Latent inhibition and facilitation of conditioned taste aversion in preweanling rats

Gaztañaga, Mirari; Aranda‐Fernández, P. Ezequiel; Diaz-Cenzano, Elena; Chotro, M. Gabriela

doi:10.1002/dev.21263

Cited by 7 publications

(11 citation statements)

References 30 publications

(60 reference statements)

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“…Examples of facilitation have been found with flavor stimuli, but again, only in restricted conditions. Pre-exposure has been found to facilitate subsequent olfactory (Hoffmann & Spear, 1989) and taste aversion conditioning (Chotro & Alonso, 2001;Gaztañaga, Aranda-Fernández, Díaz-Cenzano, & Chotro, 2015) in infant rats. This effect has usually been explained in terms of a deficiency in processing the stimulus, due to the immaturity of the sensory system of the infant rat; previous experience with the CS would allow a better processing of the stimulus.…”

Section: Discussionmentioning

confidence: 99%

Facilitation and retardation of flavor preference conditioning following prior exposure to the flavor conditioned stimulus

2018

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In two experiments, rats received pairings of an almond flavor (Experiments 1 and 2B) or a vanilla flavor (Experiment 2A) with sucrose. In each experiment, half of the rats received prior exposure to the flavor and half were exposed to water. Conditioned preference was then assessed through two-bottle, flavor versus water, choice tests. Latent inhibition (indicated by a weaker preference in pre-exposed subjects) was observed in the experiment using the vanilla flavor. However, facilitation (a stronger preference in pre-exposed subjects) instead of latent inhibition was evident with the almond flavor, both across acquisition trials and in the final choice test. These results indicate that, unlike most other paradigms of Pavlovian conditioning, conditioned stimulus pre-exposure in flavor preference learning may either facilitate or retard the acquisition (or the expression) of a conditioned flavor preference. We explore the proposal that the critical difference between the flavors lies in their hedonic values, with facilitation being more likely in a flavor that is initially disliked.

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Section: Discussionmentioning

confidence: 99%

Facilitation and retardation of flavor preference conditioning following prior exposure to the flavor conditioned stimulus

2018

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“…The particular procedure in each conditioning paradigm may involve specific structures in latent inhibition. Thus, in the CTA paradigm it has been showed in preweanling rats that the number of pre-exposures and the strength of the unconditioned stimulus (US) can promote latent inhibition, but these factors also can, however, facilitate taste aversion [38] . Therefore, it is possible that different factors of the particular procedure may promote the involvement of different neural mechanisms during each response.…”

Section: Discussionmentioning

confidence: 99%

Latent inhibition of conditioned taste aversion in rats with amygdaloid or hippocampal lesions

et al. 2016

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The amygdala and hippocampus play crucial roles in the latent inhibition of different conditioned responses, such as fear conditioned. Nevertheless, the involvement of these structures in the latent inhibition of conditioned taste aversion (CTA) is uncertain. In the present study, we explore the relevance of the amygdala and hippocampus in latent inhibition using a CTA paradigm. The effects of taste pre-exposures vs. non-pre-exposures on taste aversion conditioning were compared in Wistar rats with amygdaloid or hippocampal excitotoxic lesions. All pre-exposed animals consumed significantly more on the test day than did non-pre-exposed animals. Therefore, neither amygdaloid nor hippocampal lesions prevented the latent inhibition phenomenon. However, the expected taste neophobia was potentially affected by lesions to either the amygdala or hippocampus. These findings suggest that the amygdala and hippocampus seem to be necessary for taste neophobia but not for the acquisition of latent inhibition of CTA. The differential involvement of both structures in latent inhibition under different associative learning paradigms is briefly discussed.

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“…Moreover, the conditioning procedure used to study each aspect of associative learning could also reveal the involvement of specific structures in latent inhibition. For instance, in preweanling rats, the specific number of pre‐exposure trials and the intensity of the unconditioned stimulus can either induce the latent inhibition of CTA or facilitate conditioning (Gaztañaga et al, ). These differences in the procedure may promote the activation of different brain mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Latent inhibition of conditioned taste aversion in rats with excitotoxic dorsal hippocampal lesions

Molero‐Chamizo

Morón

2015

J of Neuroscience Research

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The hippocampus plays crucial roles for the acquisition of latent inhibition in different associative learning procedures, such as fear conditioning. However, the involvement of the hippocampus in the latent inhibition of conditioned taste aversion (CTA) is uncertain. Because different subregions of the hippocampus are associated with distinct functions, it is possible that specific regions of this structure are selectively involved in this learning. To explore the relationship between the dorsal hippocampal region and the latent inhibition of CTA, we analyzed the behavioral effects of excitotoxic lesions of the dorsal hippocampus vs. sham lesions in this paradigm. The results provide no evidence that the latent inhibition of CTA is compromised in rats with excitotoxic dorsal hippocampal lesions. The differential involvement of specific hippocampal regions in the latent inhibition of other associative learning paradigms is briefly discussed.

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Latent inhibition and facilitation of conditioned taste aversion in preweanling rats

Cited by 7 publications

References 30 publications

Facilitation and retardation of flavor preference conditioning following prior exposure to the flavor conditioned stimulus

Facilitation and retardation of flavor preference conditioning following prior exposure to the flavor conditioned stimulus

Latent inhibition of conditioned taste aversion in rats with amygdaloid or hippocampal lesions

Latent inhibition of conditioned taste aversion in rats with excitotoxic dorsal hippocampal lesions

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