Laurate Hydroxylation and Drug Metabolism in Pig Liver and Kidney Microsomes and in Reconstituted Systems From Pig Liver and Kidney

Masters, B.S.S.; Yasukochi, Yukio; Okita, Richard T.; Parkhill, Linda; Taniguchi, Hiroyuki; Dees, Jane H.

doi:10.1016/b978-0-12-187702-6.50020-7

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1982

1997

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Cited by 6 publications

(1 citation statement)

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“…The difference between our results and those of Ichihara et al (15) in pigs can not be clearly explained at present. However, in a recent paper, Masters et al (16) reported that the absorption peak of purified renal microsomal cytochrome P-450 obtained from the miniature pig was at 450 nm, so strain difference seems to be one of the causes.…”

Section: Discussionmentioning

confidence: 99%

A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.

et al. 1982

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Section: Discussionmentioning

confidence: 99%

A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.

et al. 1982

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The participation of soluble factors in the ω‐oxidation of fatty acids in the liver of the sheep

Hare¹,

Wahle²

1991

Lipids

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The removal of soluble components from an ovine hepatic microsomal preparation decreased the omega-hydroxylation of dodecanoic and hexadecanoic acids. The results suggest that one or more soluble components play a role in the microsomal omega-hydroxylation of fatty acids. The possible roles in the reaction of catalase (known to stimulate the microsomal desaturations of fatty acids and alkylglycerols) and superoxide dismutase were investigated. The addition of these enzymes to the complete (but not the washed) microsomal preparation stimulated both the initial omega-hydroxylation reaction and the subsequent dehydrogenation reactions of the omega-oxidation pathway. The similarity of the effects of catalase and superoxide dismutase and stimulation of two different steps of the omega-oxidation pathway suggest that these agents are acting indirectly by removing active oxygen species rather than directly on the enzymes of microsomal fatty acid omega-hydroxylation.

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Pharmacological and Toxicological Implications of Multiple Cytochromes P-450

Conney

Levin

1982

Biochemical Immunological Pharmacology

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Laurate Hydroxylation and Drug Metabolism in Pig Liver and Kidney Microsomes and in Reconstituted Systems From Pig Liver and Kidney

Cited by 6 publications

References 20 publications

A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.

A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.

The participation of soluble factors in the ω‐oxidation of fatty acids in the liver of the sheep

Pharmacological and Toxicological Implications of Multiple Cytochromes P-450

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