Response of Caf Regimen as Neo-Adjuvant Chemotherapy in Downstaging Locally Advanced Breast Carcinoma

Abstract

BACKGROUND:In India, locally advanced breast cancer (LABC) is responsible for 30 - 35% of all breast cancer cases. The purpose of preoperative chemotherapy is that it is capable of shrinking large primary tumors rendering many inoperable patients operable METHODS: 2 2 The doses of the drugs used were Cyclophosphamide - 600 mg/m IV infusion, Adriamycin - 50 mg/m IV infusion 2 and 5 uorouracil (FU) - 600 mg/m IV infusion. Clinical response was noted after 3 weeks of third cycle of NACT which was assessed according to RECIST criteria RESULTS: 78.1% of our patients responded to NACT (cCR + cPR) with pCR in 17.2% of patients. percentage of complete response was higher for patients in stage IIIA than for the patient in stage IIIB CONCLUSION: neo-adjuvant chemotherapy integrated into a multi-modality program is the standard management in patients with locally advanced breast carcinoma. The patients with pathological complete response and patients without axillary lymph node were associated with improved outcome after neo adjuvant chemo therapy