Lateralization of striatal dopamine (D2) receptors in normal rats

Schneider, Linda; Murphy, Randall B.; Coons, Edgar E.

doi:10.1016/0304-3940(82)90385-8

Cited by 65 publications

(23 citation statements)

References 14 publications

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“…There were no significant differences in VS/NAc activation between hemispheres in either condition. Qualitatively, it appears that the mean activation is greater in the right hemisphere than the left hemisphere in the smoking condition and greater in the left hemisphere than the right hemisphere in the abstinent condition, which is consistent with animal studies (Bortolozzi et al 2003;Schneider et al 1982;Stein et al 1998). …”

Section: Discussionsupporting

confidence: 75%

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study

David

Munafò

Johansen‐Berg

et al. 2007

Brain Imaging and Behavior

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To achieve greater understanding of the brain mechanisms underlying nicotine craving in female smokers, we examined the influence of nicotine non-abstinence vs. acute nicotine abstinence on cueelicited activation of the ventral striatum. Eight female smokers underwent an event-related functional magnetic resonance imaging (fMRI) paradigm presenting randomized sequences of smoking-related and non-smoking related pictures. Participants were asked to indicate by a key press the gender of individuals in smoking-related and non-smoking related pictures (gender discrimination task), to maintain and evaluate attention to the pictures. There was a significant effect of smoking condition on reaction times (RT) for a gender discrimination task intended to assess and maintain attention to the photographs-suggesting a deprivation effect of acute nicotine abstinence and a statistical trend indicating greater RTs for smoking cues than neutral cues. BOLD contrast (smoking vs. non-smoking cues) was greater in the non-abstinent vs. acutely abstinent conditions in the ventral striatum including the nucleus accumbens (VS/NAc). Moreover, a significant positive correlation was observed between baseline cigarette craving prior to scanning and VS/NAc activation (r=0.84, p=0.009), but only in the non-abstinent condition. These results may either be explained by ceiling effects of nicotine withdrawal in the abstinent condition or, may indicate reduced relative activation (smoking vs. neutral contrast) in the VS/NAc in the abstinent vs. non-abstinent conditions in this group of female smokers.

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Section: Discussionsupporting

confidence: 75%

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study

David

Munafò

Johansen‐Berg

et al. 2007

Brain Imaging and Behavior

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“…While such trophic activity following DA-depletion was noted only in young adults older animals did not show a change over respective baselines (Collier et al 2005), thus indicating loss of compensatory hemispheric activity and providing evidence for enhanced hemispheric vulnerability in the aged and in PD. Schneider et al (1982) found a 23% greater binding density of 3 H-spiroperidol in the right striatum in old rats and a greater receptor population of dopamine D1 and D2 was found in the right basal ganglia in contrast to the left (Giardino 1996). Additionally, a greater up-regulation of dopamine receptors (D2) in the right striatum compared to the left is following an ipsilateral lesion in rats (Xu et al 2005).…”

Section: Mptp Model and Lateralisationmentioning

confidence: 93%

The significance of neuronal lateralisation in Parkinson’s disease

Riederer

Sian-Hülsmann

2012

J Neural Transm

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The destruction of the dopaminergic neurons in the substantia nigra (SN) and consequent depletion of striatal dopamine elicits the main movement deficits related to Parkinson's disease (PD). In the early stages of the illness, the motor symptoms are often exhibited asymmetrically. Thus, the onset of PD features starts on either the right or left side. The side of onset appears to determine the prognosis of the disorder and other features, such as right-side tremor dominance has a better prognosis in contrast to left-side dominant bradykinesia-rigidity. In addition, left-side onset of motor features is associated with cognitive decline. Therefore, an intricate relation appears to exist between the side of disease onset and progression/severity and other non-motor symptoms. Unilateral PD in turn corresponds to neuronal nigrostriatal degeneration in the contralateral hemisphere. Indeed positron emission tomography has demonstrated a positive correlation between symptom asymmetry and brain function (Hoorn et al. Parkinsonism Relat Disord 17:58-60, 2011), which corresponds to a unilateral pattern of degeneration. This phenomenon appears to be exclusive to PD. Additionally, the variation in motor symptom(s) dominance exhibited in the disorder conforms to the notion that PD is a spectrum disease with many sub-groups. Thus, clinical and post mortem studies on "lateralisation" may serve as a vital tool in understanding the mechanism(s) eliciting the characteristic destruction of the SN neurons. Additionally, it may be employed as a predictive indicator for the symptomology and prognosis of the illness thus allowing selective treatment strategies targeted at the pronounced hemispheric degeneration.

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“…These results are in line with those of Sullivan and Szechtman [4], who also reported higher DOPAC/DA contents in unlesioned rats in the right striatum and cortex, whereas they did not find DAergic differences in the amygdala and nucleus accum-bens. Evidence for DAergic lateralisation in this latter brain region, however, comes from another study, showing a trend for higher densities of D2 receptors in the right ventral striatum [2]. DAergic lateralisation in the medial prefrontal cortex was also found in a study by Slopsema et al [31].…”

Section: Neurochemical Lateralisationmentioning

confidence: 84%

“…Brain lateralisation has been demonstrated in the rat for several neurotransmitter systems, especially dopamine (DA). Here, asymmetries were reported for the nigrostriatal system and the frontal cortex [2][3][4][5]. The direction of these asym-metries differed across studies, possibly reflecting strain or sex differences.…”

Section: Introductionmentioning

confidence: 94%

Dopaminergic Lateralisation in the Forebrain: Relations to Behavioural Asymmetries and Anxiety in Male Wistar Rats

Thiel

Schwarting²

2001

Neuropsychobiology

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Neurochemical lateralisation has been demonstrated in dopaminergic systems in the rat brain, and it has been suggested that such lateralisation might contribute to asymmetric and emotional behaviour. Here, we investigated dopaminergic brain lateralisation in relation to spontaneous and drug-induced behavioural asymmetries, and to emotional behaviour in a sample of 24 male Wistar rats. Asymmetric behaviour was measured in the open field in the undrugged state and after a systemic challenge with the muscarinic receptor antagonist scopolamine (0.5 mg/kg). Emotional behaviour was measured in the elevated plus-maze. Dopaminergic lateralisation was assessed by means of a post-mortem analysis of tissue dopamine (DA) and dihydroxyphenyl acetic acid (DOPAC) content. We found higher DOPAC/DA ratios in the neostriatum, ventral striatum, frontal cortex and amygdala of the right hemisphere. In the open field, the complete sample of rats did not show a left/right asymmetry in spontaneous behaviour, whereas systemic scopolamine induced a left-sided preference in thigmotactic scanning. A correlational analysis yielded individual relationships between behaviour and post-mortem neurochemistry, since lateralisation of DOPAC/DA ratios in favour of the right ventral striatum was related to right-side thigmotaxis. Furthermore, a right dopaminergic lateralisation in the frontal cortex was associated with lower anxiety. The study indicates that asymmetries in ventral striatal dopamine might contribute to side preferences in thigmotactic scanning while frontal dopaminergic lateralisation might influence emotional processing.

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Lateralization of striatal dopamine (D2) receptors in normal rats

Cited by 65 publications

References 14 publications

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study

The significance of neuronal lateralisation in Parkinson’s disease

Dopaminergic Lateralisation in the Forebrain: Relations to Behavioural Asymmetries and Anxiety in Male Wistar Rats

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