Latex extractables of Calotropis gigantea

A New Cytotoxic Pregnanone from Calotropis gigantea

“…The chemical constituents of C . gigantea have been extensively investigated, leading to the isolation of many cardenolides [ 2 , 3 , 4 , 5 ], flavonoids [ 6 ], terpenes [ 7 , 8 , 9 , 10 ], pregnanes [ 11 , 12 ] and a nonprotein amino acid [ 13 ]. During our screening for cytotoxic agents from tropical medicinal plants, the ethanol extract of the roots of C. gigantea showed cytotoxic activity towards human chronic myelogenous leukemia (K562) and human gastric cancer (SGC-7901) cell lines in vitro by MTT method with IC 50 values of 9.7 μ g/mL and 6.7 μ g/mL, respectively.…”

Rapid Identification of Calotropagenin Glycosides Using High‐Performance Liquid Chromatography Electrospray Ionisation Tandem Mass Spectrometry

“…The genus Calotropis has been the target of numerous chemical investigations, leading to the isolation of many cardenolides (Seiber et al , ; Qasim Khan and Malik, ; Kitagawa et al , ; Shaker et al , ), flavonoids (Thakur et al , ; Sen et al , ), terpenes (Thakur et al ; Bhutani et al , ) and a non‐protein amino acid (Pari et al , ; Suparpprom and Vilaivan, ). Calotropis procera (Asclepiadaceae) is called “Rakta Arka” in ancient Indian Ayurvedic medicine (Mueen Ahmed et al , ) and is abundant throughout India, from the Himalayas to southern India.…”

Antimicrobial and Cytotoxic Activity of Di-(2-ethylhexyl) Phthalate and Anhydrosophoradiol-3-acetate Isolated fromCalotropis gigantea(Linn.) Flower

“…Various parts of this plant have been reported to possess multiple therapeutic properties like anti-inflammatory, analgesic, anticonvulsant, anxiolytic, sedative, antidiarrhoeal and antipyretic (Adak and Gupta, 2006; Argal and Pathak, 2006; Chitme et al, 2004; Chitme et al, 2005). A literature review showed that Calotropis gigantea contained cardenolide glycosides (Mueen et al, 2005; Lhinhatrakool and Sutthivaiyakit, 2006; Kiuchi et al, 1998), pregnanes (Kitagawa et al, 1992; Shibuya et al, 1992), a nonprotein amino acid (Pari et al, 1998), terpenes (Gupta and Ali, 2000; Thakur et al, 1984; Anjaneyulu and Row, 1968), Flavonoids (Sen et al, 1992) and steroids (Habib et al, 2007; Basu and Nath, 1934). Powdered flowers of Calotropis gigantea , in small doses, are also useful in the treatment of colds, cough, asthma, catarrh, indigestion, inflammatory diseases and loss of appetite (Ghani, 2003).…”