophobic interactions, and molecular recognition . A large number of components can be used to fabricate multilayer assemblies, including water‐soluble polyelectrolytes, natural polymers (e.g., DNA, RNA, proteins, peptides, enzymes, and polysaccharides), and advanced materials (e.g., synthetic polymers, dendritic molecules, and nanoparticles) …”

Section: Introductionmentioning

confidence: 99%

Layer‐by‐layer assembled hydrogel nanocomposite film with a high loading capacity

Yuan

et al. 2013

J of Applied Polymer Sci

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The layer‐by‐layer assembly technique is a method that widely used in the preparation of nanostructured multilayer ultrathin films. We fabricated a hydrogel nanocomposite film by alternating the deposition of a core–shell poly[(dimethylimino)(2‐hydroxy‐1,3‐propanedily) chloride] (PDMIHPC)–laponite solution and poly(acrylic acid). The growth of the deposition procedure was proven by ultraviolet–visible spectroscopy and spectroscopic ellipsometry. The surface morphology of the films was observed by scanning electron microscopy. The films could reversibly load and release methylene blue (MB) dye, which was used as an indicator. It took about 4.5 h to reach loading equilibrium at pH 9.0. The loading capacity of the film for MB was as large as 4.48 μg/cm2 per bilayer because of the introduction of the core–shell PDMIHPC–laponite as a film component. Nearly 90% of MB was released at pH 3.0 or in a 300 mM NaCl solution within 2.5 h. The loading and release processes were greatly influenced by the ionic strength and pH value of the MB solution. The hydrogel nanocomposite film showed good pH‐triggered loading‐release reversibility and suggested potential applications in controlled drug‐delivery systems and smart materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39352.

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“…Figure 12 shows a number of these polyelectrolytes. The layer-by-layer method can also employ a wide range of charged components including proteins [101,102], viruses [16], nanoparticles [103][104][105], and flaky minerals [106,107]. A number of layer-by-layer methods employ interactions such as hydrogen bond [16,[108][109][110][111] or covalent bond [112][113][114][115].…”

Section: Growth Mechanisms and Structure Of Polyelectrolyte Filmsmentioning

confidence: 99%

Membrane and Bioseparation

Mansourpanah¹,

Emamian²

2020

Advances in Membrane Technologies

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Although one of the strongest methods of purification is chromatography, the major problem of porous bed chromatography is that purification takes place using the diffusion. This will prolong the purification process and bring down the efficiency. In recent years, membrane methods have greatly overcome this limitation due to low membrane thickness, low pressure drop, and convective flow, and they are a great alternative to chromatography columns. Unfortunately, the membranes have a low surface area. For solving such problem, membrane modification with polymeric brushes and layer-by-layer adsorption in polyelectrolyte films can be attractive. Accordingly, in this chapter we introduce types of biomolecule purification methods, the best purification method, membrane modification techniques, and their limitations and assets. Also, we introduce the membrane as an attractive tool for selective purification and separation of biomolecules.

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Layer-by-Layer Assembly of Poly(lactic acid) Nanoparticles: A Facile Way to Fabricate Films for Model Drug Delivery

Cited by 29 publications

References 20 publications

Transparent Films Based on PLA and Montmorillonite with Tunable Oxygen Barrier Properties

Transparent Films Based on PLA and Montmorillonite with Tunable Oxygen Barrier Properties

Layer‐by‐layer assembled hydrogel nanocomposite film with a high loading capacity

Membrane and Bioseparation

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