Lateral muscular myopathy associated with vitamin E deficiency in farmed barramundi, <i>Lates calcarifer</i> (Bloch)

Bowater, Rachel O; Burren, B

doi:10.1111/j.1365-2761.2007.00775.x

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Both muscular dystrophy and ceroid pigment deposits have been described among the symptoms of deficiency in vitamin E (Lovell et al 1984;Gatlin et al 1986;Frischknecht et al 1994;Bowater & Burren 2007), which being a fatsoluble vitamin it is deposited in the lipid fraction of tissues, including biomembranes, and plays an important role in protecting them from lipid peroxidation. In the present study, elevation of dietary vitamin E levels markedly reduced the incidence of these symptoms in sea bass, increasing the fish tissue content in several PUFA, which denotes the antioxidant and protective role of this vitamin, and improving survival.…”

Section: ó 2010 Blackwell Publishing Ltdmentioning

confidence: 99%

α-Tocopherol in weaning diets for European sea bass (Dicentrarchus labrax) improves survival and reduces tissue damage caused by excess dietary DHA contents

Betancor

Atalah

Caballero

et al. 2011

Aquaculture Nutrition

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The objective of the present study was to investigate the combined effect of several dietary contents of vitamin E and polyunsaturated fatty acids (PUFA), mainly docosahexaenoic acid (DHA), on growth, survival, biochemical composition and tissue morphology of sea bass along early development. A feeding experiment was conducted in sea bass larvae using five different diets with the same proximate composition and different ratios of DHA concentrated fish oil [10, 30 and 50 g kg−1 dry weight (DW)] and vitamin E (α‐tocopherol acetate) (1500 and 3000 mg kg−1 DW). DHA was readily deposited in fish tissues and associated with higher sea bass mortalities probably because of increased peroxidation risks. Besides, the elevation of dietary DHA contents up to 5% severely increased the incidence of muscular lesions and the presence of ceroid pigment within hepatocytes. However, elevation of dietary vitamin E levels markedly reduced the incidence of these symptoms in sea bass, increasing the tissue content in several PUFA and improving growth and stress resistance. Moreover, when sea bass was fed diets containing high vitamin E levels, fish showed a significant improvement in growth when dietary DHA was raised from 1% to 3%. Therefore, in sea bass larvae, a ratio of 30 g kg−1 DHA and 3000 mg kg−1 vitamin E seems to be adequate to achieve a good larval performance and to avoid muscular lesions.

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Section: ó 2010 Blackwell Publishing Ltdmentioning

confidence: 99%

α-Tocopherol in weaning diets for European sea bass (Dicentrarchus labrax) improves survival and reduces tissue damage caused by excess dietary DHA contents

Betancor

Atalah

Caballero

et al. 2011

Aquaculture Nutrition

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show abstract

“…; Lewis‐McCrea & Lall ). Among these skeletal alterations, one of the most frequently described in fish juveniles and adults is muscular dystrophy (Lovell, Miyazaki & Rabegnator ; Gatlin, Poe & Wilson ; Frischknecht, Wahli & Meier ; Bowater & Burren ). This muscular disorder has been associated with a vitamin E deficiency (Bowater & Burren ), suggesting the importance of this nutrient in the prevention of in vivo peroxidation.…”

Section: Introductionmentioning

confidence: 99%

“…In fish, some diseases have been related to free radical damage such as haemolysis (Kawatsu 1969), anaemia (Cowey et al 1984), jaundice (Sakai et al 1989), liver degeneration (Cowey et al 1984) or skeletal alterations (Watanabe et al 1989;Lewis-McCrea & Lall 2007). Among these skeletal alterations, one of the most frequently described in fish juveniles and adults is muscular dystrophy (Lovell, Miyazaki & Rabegnator 1984;Gatlin, Poe & Wilson 1986;Frischknecht, Wahli & Meier 1994;Bowater & Burren 2007). This muscular disorder has been associated with a vitamin E deficiency (Bowater & Burren 2007), suggesting the importance of this nutrient in the prevention of in vivo peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA

Betancor

Caballero

Benítez‐Santana

et al. 2012

Journal of Fish Diseases

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In previous studies, we observed dystrophic alterations in muscle of 48-day-old sea bass fed imbalanced docosahexaenoic acid (DHA) and vitamin E diets. To understand the whole pathological process associated with oxidative stress, a histological study was performed by feeding 14-day-old sea bass larvae with microdiets containing different ratios of DHA/vitamin E (1/150, 5/150 and 5/300) for a period of 21 days. Larvae fed diet 1/150 showed no lesions in contrast to larvae fed diets 5/150 and 5/300 where the highest incidence of muscle lesions and thiobarbituric acid reactive substances (TBARS) content was observed. Semithin sections revealed focal lesions consisting of degenerated fibres with hypercontracted myofilaments and extensive sarcoplasm vacuolization affecting both red and white muscle. Ultrathin sections of degenerating muscle fibres showed diffuse dilatation of sarcoplasmic reticulum, disorganized myofilaments and autophagic vacuoles containing myelin figures and dense bodies. Additionally, some macrophages were observed among injured fibres as numerous satellite cells. Results from the study agree with those obtained from previous work, proving the pathological potential of free radicals in sea bass larvae musculature. Moreover, high vitamin E inclusion could not completely protect cell membranes from free radicals action.

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“…Further study is necessary to elucidate this mechanism. Neurological symptoms that result from vitamin E deficiency include cerebellar ataxia, peripheral neuropathy, and myopathy [11][12][13][14][15][16][17][18][19][20]. Vitamin E plays a role in the stabilization of cell membranes due to its antioxidant activities [21].…”

Section: Discussionmentioning

confidence: 99%

Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy

Ueda

Suzuki

Rino

et al. 2009

Journal of the Neurological Sciences

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Lateral muscular myopathy associated with vitamin E deficiency in farmed barramundi, Lates calcarifer (Bloch)

Cited by 5 publications

References 16 publications

α-Tocopherol in weaning diets for European sea bass (Dicentrarchus labrax) improves survival and reduces tissue damage caused by excess dietary DHA contents

α-Tocopherol in weaning diets for European sea bass (Dicentrarchus labrax) improves survival and reduces tissue damage caused by excess dietary DHA contents

Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA

Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy

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