Lawsonia inermis L. – A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review

Singh, D. K.; Luqman, Suaib; Mathur, Anmol

doi:10.1016/j.indcrop.2014.11.025

Cited by 88 publications

(40 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the substitution of the 1,4-naphthoquinone skeleton (mostly in positions 2-, 3-, 5-, and 8-), they show a variety of biological activities, including the antioxidant, anticancer, antimicrobial, anti-inflammatory, antimalarial and anti-HIV activities [2–5]. …”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes

et al. 2017

View full text Add to dashboard Cite

We report in vitro and in vivo anti-inflammatory activities of a series of copper(II)-lawsone complexes of the general composition [Cu(Law)2(LN)x(H2O)(2-x)]·yH2O; where HLaw = 2-hydroxy-1,4-naphthoquinone, x = 1 when LN = pyridine (1) and 2-aminopyridine (3) and x = 2 when LN = imidazole (2), 3-aminopyridine (4), 4-aminopyridine (5), 3-hydroxypyridine (6), and 3,5-dimethylpyrazole (7). The compounds were thoroughly characterized by physical techniques, including single crystal X-ray analysis of complex 2. Some of the complexes showed the ability to suppress significantly the activation of nuclear factor κB (NF-κB) both by lipopolysaccharide (LPS) and TNF-alpha (complexes 3–7 at 100 nM level) in the similar manner as the reference drug prednisone (at 1 μM level). On the other hand, all the complexes 1–7 decreased significantly the levels of the secreted TNF-alpha after the LPS activation of THP-1 cells, thus showing the anti-inflammatory potential via both NF-κB moderation and by other mechanisms, such as influence on TNF-alpha transcription and/or translation and/or secretion. In addition, a strong intracellular pro-oxidative effect of all the complexes has been found at 100 nM dose in vitro. The ability to suppress the inflammatory response, caused by the subcutaneous application of λ-carrageenan, has been determined by in vivo testing in hind-paw edema model on rats. The most active complexes 1–3 (applied in a dose corresponding to 40 μmol Cu/kg), diminished the formation of edema simalarly as the reference drug indomethacine (applied in 10 mg/kg dose). The overall effect of the complexes, dominantly 1–3, shows similarity to anti-inflammatory drug benoxaprofen, known to induce intracellular pro-oxidative effects.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes

et al. 2017

View full text Add to dashboard Cite

show abstract

“…But this is not the only one since natural dyes are used for makeup (Eyeshades, red lipstick. ), for care, toothpaste mouthwashes, and several other` 1`r applications [5,[29][30][31].…”

Section: Use Natural Dyes Of Plant Originmentioning

confidence: 99%

Review: From Screening to Application of Moroccan Dyeing Plants: Chemical Groups and Botanical Distribution

Imane

Idrissi

Draoui

et al. 2016

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Many dyes are contained in plants and are used for coloring a medium. They are characterized by their content of dyes molecules. They stimulate interest because they are part of a sustainable development approach. There are several chemicals families of plant dye which are contained in more than 450 plants known around the world. In this article, a study based on literature allowed us to realize an inventory of the main dyes plants potentially present in Morocco. A list of 117 plants was established specifying their botanical families, chemical Composition, Colors and parts of the plant used.

show abstract

“…Henna extracts are now commercialized for skin, wool and cotton dyeing purposes in Asia and Africa. Despite this broad spectrum of biological properties, the phytotoxicity of lawsone has not been fully studied . It is also well known that the position of the hydroxyl group in this family of compounds is crucial for their biological activities as it affects the redox potentials and pro‐oxidant activities …”

Section: Introductionmentioning

confidence: 99%

Structure‐activity relationship studies on naphthoquinone analogs. The search for new herbicides based on natural products

Durán

Chinchilla

Molinillo

et al. 2019

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND Allelopathy and bioassays constitute fundamental tools in the search for new herbicide templates. The work described here is a continuation of a previous study focused on the structure–activity relationships between transport phenomena and phytotoxic activity. Different modifications were made to the naphthoquinone backbone and two key factors were identified as being responsible for changes in activity: lipophilicity and the nature of the functional group. The study of other naturally occurring and semi‐synthetic naphthoquinones was also proposed. RESULTS A total of 12 5‐O‐acyl plumbagins and 18 analogs with unsaturated and aromatic substituents at positions 2 and 5 were synthesized. These compounds were evaluated in the wheat coleoptile bioassay and against Standard Target Species (STS) and three weeds, namely Echinochloa crus‐galli L., Lolium rigidum Gaud. and Lolium perenne L. A strong structure–function relationship was observed for the different naphthoquinones and root and shoot length were the parameters that were most affected. CONCLUSION Strong inhibitory effects were observed for the isomeric forms 23 and 33 and the derivatives with a free hydroxyl group, i.e. 24 and 30, gave values higher than 70% inhibition for root length in barnyardgrass and perennial ryegrass. These results highlight the potential of these compounds as models in the development of herbicides based on natural products. © 2019 Society of Chemical Industry

show abstract

Lawsonia inermis L. – A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review

Cited by 88 publications

References 88 publications

In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes

In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes

Review: From Screening to Application of Moroccan Dyeing Plants: Chemical Groups and Botanical Distribution

Structure‐activity relationship studies on naphthoquinone analogs. The search for new herbicides based on natural products

Contact Info

Product

Resources

About