Laws, Regulations, Guidelines, and Principles Pertaining to Laboratory Animals in Southeast Asia

Gettayacamin, Montip; Grant, Richard; Holl, Davun; Heidrich, John E.; Sorn, San; Paramastri, Yasmina; Winoto, Imelda Liunanita; Sajuthi, Dondin; Goh, Yong Meng; Mutalib, Abdul; Resuello, Ranillo Rodrigo G.; Estacio, Maria Amelita C.; Tuplano, Joel Villa; Wong, Hon Mun; Daludado, Cheryl Inguito; Kunjara, Pattamarat; Donavanik, Jade; Chatikavanij, Pradon; Pholpramool, Chumpol; Quốc, Nguyễn Bảo; Tiep, Nguyen Ba

doi:10.1016/b978-0-12-849880-4.00011-8

Cited by 4 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Current guidelines for noise surveys in animal facilities recommend that multiple frequencies are considered, and typically mention that mice can hear ultrasonic frequencies. [6][7][8]10 However, the guidelines do not make specific recommendations regarding the range of frequencies to consider, the ideal length of surveys or the distance from potential noise sources that measurements should be performed. This lack of specificity prevents standardisation, meaning that mice in different facilities may have vastly different acoustic environments.…”

Section: Discussionmentioning

confidence: 99%

“…Considerable research effort has focussed on determining the environmental conditions most appropriate for each species most commonly used in scientific studies; the basis of legislation regarding the use of animals in many countries is informed by these data. [6][7][8][9] The importance of the maintenance of certain environmental parameters within strict limits is not underestimated by those working with and caring for animals. Animal facilities have systems and procedures in place to prevent deviations from the limits outlined in animal use legislation, and have contingency plans in place in the event of a failure.…”

Section: Introductionmentioning

confidence: 99%

“…31,33 In response, governmental bodies and special interest groups released guidelines for monitoring and controlling the acoustic environment. [6][7][8]10 For example, the Home Office in the UK recommends that noise levels are assessed at a range of frequencies and that extraneous noise is minimised. 10 The current guidelines on monitoring the acoustic environment encourages animal housing facilities to monitor noise levels and highlights the importance of this for mouse welfare.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigating audible and ultrasonic noise in modern animal facilities

et al. 2022

View full text Add to dashboard Cite

Background: The environmental housing conditions of laboratory animals are important for both welfare and reliable, reproducible data. Guidelines currently exist for factors such as lighting cycles, temperature, humidity, and noise, however, for the latter the current guidelines may overlook important details. In the case of the most common laboratory species, the mouse, the range of frequencies they can hear is far higher than that of humans. The current guidelines briefly mention that ultrasonic (>20 kHz) frequencies can adversely affect mice, and that the acoustic environment should be checked, though no recommendations are provided relating to acceptable levels of ultrasonic noise. Methods: To investigate the ultrasonic environment in a large mouse breeding facility (the Mary Lyon Centre at MRC Harwell), we compared two systems, the Hottinger Bruel and Kjaer PULSE sound analyser, and an Avisoft Bioacoustics system. Potential noise sources were selected; we used the PULSE system to undertake real-time Fourier analysis of noise up to 100 kHz, and the Avisoft system to record noise up to 125 kHz for later analysis. The microphones from both systems were positioned consistently at the same distance from the source and environmental conditions were identical. In order to investigate our result further, a third system, the AudioMoth (Open Acoustic Devices), was also used for recording. We used DeepSqueak software for most of the recording analysis and, in some cases, we also undertook further spectral analysis using RX8 (iZotope, USA). Results: We found that both systems can detect a range of ultrasonic noise sources, and here discuss the benefits and limitations of each approach. Conclusions: We conclude that measuring the acoustic environment of animal facilities, including ultrasonic frequencies that may adversely affect the animals housed, will contribute to minimising disruption to animal welfare and perturbations in scientific research.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Investigating audible and ultrasonic noise in modern animal facilities

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Komisi etik hewan dikenal dengan istilah Institutional Animal Care and Use Committee (IACUC) di berbagai negara, dan merupakan salah satu perangkat kunci dalam pengawasan atau oversight penerapan kesejahteraan hewan di institusi (National Research Council 2011). Berdasarkan standar internasional, keberadaan suatu oversight body seperti IACUC yang berfungsi optimal merupakan salah satu syarat mutlak perolehan akreditasi dan lisensi institusi yang melaksanakan kegiatan ilmiah melibatkan hewan (Baar et al 2018;Bradfield et al 2018;Gettayacamin et al 2018). Di Indonesia, belum terdapat aturan yang mewajibkan keberadaan komisi etik di institusi yang melakukan penelitian menggunakan hewan coba.…”

Section: Peran Dan Fungsi Komisi Etik Hewanunclassified

“…Keberadaan dua jenis komisi etik yang berbeda sesuai subyek penelitian merupakan hal yang sejalan dengan standar yang berlaku di berbagai negara seperti Amerika Serikat, Kanada, dan Singapura (Baar et al 2018;Bradfield et al 2018;Gettayacamin et al 2018). Namun, di Indonesia tidak ada aturan tegas tentang pemisahan komisi berbasis subyek penelitian sehingga cukup banyak institusi yang menggabungkan kaji etik penelitian dengan subyek hewan dan yang mengikutsertakan manusia dalam naungan komisi yang sama, yakni Komisi Etik Penelitian Kesehatan (KEPK) (Wahyuwardani et al 2020).…”

Section: Peran Dan Fungsi Komisi Etik Hewanunclassified

Standarisasi Penjaminan Kesejahteraan Hewan Untuk Kemajuan Riset Biomedis

Dewi¹,

Darusman²,

Pamungkas³

2022

Agro-Maritim

View full text Add to dashboard Cite

Pengembangan berbagai obat, vaksin dan produk kesehatan memerlukan tahap penelitian dan pengujian pada hewan laboratorium/hewan coba. Kesejahteraan hewan selama pemeliharan dan penggunaannya dalam studi merupakan salah satu faktor penting yang menentukan kesahihan hasil, dan pemenuhannya semakin menjadi sorotan publik dan tuntutan global. Diperlukan aturan hukum, kebijakan dan pedoman nasional untuk menjamin implementasi prinsip kesejahteraan hewan yang terstandar di berbagai institusi di Indonesia, dan mengacu pada standar internasional. Kajian ini bertujuan menelaah aspek legal di Indonesia yang mengatur implementasi prinsip etik dan kesejahteraan hewan di bidang penelitian biomedis, dan mengidentifikasi kebijakan dan pedoman yang diperlukan untuk mencapai standarisasi penjaminan tersebut.

show abstract

Animal ethics in biology teaching and research in selected Asian countries

Wallis

2023

JPBI

View full text Add to dashboard Cite

Governance and regulation of the use of live animals in research and teaching is examined in Australia, Malaysia, Indonesia, the Philippines, Singapore, Thailand, China, Japan and India. A comparison of the systems in different countries will enable the determination of best practice and fit-for-purpose regulation. The most comprehensive government regulation of animal welfare in institutions covers a broad range of animals and institutions are required to have an Institutional Animal Care and Use Committee, whose membership is specified in guidelines or regulations. The work of the Committees is rigorously overseen by government and facilities that use live animals are audited externally. All countries examined have legislation governing the use of live animals in research, although only Australia and Malaysia have a fully equivalent mandated oversight of teaching. Teaching that uses live animals is partly covered in the Philippines, Japan, Singapore and Thailand This paper thus aims to review the regulation of animal use in different Asian jurisdictions in order to determine best practices that are appropriate to those settings. The most comprehensive oversight is provided in Australia and Malaysia that essentially use the same regulatory framework.

show abstract

Laws, Regulations, Guidelines, and Principles Pertaining to Laboratory Animals in Southeast Asia

Cited by 4 publications

References 3 publications

Investigating audible and ultrasonic noise in modern animal facilities

Investigating audible and ultrasonic noise in modern animal facilities

Standarisasi Penjaminan Kesejahteraan Hewan Untuk Kemajuan Riset Biomedis

Animal ethics in biology teaching and research in selected Asian countries

Contact Info

Product

Resources

About