Laxiflorol A, the first example of 7,8:15,16-di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora

Wang, Weiguang; Tang, Jianwei; Shi, Yi‐Ming; Du, Xue; Li, Xiaonian; Wu, Haiyan; Jiang, Heng; Li, Yan; Pu, Jian‐Xin; Sun, Han‐Dong

doi:10.1039/c4ra12704h

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…However, if the internuclear distance was less than 3 Å, the NOE correlations could also be observed even for the two spin-systems with opposite orientations . It is not possible to assign the relative configuration at C-14, C-15, and C-19 using the NOE correlations observed between vicinal protons (H-14 and H-15; H-14 and H 3 -25).…”

Section: Resultsmentioning

confidence: 99%

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Wang

Yan

et al. 2015

J. Nat. Prod.

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Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

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Section: Resultsmentioning

confidence: 99%

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Wang

Yan

et al. 2015

J. Nat. Prod.

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ChemInform Abstract: Laxiflorol A, the First Example of 7,8:15,16‐Di‐seco‐15‐nor‐21‐homo‐ent‐kauranoid from Isodon eriocalyx var. laxiflora.

et al. 2015

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Laxiflorol A, the First Example of 7,8:15,16-Di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora. -The isolation and structure elucidation of laxiflorol A (I), which is the first example of 7,8:15,16-di-seco-15-nor-21-homo--ent-kauranoid, and its precursor analogue laxiflorol B (II) from the leaves of Isodon eriocalyx var. laxiflora are described. The absolute configuration of (I) is determined by spectral methods and quantum chemical calculations. Compound (II) exhibits weak cytotoxicity. -(WANG, W.-G.; TANG, J.-W.; SHI, Y.-M.; DU, X.; LI, X.-N.; WU, H.-Y.; JIANG, H.-Y.; LI, Y.; PU*, J.-X.; SUN, H.-D.; RSC Adv. 5 (2015) 8, 6132-6135, http://dx.

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ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses

Wang

Yang

et al. 2015

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Laxiflorol A, the first example of 7,8:15,16-di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora

Abstract: Laxiflorol A (1), an unprecedented 7,8:15,16-di-seco-15-nor-21-homo-ent-kauranoid, and its precursor analogue, laxiflorol B (2), were isolated from the leaves of Isodon eriocalyx var. laxiflora.

Cited by 6 publications

References 30 publications

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

ChemInform Abstract: Laxiflorol A, the First Example of 7,8:15,16‐Di‐seco‐15‐nor‐21‐homo‐ent‐kauranoid from Isodon eriocalyx var. laxiflora.

ent-Kauranoids isolated from Isodon eriocalyx var. laxiflora and their structure activity relationship analyses

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