Latent Trajectories of Common Mental Health Disorder Risk Across 3 Decades of Adulthood in a Population-Based Cohort

Paksarian, Diana; Cui, Lihong; Angst, Jules; Ajdacic-Gross, Vladeta; Rössler, Wulf; Merikangas, Kathleen R.

doi:10.1001/jamapsychiatry.2016.1921

Cited by 25 publications

(23 citation statements)

References 54 publications

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“…Concerning age effects, dissociative effects of ketamine were negatively associated with age only in male participants. Early adulthood is a critical development stage that engenders vulnerability for a variety of mental disorders for women and men (Paksarian et al, 2016). Plenty of previously reported findings indicate that the effects of ketamine show variation across participants according to the basal status of associated circuits (Lahti et al, 2001; Corlett et al, 2006; Morgan et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

et al. 2019

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Ketamine is a drug that reduces depressive and elicits schizophrenia-like symptoms in humans. However, it is largely unexplored whether women and men differ with respect to ketamine-action and whether age contributes to drug-effects. In this study we assessed dissociative symptoms via the Clinician Administered Dissociative States Scale (CADSS) in a total of 69 healthy subjects aged between 18 and 30 years (early adulthood) after ketamine or placebo infusion. Dissociative symptoms were generally increased only in the ketamine group post-infusion. Specifically, within the ketamine group, men reported significantly more depersonalization and amnestic symptoms than women. Furthermore, with rising age only men were less affected overall with respect to dissociative symptoms. This suggests a sex-specific protective effect of higher age which may be due to delayed brain maturation in men compared to women. We conclude that it is crucial to include sex and age in studies of drug effects in general and of ketamine-action in specific to tailor more efficient psychiatric treatments. Clinical Trial Registration: EU Clinical Trials Register (EudraCT), trial number: 2010-023414-31.

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Section: Discussionmentioning

confidence: 99%

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

et al. 2019

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“…; Paksarian et al. ; Gadbois, Tyler, and Mor ). Thus, the greater the distance that an individual must travel to a nursing home with an SCU relative to a nursing home without an SCU, the less likely that individual is to be admitted to a facility with an SCU.…”

Section: Datamentioning

confidence: 97%

The Impact of Dementia Special Care Units on Quality of Care: An Instrumental Variables Analysis

Joyce

McGuire

Bartels

et al. 2018

Health Services Research

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“…Anxiety disorders are characterized by maladaptive responses to threats and are considered one of the largest group of disabling mental disorders in childhood and adolescence 1 . The estimated lifetime prevalence of anxiety disorders in studies with children or adolescents is about 15–20% 2 and is associated with a considerable degree of fluctuation in diagnostic status over time 3 , 4 . The persistence of anxiety symptoms and the chronicity of anxiety disorders are common, with recurrence of the same or different diagnoses across several time points throughout life 5 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Baumont

Hoffmann

Bortoluzzi

et al. 2021

Sci Rep

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Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.

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Latent Trajectories of Common Mental Health Disorder Risk Across 3 Decades of Adulthood in a Population-Based Cohort

Cited by 25 publications

References 54 publications

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

The Impact of Dementia Special Care Units on Quality of Care: An Instrumental Variables Analysis

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

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