Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy

Ueda, Naohisa; Suzuki, Yume; Rino, Yasushi; Takahashi, Tatsuya; Imada, Toshio; Takanashi, Yoshinori; Kuroiwa, Yoshihiro

doi:10.1016/j.jns.2009.07.020

Cited by 29 publications

(27 citation statements)

References 22 publications

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“…For example, considering the numerous important functions of vitamin E in the body, a vitamin E deficiency can result in many different diseases, including spinocerebellar ataxia [5], ataxia [6], myoclonus-dystonia syndrome [7], and various other diseases [8][9][10]. Furthermore, vitamin E has also been shown to be effective against certain diseases, such as cardiovascular diseases [11], Alzheimer's disease [12], and nephropathy [13].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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Abstract. It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.

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Section: Introductionmentioning

confidence: 99%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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“…Low serum vitamin E levels were observed in 20.8 % of patients, and 10.4 % of patients suffered some neurological symptoms, i.e., peripheral neuropathy, limb or truncal ataxia. All patients with sensory polyneuropathy responded to treatment with oral vitamin E. An oral intake of 300 mg or more of vitamin E was necessary for normalization of the vitamin E levels [50]. In gastrectomized patients with neurologic symptoms and low serum total cholesterol levels that do not respond to treatment with vitamin B12, hypovitaminosis E should be suspected.…”

Section: Vitamin Ementioning

confidence: 99%

“…[25][26][27][28]32] No report No report Impaired night vision follicular hyperkeratosis [37] Total gastrectomy [37,38] D No [32][33][34] Possibly yes [35] No report No report No operative methods related to vitamin deficiency [43] E Yes [26][27][28][29][30][31][32] No report No report Peripheral neuropathy limb or truncal ataxia [39,40,50] Total gastrectomy without food passage through the duodenum [39,40] K No report No report No report No report No report…”

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer

2016

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Several authors have reported the relationship between gastric cancer risk and vitamins. However, there are few reports on fat-soluble vitamins after gastrectomy for gastric cancer. Fat malabsorption and suppression of food intake after gastrectomy for gastric cancer have been previously documented. Because of fat malabsorption and suppression of food intake, a potential deficiency in fat-soluble vitamins, such as vitamins A, D, E, and K, has been readily suggested. In about 20 % of patients, the serum vitamin E levels were decreased. Indeed, vitamin E deficiency is a common complication after gastrectomy. Continuous vitamin E deficiency could develop from neurological symptoms, i.e., peripheral neuropathy, limb or truncal ataxia. The total cholesterol level is associated with the vitamin E levels. However, the serum vitamin A levels were decreased in only 1.8 % of patients. In total gastrectomy cases, the serum vitamin A level may readily decrease. In contrast, 1,25(OH) vitamin D deficiency, which is the most active vitamin D metabolite, is rare. Additionally, vitamin K deficiency after gastrectomy has not been reported thus far. Evidence that serum fat-soluble vitamin levels may decrease after gastrectomy for gastric cancer has not been established yet. Future research must explore fat-soluble vitamin deficiency after gastrectomy.

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“…Idiopathic neurological disorders associated with symptoms resembling those of AVED should be further investigated at the clinical level and could be considered at least in certain cases for a symptomatic first-approach treatment with vitamin E. These may include some forms of inherited ataxias [102], and patients with tardive dyskinesia have been proposed as candidate population that may benefit of such a prophylactic treatment [96]. Some symptoms in rare neurodegenerative conditions such as familial dysautonomia seem to be positively affected by tocotrienol supplementation [103], and vitamin E supplementation is recommended in secondary neurological disturbance that may rise over the long-term as a consequence of vitamin E deficiency in gastrectomy patients [104].…”

Section: Neurodegenerative and Other Neurological Conditionsmentioning

confidence: 99%

Present trends in vitamin E research

2010

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Abstract.Nearly after one century of research and thousands of publications, the physiological function(s) of vitamin E remain unclear. Available evidence suggests a role in cell homeostasis that occurs through the modulation of specific signaling pathways and genes involved in proliferative, metabolic, inflammatory, and antioxidant pathways. Vitamin E presence in the human body is under close metabolic control so that only a-tocopherol and, to a lower extent, c-tocopherol are retained and delivered to tissues. Other vitamin E forms that are not retained in the body in significant amounts, exhibit responses in vitro that are different form those of a-tocopherol and may include tumor cell specific toxicity and apoptosis. These responses provide a therapeutic potential for these minor forms, either as such or metabolically modified, to produce bioactive metabolites. These cellular effects go beyond the properties of lipophilic antioxidant attributed to a-tocopherol particularly investigated for its alleged protective role in atherosclerosis or other oxidative stress conditions. Understanding signaling and gene expression effects of vitamin E could help assign a physiological role to this vitamin, which will be discussed in this review. Besides vitamin E signaling, attention will be given to tocotrienols as one of the emerging topics in vitamin E research and a critical re-examination of the most recent clinical trials will be provided together with the potential use of vitamin E in disease prevention and therapy.

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Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy

Cited by 29 publications

References 22 publications

Protective effect of vitamin E against acute kidney injury

Protective effect of vitamin E against acute kidney injury

Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer

Present trends in vitamin E research

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