Lateral inhibition in the auditory cortex: An EEG index of tinnitus?

Kadner, Alexander; Viirre, Erik; Wester, Derin; Walsh, Sally; Hestenes, J. D.; Vankov, Andrey; Pineda, Jaime A.

doi:10.1097/00001756-200203250-00016

Cited by 56 publications

(51 citation statements)

References 17 publications

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“…With respect to sample size, many neuroimaging studies draw conclusions about the underlying TI pathophysiology using group statistics with fewer than ten patients (e.g. Giraud et al, 1999;Kadner et al, 2002;Lockwood et al, 1998;Osaki et al, 2005). While such analyses might be adequate for characterising the common pathophysiology in that particular sample of patients, little can be inferred about the mechanisms underlying TI in the wider population.…”

Section: Discussionmentioning

confidence: 99%

“…Using MEG or EEG, an abnormally elevated response to external sounds (hyperexcitability) has also been shown to co-occur with TI (e.g. Hoke et al, 1989;Noreña et al, 1999;Kadner at al., 2002), but such hyperexcitability has been reported at frequencies unrelated to the dominant TI pitch and a number of studies have failed to replicate these results (Jacobson et al, 1991;Colding-Jorgensen et al, 1992;Attias et al, 1993), suggesting that this abnormal activity is unlikely to underpin the TI percept. The main focus of our review discusses the evidence for the three mechanisms, linking the animal models to current perspectives from human neuroimaging.…”

Section: The Neural Mechanisms Of Timentioning

confidence: 99%

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The mechanisms of tinnitus: Perspectives from human functional neuroimaging

2009

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In this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power. AbstractIn this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power.

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Section: Discussionmentioning

confidence: 99%

Section: The Neural Mechanisms Of Timentioning

confidence: 99%

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

2009

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“…Each older subject completed the Short Portable Mental Status Questionnaire and had two or fewer errors, signifying intact intellectual functioning (Pfeiffer, 1975). Several authors have hypothesized a link between N1-P2 amplitudes and tinnitus (Attias et al, 1993;Hoke et al, 1989;Kadner et al, 2002). Therefore, each subject completed a tinnitus questionnaire; only one older subject reported a significant history of tinnitus but did not report having tinnitus at the time of testing.…”

Section: Subjectsmentioning

confidence: 99%

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Harris

Mills

et al. 2008

Hearing Research

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“…Evidence from many studies suggested that most forms of tinnitus result from a loss of inhibition secondary to cochlear damage in central auditory structures. [37][38][39] This loss of inhibition disrupts the normal synchronized neural activity constrained by feed-forward inhibition to acoustic features of stimulus. In this model of tinnitus, it is supposed that related brain regions are abnormally underactive, and to compensate this under-activity, functions of neural networks are aberrantly increased when tinnitus is present.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Auditory Electrophysiological Responses Associated With Temporary Suppression of Tinnitus Induced by Low-Level Laser Therapy: A Before-After Case Series

et al. 2017

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IntroductionTinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus.1 This symptom is a debilitating condition that is widespread yet difficult to successfully diagnose and treat. The prevalence of chronic tinnitus in general population is estimated between 5%-15%. It causes serious psychosocial complications in 1% to 3%.2 For some subjects, tinnitus is disabling and restricts their work, sleep, and social activities. [3][4][5] This symptom has forced clinicians to attempt to establish protocols for accuracy of tinnitus diagnosis and treatment. 6 There are various modalities in the treatment of the chronic tinnitus (pharmacotherapy, physiotherapy, psychotherapy, surgery etc) targeted at diminishing tinnitus loudness and annoyance. The disappearance of tinnitus occurs very rarely among the subjects with chronic tinnitus and according to the literature they do not represent a statistically significant group. The new medical therapeutic method of low-level laser therapy (LLLT) uses low-energy-lasers or light-emitting diodes to stimulate or inhibit cellular function.7 Lowlevel laser (LLL) is widely used by specialists to treat non-healing ulcers, autoimmune diseases, acute and chronic musculoskeletal pains, chronic inflammations, hemangiomas and burns. It has been suggested to be Abstract Introduction: Tinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus. The treatment is difficult due to multiple etiologies and great psychological influence. The purpose of this study was to determine alterations in auditory physiological and electrophysiological responses associated with temporary suppression of tinnitus induced by low-level laser (LLL) irradiation. Methods: This study was conducted on 20 subjects with subjective tinnitus. All subjects signed the informed consent form and satisfied all the study eligibility criteria. Visual analog scale (VAS) for loudness, loudness matching of tinnitus (LMT), pitch matching of tinnitus (PMT), Persian-tinnitus questionnaire (P-TQ) and Persian-tinnitus handicap inventory (P-THI) were conducted pre-and post-low level laser therapy (LLLT) for all the subjects. Electrocochleography (ECochG) and distortion product otoacoustic emissions (DPOAEs) were recorded in 11 subjects. Continuous wave diode lasers, including red (630 nm) and infra-red (808 nm) were applied, and were both designed by the Canadian Optic and Laser (COL) Center. Twelve sessions of laser therapy were performed, 2 sessions per week for each subject. Total dose was 120 Joule/ ear/session. Results: LLL irradiation could cause a significant decrease in subjective tests scores consisting of VAS for loudness, PMT, P-TQ, P-THI, but did not result in a significant improvement of objective evaluating parameters except for compound action potential (CAP) amplitude. Conclusion: LLLT might be a subjectively effective treatment for short-term improvement of tinnitus. Defining a new protocol for optimizing LLLT paramete...

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Lateral inhibition in the auditory cortex: An EEG index of tinnitus?

Cited by 56 publications

References 17 publications

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Alterations in Auditory Electrophysiological Responses Associated With Temporary Suppression of Tinnitus Induced by Low-Level Laser Therapy: A Before-After Case Series

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