ChemInform Abstract: Laxiflorol A, the First Example of 7,8:15,16‐Di‐seco‐15‐nor‐21‐homo‐ent‐kauranoid from Isodon eriocalyx var. laxiflora.

Abstract

Laxiflorol A, the First Example of 7,8:15,16-Di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora. -The isolation and structure elucidation of laxiflorol A (I), which is the first example of 7,8:15,16-di-seco-15-nor-21-homo--ent-kauranoid, and its precursor analogue laxiflorol B (II) from the leaves of Isodon eriocalyx var. laxiflora are described. The absolute configuration of (I) is determined by spectral methods and quantum chemical calculations. Compound (II) exhibits weak cytotoxicity. -(WANG, W.-G.; TANG, J.-W.; SHI, Y.-M.; DU, X.; LI, X.-N.; WU, H.-Y.; JIANG, H.-Y.; LI, Y.; PU*, J.-X.; SUN, H.-D.; RSC Adv. 5 (2015) 8, 6132-6135, http://dx.