Latex allergen in respirable particulate air pollution

Williams, P. Brock; Buhr, M. P.; Weber, Richard W.; Volz, Micheal A.; Koepke, Jerald W.; Selner, John C.

doi:10.1016/s0091-6749(95)70156-7

Cited by 62 publications

(24 citation statements)

References 35 publications

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“…Latex allergen activity was observed in all three tire extracts. This is consistent with recent published work by Wllliams et al (25,26) who showed inhibition of a Pharmacia CAP latex immunoassay (Pharmacia Diagnostics Inc., Fairfield, NJ) by the extract from a steelbelted radial tire. In contrast in the present study, we characterize latex allergens in the environment through the systematic examination of a sample of particulate matter deposited from the atmosphere adjacent to a curve on a freeway connection and through a complete 1-year air monitoring experiment in two major southern California cities.…”

Section: Resultssupporting

confidence: 92%

Latex allergens in tire dust and airborne particles.

Miguel

Cass

Weiss

et al. 1996

Environ Health Perspect

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Section: Resultssupporting

confidence: 92%

Latex allergens in tire dust and airborne particles.

Miguel

Cass

Weiss

et al. 1996

Environ Health Perspect

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“…Alternatively, if traffic exposure at short distance were the cause for the increased prevalence of sensitisation, it would have to be mediated via an effect or substance that is less easily dispersed in the surroundings than benzene, soot or NO 2 . Larger particles may display such characteristics, and dust containing latex or carbon has been implicated in health effects of traffic [30]. However, a recent study found no increase in latex sensitisation in children living close to busy streets [31].…”

Section: Discussionmentioning

confidence: 99%

Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children

et al. 2003

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Conflicting results have been reported for the relationship between traffic exposure and inception of atopy. The effect of traffic on the prevalence of asthma and atopy at school age was investigated in a representative population.Random samples of schoolchildren (n=7,509, response rate 83.7%) were studied using the International Study of Asthma and Allergies in Childhood phase-II protocol with skin-prick tests, measurements of specific immunoglobulin E and lung function. Traffic exposure was assessed via traffic counts and by an emission model which predicted soot, benzene and nitrogen dioxide (NO 2 ).Traffic counts were associated with current asthma, wheeze and cough. In children with tobacco-smoke exposure, traffic volume was additionally associated with a positive skin-prick test. Cough was associated with soot, benzene and NO 2 , current asthma with soot and benzene, and current wheeze with benzene and NO 2 . No pollutant was associated with allergic sensitisation.High vehicle traffic was associated with asthma, cough and wheeze, and in children additionally exposed to environmental tobacco smoke, with allergic sensitisation. However, effects of socioeconomic factors associated with living close to busy roads cannot be ruled out. Eur Respir J 2003; 21: 956-963.

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“…Diesel exhaust [13] and latex particles [14] from tyre dust have both been implicated in the enhancement of respiratory tract immunoglobulin E production. On the other hand, human experimental exposure to NO 2 at 100 ppb has recently been demonstrated to increase allergen responsiveness [15].…”

Section: Discussionmentioning

confidence: 99%

Traffic-related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds

Studnicka¹,

Hackl²,

Pischinger³

et al. 1997

Eur Respir J

129

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The aim of this study was to determine whether outdoor nitrogen dioxide (NO 2 ) was associated with the prevalence of asthma and respiratory symptoms.In eight nonurban communities, 843 children resident for a minimum of 2 yrs were studied. Since industrial sources of air pollution were at least 20 km away from the study communities, NO 2 was considered to primarily indicate trafficrelated air pollution. NO 2 was recorded at central monitors, and the 3 yr mean exposure was calculated. Asthma and respiratory symptoms were assessed according to the International Study on Asthma and Allergy in Childhood.Prevalence of asthma at some time ("ever asthma") was associated with longterm NO 2 . In parallel with increasing levels of NO 2 (community specific 3 yr mean 6.0-17.0 parts per billion (ppb)), asthma prevalence was 2.5, 1.4, 1.6, 2.3, 3.4, 3.6, 7.6 and 8.5%, respectively (p=0.002 for trend). The prevalence odds ratios (PORs) for "ever asthma", following adjustment for gender, age, parental education, passive smoke exposure, type of indoor heating, and parental asthma, were 1.28 (95% confidence interval (95% CI) 0.20-7.98), 2.14 (95% CI 0.40-11.3) and 5.81 (95% CI 1.27-26.5), when each of two communities with low, regular and high NO 2 , respectively, were compared with the two communities with very low NO 2 . For symptoms "wheeze" (adjusted PORs for increased NO 2 : 1.47, 1.23 and 2.27) and "cough apart from colds" (adjusted PORs for increased NO 2 : 1.49, 1.93 and 2.07), a similar trend was seen.In this study a significant relationship was observed between traffic-related nitrogen dioxide and the prevalence of asthma and symptoms. Whether this association is causal has to be tested in longitudinal studies.

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Latex allergen in respirable particulate air pollution

Cited by 62 publications

References 35 publications

Latex allergens in tire dust and airborne particles.

Latex allergens in tire dust and airborne particles.

Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children

Traffic-related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds

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