Laterality of Breast Cancer - is it true?

Badru, Faidah; Chianakwalam, C.; Stevenson, V.

doi:10.1016/j.ejso.2011.08.044

Cited by 3 publications

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“… -Laterality ratio is 1.06 (consistent with international reported range). -Laterality ratio was increasing with increasing age (1.187) -Higher Family History (40.2%) -Locally advanced and distant metastatic tumor stages −5-year survival was statistically significant with size of tumor −5- year survival was statistically significant with stage of tumor -Age < 50 years −25% Nulliparity -Tumor size > 5 cm -Histopathology IDC mostly NST -Positive HER2 -Positive lymph node status -Higher local recurrence − 5- year survival was not statistically significant with age of patient − 5- year survival was not statistically significant with family history -Lower Family history (27.8%) -Early tumor stage − 5-year survival was statistically significant with stage of tumor −17% Nulliparity -Higher breastfeeding history -Tumor size = or < 5 cm -Histopathology IDC ST and DCIS -Negative HER2 -Frequent multifocality -Higher systemic recurrence − 5-year survival was not statistically significant with size of tumor − 5- year survival was not statistically significant with age of patient − 5- year survival was not statistically significant with family history Badru F et al, 201 1[ 1 ]. Positive laterality Not Applicable Right-handed patients find small lesions in the left-side breast earlier.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Laterality is a recognized fact in breast cancer patients [ 1 , 2 ]. Left-sided breast cancer incidence is higher than right-sided breast cancer in a ratio varying from 1.05 to 1.26 [ 1 ]. Fellenberg was one of the first to recognize the left-sided predilection of breast cancer while analyzing the 1933–1935 Swiss Cancer Census [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fellenberg was one of the first to recognize the left-sided predilection of breast cancer while analyzing the 1933–1935 Swiss Cancer Census [ 2 ]. Although many theories were proposed to explain this side disparity, no clear explanation has been achieved [ 1 – 3 ]. One study suggested that the tissue mass in paired organs, like the breasts, is asymmetrical and more tissue is located in the left breast, contributing to the mild left-sided predilection of breast cancer [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Is laterality in breast Cancer still worth studying? Local experience in Bahrain

et al. 2022

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Background Laterality in breast cancer means an increased frequency of left-sided breast cancers compared to right-sided breast cancers ranging between 1.05 and 1.26. It was first described in 1935 by Fellenberg, Sweden. The explanation of this phenomenon is not clear, but the association with other factors was found. This study aimed to explore the laterality of breast cancer in Bahrain as a model for Arabian countries. The association of laterality with the clinicopathological characteristics of the tumor was also analyzed to explore any applied clinical value. Methods This is a cross-sectional, retrospective review of a particular ethnic population to study laterality of breast cancer versus a number of clinicopathological factors, as well as prognosis. The study analyzed 228 breast cancer patients treated in Arabian Gulf University facilities in Bahrain between 1999 and 2020. Three bilateral breast cancer and two malignant phyllodes patients were excluded. The following variables were analyzed: laterality ratio (Lt/Rt) and the association between laterality and clinicopathological characteristics (age at diagnosis, family history of malignancy, size of the tumor, tumor grade, histological type, hormonal receptors and HER2, axillary lymph node status, tumor stage, five-year survival rate, nulliparity, and multifocality). Results The laterality ratio (Lt/Rt) was 1.06 and was 0.97 for patients below 50 years of age, and 1.19 for patients 50 years of age and above. Analysis of our data showed a statistically significant association between laterality and tumor stage (p. value =0.025) at presentation, and laterality and family history of malignancy (p. value =0.052). Right-sided breast cancer was associated with a higher positive family history of malignancy and an increased ratio of locally advanced and metastatic disease, and a reduced 5-year survival in relation to size and stage. Left-sided breast cancer was associated with higher early tumor stage. Conclusion This is the first study exploring the issue of breast cancer laterality in a defined Arabian population. The laterality ratio in this study was 1.06, which is consistent with the globally published range (1.05 to 1.26) and is increasing with increasing age. The association between breast cancer laterality, and the hormonal and HER2 is still not widely addressed in the available literature, although other clinicopathological characteristics were extensively analyzed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is laterality in breast Cancer still worth studying? Local experience in Bahrain

et al. 2022

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“…No statistically significant difference was observed between the left or the right laterality of breast cancer and clinical outcome [ 38 ]. However, reasons given for the conflicting reports of the laterality of breast cancer were detection bias, handiness of the patients and size differences of the patients breasts [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

A longitudinal study of the prevalence and characteristics of breast disorders detected by clinical breast examination during pregnancy and six months postpartum in Ibadan, Southwestern Nigeria

et al. 2018

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BackgroundBreast disorders cause great anxiety for women especially when they occur in pregnancy because breast cancer is the most common cause of cancer related deaths in women. Majority of the disorders are Benign Breast Diseases (BBD) with various degrees of associated breast cancer risks. With increasing breast cancer awareness in Nigeria, we sought to determine the prevalence and characteristics of breast disorders among a cohort of pregnant women.MethodsA longitudinal study of 1248 pregnant women recruited in their first trimester- till 26 weeks gestational age consecutively from selected antenatal clinics (ANCs), in Ibadan, Southwest Nigeria. A pretested interviewer- administered questionnaire was used to collect information at recruitment. Clinical Breast Examination (CBE) using MammaCare® technique was performed at recruitment and follow up visits at third trimester, six weeks postpartum and six months postpartum. Women with breast disorders were referred for Breast Ultrasound Scan (BUS) and those with Breast Imaging Reporting and Data System (BIRADS) ≥4 had ultrasound guided biopsy. Statistical analysis was performed using Stata version 14.ResultsMean age of participants was 29.7 ± 5.2 years and mean gestational age at recruitment was 20.4 ± 4.4 weeks. Seventy-two participants (5.8%) had a past history of BBD and 345 (27.6%) were primigravidae. Overall, breast disorder was detected among 223 (17.9%) participants and 149 (11.9%) had it detected at baseline. Findings from the CBE showed that 208 (69.6%) of 299 breast disorders signs found were palpable lumps or thickenings in the breast, 28 (9.4%) were persistent pain, and 63 (21.1%) were abscesses, infection and mastitis. Twenty out of 127 (15.7%) participants who had BUS performed were classified as BIRADS ≥3. Lesions found by BUS were reactive lymph nodes (42.5%), prominent ducts (27.1%), fibroadenoma (9.6%), breast cysts (3.8%) and fibrocystic changes (2.5%). No malignant pathology was found on ultrasound guided biopsy.ConclusionsBreast lump is a major breast disorder among pregnant women attending antenatal clinics in Ibadan. Routine clinical breast examination and follow up of pregnant women found with breast disorders could facilitate early detection of pregnancy associated breast cancer in low resource settings.

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Response of Caf Regimen as Neo-Adjuvant Chemotherapy in Downstaging Locally Advanced Breast Carcinoma

Grover

Sivarajan

Suganth

et al. 2021

Global Journal for Research Analysis

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BACKGROUND:In India, locally advanced breast cancer (LABC) is responsible for 30 - 35% of all breast cancer cases. The purpose of preoperative chemotherapy is that it is capable of shrinking large primary tumors rendering many inoperable patients operable METHODS: 2 2 The doses of the drugs used were Cyclophosphamide - 600 mg/m IV infusion, Adriamycin - 50 mg/m IV infusion 2 and 5 uorouracil (FU) - 600 mg/m IV infusion. Clinical response was noted after 3 weeks of third cycle of NACT which was assessed according to RECIST criteria RESULTS: 78.1% of our patients responded to NACT (cCR + cPR) with pCR in 17.2% of patients. percentage of complete response was higher for patients in stage IIIA than for the patient in stage IIIB CONCLUSION: neo-adjuvant chemotherapy integrated into a multi-modality program is the standard management in patients with locally advanced breast carcinoma. The patients with pathological complete response and patients without axillary lymph node were associated with improved outcome after neo adjuvant chemo therapy

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Laterality of Breast Cancer - is it true?

Cited by 3 publications

References 0 publications

Is laterality in breast Cancer still worth studying? Local experience in Bahrain

Is laterality in breast Cancer still worth studying? Local experience in Bahrain

A longitudinal study of the prevalence and characteristics of breast disorders detected by clinical breast examination during pregnancy and six months postpartum in Ibadan, Southwestern Nigeria

Response of Caf Regimen as Neo-Adjuvant Chemotherapy in Downstaging Locally Advanced Breast Carcinoma

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